Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300183 |
Resumo: | ABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients. Objective To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients. Methods Thirty-three adult patients with a clinical and molecular diagnosis of HSP were evaluated before and after Btx-A injections. Results Mean age was 41.7 ± 13.6 years and there were 18 women. Most patients had a pure phenotype and SPG4 was the most frequent genotype. The Btx-A injections resulted in a decrease in spasticity at the adductor muscles, and no other motor measure was significantly modified. In contrast, fatigue scores were significantly reduced after Btx-A injections. Conclusion Btx-A injections resulted in no significant functional motor improvement for HSP, but fatigue improved after treatment. |
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Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestationsbotulinum toxinspastic paraplegiahereditarymuscle spasticityABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients. Objective To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients. Methods Thirty-three adult patients with a clinical and molecular diagnosis of HSP were evaluated before and after Btx-A injections. Results Mean age was 41.7 ± 13.6 years and there were 18 women. Most patients had a pure phenotype and SPG4 was the most frequent genotype. The Btx-A injections resulted in a decrease in spasticity at the adductor muscles, and no other motor measure was significantly modified. In contrast, fatigue scores were significantly reduced after Btx-A injections. Conclusion Btx-A injections resulted in no significant functional motor improvement for HSP, but fatigue improved after treatment.Academia Brasileira de Neurologia - ABNEURO2018-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300183Arquivos de Neuro-Psiquiatria v.76 n.3 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180013info:eu-repo/semantics/openAccessServelhere,Katiane R.Faber,IngridMartinez,AlbertoNickel,RenatoMoro,AdrianaGerminiani,Francisco M. B.Moscovich,MarianaBlume,Tatiane R.Munhoz,Renato P.Teive,Hélio A. G.França Jr,Marcondes C.eng2018-06-26T00:00:00Zoai:scielo:S0004-282X2018000300183Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-06-26T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
title |
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
spellingShingle |
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations Servelhere,Katiane R. botulinum toxin spastic paraplegia hereditary muscle spasticity |
title_short |
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
title_full |
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
title_fullStr |
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
title_full_unstemmed |
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
title_sort |
Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations |
author |
Servelhere,Katiane R. |
author_facet |
Servelhere,Katiane R. Faber,Ingrid Martinez,Alberto Nickel,Renato Moro,Adriana Germiniani,Francisco M. B. Moscovich,Mariana Blume,Tatiane R. Munhoz,Renato P. Teive,Hélio A. G. França Jr,Marcondes C. |
author_role |
author |
author2 |
Faber,Ingrid Martinez,Alberto Nickel,Renato Moro,Adriana Germiniani,Francisco M. B. Moscovich,Mariana Blume,Tatiane R. Munhoz,Renato P. Teive,Hélio A. G. França Jr,Marcondes C. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Servelhere,Katiane R. Faber,Ingrid Martinez,Alberto Nickel,Renato Moro,Adriana Germiniani,Francisco M. B. Moscovich,Mariana Blume,Tatiane R. Munhoz,Renato P. Teive,Hélio A. G. França Jr,Marcondes C. |
dc.subject.por.fl_str_mv |
botulinum toxin spastic paraplegia hereditary muscle spasticity |
topic |
botulinum toxin spastic paraplegia hereditary muscle spasticity |
description |
ABSTRACT Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients. Objective To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients. Methods Thirty-three adult patients with a clinical and molecular diagnosis of HSP were evaluated before and after Btx-A injections. Results Mean age was 41.7 ± 13.6 years and there were 18 women. Most patients had a pure phenotype and SPG4 was the most frequent genotype. The Btx-A injections resulted in a decrease in spasticity at the adductor muscles, and no other motor measure was significantly modified. In contrast, fatigue scores were significantly reduced after Btx-A injections. Conclusion Btx-A injections resulted in no significant functional motor improvement for HSP, but fatigue improved after treatment. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300183 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000300183 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20180013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.76 n.3 2018 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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