McArdle disease with rhabdomyolysis induced by rosuvastatin: case report

Detalhes bibliográficos
Autor(a) principal: Lorenzoni,Paulo José
Data de Publicação: 2007
Outros Autores: Silvado,Carlos Eduardo, Scola,Rosana Herminia, Luvizotto,Mario, Werneck,Lineu César
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500020
Resumo: The rosuvastatin inducing rhabdomyolysis in McArdle disease (MD) has not been reported to date. A 35-years-old man had exercise intolerance, muscular fatigue and cramps during physical activity since infancy. He presented severe rhabdomyolysis episode with seizure and coma after use of rosuvastatin. The investigation showed increased serum creatinekinase levels and the forearm ischemic exercise did not increased venous lactate. The muscle biopsy showed subsarcolemmal and central acummulation of glycogen and absence of the myophosphorylase enzyme. The statin induced myopathy is discussed and the danger of its use in MD is emphasized.
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spelling McArdle disease with rhabdomyolysis induced by rosuvastatin: case reportMcArdle diseasetoxic myopathyrosuvastatinrhabdomyolysisstatin myopathyThe rosuvastatin inducing rhabdomyolysis in McArdle disease (MD) has not been reported to date. A 35-years-old man had exercise intolerance, muscular fatigue and cramps during physical activity since infancy. He presented severe rhabdomyolysis episode with seizure and coma after use of rosuvastatin. The investigation showed increased serum creatinekinase levels and the forearm ischemic exercise did not increased venous lactate. The muscle biopsy showed subsarcolemmal and central acummulation of glycogen and absence of the myophosphorylase enzyme. The statin induced myopathy is discussed and the danger of its use in MD is emphasized.Academia Brasileira de Neurologia - ABNEURO2007-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500020Arquivos de Neuro-Psiquiatria v.65 n.3b 2007reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2007000500020info:eu-repo/semantics/openAccessLorenzoni,Paulo JoséSilvado,Carlos EduardoScola,Rosana HerminiaLuvizotto,MarioWerneck,Lineu Césareng2008-04-11T00:00:00Zoai:scielo:S0004-282X2007000500020Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-04-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv McArdle disease with rhabdomyolysis induced by rosuvastatin: case report
title McArdle disease with rhabdomyolysis induced by rosuvastatin: case report
spellingShingle McArdle disease with rhabdomyolysis induced by rosuvastatin: case report
Lorenzoni,Paulo José
McArdle disease
toxic myopathy
rosuvastatin
rhabdomyolysis
statin myopathy
title_short McArdle disease with rhabdomyolysis induced by rosuvastatin: case report
title_full McArdle disease with rhabdomyolysis induced by rosuvastatin: case report
title_fullStr McArdle disease with rhabdomyolysis induced by rosuvastatin: case report
title_full_unstemmed McArdle disease with rhabdomyolysis induced by rosuvastatin: case report
title_sort McArdle disease with rhabdomyolysis induced by rosuvastatin: case report
author Lorenzoni,Paulo José
author_facet Lorenzoni,Paulo José
Silvado,Carlos Eduardo
Scola,Rosana Herminia
Luvizotto,Mario
Werneck,Lineu César
author_role author
author2 Silvado,Carlos Eduardo
Scola,Rosana Herminia
Luvizotto,Mario
Werneck,Lineu César
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lorenzoni,Paulo José
Silvado,Carlos Eduardo
Scola,Rosana Herminia
Luvizotto,Mario
Werneck,Lineu César
dc.subject.por.fl_str_mv McArdle disease
toxic myopathy
rosuvastatin
rhabdomyolysis
statin myopathy
topic McArdle disease
toxic myopathy
rosuvastatin
rhabdomyolysis
statin myopathy
description The rosuvastatin inducing rhabdomyolysis in McArdle disease (MD) has not been reported to date. A 35-years-old man had exercise intolerance, muscular fatigue and cramps during physical activity since infancy. He presented severe rhabdomyolysis episode with seizure and coma after use of rosuvastatin. The investigation showed increased serum creatinekinase levels and the forearm ischemic exercise did not increased venous lactate. The muscle biopsy showed subsarcolemmal and central acummulation of glycogen and absence of the myophosphorylase enzyme. The statin induced myopathy is discussed and the danger of its use in MD is emphasized.
publishDate 2007
dc.date.none.fl_str_mv 2007-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2007000500020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.65 n.3b 2007
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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