Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample

Detalhes bibliográficos
Autor(a) principal: Cordeiro,Quirino
Data de Publicação: 2014
Outros Autores: Vallada,Homero
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582
Resumo: Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes.
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spelling Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sampleassociation studydopaminegeneticspsychosisSchizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes.Academia Brasileira de Neurologia - ABNEURO2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582Arquivos de Neuro-Psiquiatria v.72 n.8 2014reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20140100info:eu-repo/semantics/openAccessCordeiro,QuirinoVallada,Homeroeng2014-08-01T00:00:00Zoai:scielo:S0004-282X2014000800582Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2014-08-01T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
spellingShingle Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
Cordeiro,Quirino
association study
dopamine
genetics
psychosis
title_short Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title_full Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title_fullStr Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title_full_unstemmed Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title_sort Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
author Cordeiro,Quirino
author_facet Cordeiro,Quirino
Vallada,Homero
author_role author
author2 Vallada,Homero
author2_role author
dc.contributor.author.fl_str_mv Cordeiro,Quirino
Vallada,Homero
dc.subject.por.fl_str_mv association study
dopamine
genetics
psychosis
topic association study
dopamine
genetics
psychosis
description Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20140100
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.72 n.8 2014
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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