Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls
Autor(a) principal: | |
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Data de Publicação: | 1991 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200003 |
Resumo: | Quantitative measurements have indicated that heredity, cerebral damage, psycho-social aspects, ictal and inter-ictal phenomena and antiepileptic drugs may interfere in the cognitive dysfunction of epileptic patients. In the present study objective methods included immediate and late recall and recognition of pictures, Stroop test and auditory selection. Twenty patients with symptomatic localized epilepsy aged 17-52 years (27±10, mean ±sd) were compared to age and socially matched healthy controls. Patients were on therapeutic serum concentrations (25±12 m/mi) of phenobarbitone and had active epilepsy with 1.94 generalized tonic-clonic, 0.85 simple partial and 6.28 complex partial seizures monthly (means). Patients performed worse than controls in all 6 tests (p<0.05 to p<0.001), indicating a generalized cognitive deficit related to seizures and/or barbiturate therapy. We suggest further studies should be carried out in populations with uniform monotherapeutic regimens and epileptic syndromes in order to isolate factors related to the cognitive dysfunction of epileptic patients. |
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Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controlsQuantitative measurements have indicated that heredity, cerebral damage, psycho-social aspects, ictal and inter-ictal phenomena and antiepileptic drugs may interfere in the cognitive dysfunction of epileptic patients. In the present study objective methods included immediate and late recall and recognition of pictures, Stroop test and auditory selection. Twenty patients with symptomatic localized epilepsy aged 17-52 years (27±10, mean ±sd) were compared to age and socially matched healthy controls. Patients were on therapeutic serum concentrations (25±12 m/mi) of phenobarbitone and had active epilepsy with 1.94 generalized tonic-clonic, 0.85 simple partial and 6.28 complex partial seizures monthly (means). Patients performed worse than controls in all 6 tests (p<0.05 to p<0.001), indicating a generalized cognitive deficit related to seizures and/or barbiturate therapy. We suggest further studies should be carried out in populations with uniform monotherapeutic regimens and epileptic syndromes in order to isolate factors related to the cognitive dysfunction of epileptic patients.Academia Brasileira de Neurologia - ABNEURO1991-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200003Arquivos de Neuro-Psiquiatria v.49 n.2 1991reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1991000200003info:eu-repo/semantics/openAccessBigarella,Mônica M.Mäder,Maria J.Doro,Maribel P.Gorz,Ana M.Marcourakis,TâniaTsanaclis,LolitaBittencourt,Paulo R. M.eng2011-02-22T00:00:00Zoai:scielo:S0004-282X1991000200003Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2011-02-22T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls |
title |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls |
spellingShingle |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls Bigarella,Mônica M. |
title_short |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls |
title_full |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls |
title_fullStr |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls |
title_full_unstemmed |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls |
title_sort |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls |
author |
Bigarella,Mônica M. |
author_facet |
Bigarella,Mônica M. Mäder,Maria J. Doro,Maribel P. Gorz,Ana M. Marcourakis,Tânia Tsanaclis,Lolita Bittencourt,Paulo R. M. |
author_role |
author |
author2 |
Mäder,Maria J. Doro,Maribel P. Gorz,Ana M. Marcourakis,Tânia Tsanaclis,Lolita Bittencourt,Paulo R. M. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Bigarella,Mônica M. Mäder,Maria J. Doro,Maribel P. Gorz,Ana M. Marcourakis,Tânia Tsanaclis,Lolita Bittencourt,Paulo R. M. |
description |
Quantitative measurements have indicated that heredity, cerebral damage, psycho-social aspects, ictal and inter-ictal phenomena and antiepileptic drugs may interfere in the cognitive dysfunction of epileptic patients. In the present study objective methods included immediate and late recall and recognition of pictures, Stroop test and auditory selection. Twenty patients with symptomatic localized epilepsy aged 17-52 years (27±10, mean ±sd) were compared to age and socially matched healthy controls. Patients were on therapeutic serum concentrations (25±12 m/mi) of phenobarbitone and had active epilepsy with 1.94 generalized tonic-clonic, 0.85 simple partial and 6.28 complex partial seizures monthly (means). Patients performed worse than controls in all 6 tests (p<0.05 to p<0.001), indicating a generalized cognitive deficit related to seizures and/or barbiturate therapy. We suggest further studies should be carried out in populations with uniform monotherapeutic regimens and epileptic syndromes in order to isolate factors related to the cognitive dysfunction of epileptic patients. |
publishDate |
1991 |
dc.date.none.fl_str_mv |
1991-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X1991000200003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.49 n.2 1991 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212747450515456 |