Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200004 |
Resumo: | Epidemiological studies have demonstrated that the genetic component is an important risk factor for the development of schizophrenia. The genes that codify the different compounds of the dopaminergic system have created interest for molecular investigations in patients with schizophrenia because the antipsychotic drugs, especially those of first generation, act on this cerebral system. Thus the aim of the present study was to investigate the possible association between the -141 Ins/Del (rs1799732) polymorphism of the dopamine receptor type 2 (DRD2) and schizophrenia. The distribution of the alleles and genotypes of the studied polymorphism was investigated in a sample of 229 patients and 733 controls. There were statistical differences in the allelic (χ2=9.78; p=0.001) and genotypic genotypic (χ2=12.74; p=0.001) distributions between patients and controls. Thus the -141C Ins/Del polymorphism of the DRD2 gene (allele Ins) was associated to the SCZ phenotype in the investigated sample. |
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Arquivos de neuro-psiquiatria (Online) |
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Association between the DRD2-141C Insertion/Deletion polymorphism and schizophreniadopaminegeneticsD2receptorschizophreniaEpidemiological studies have demonstrated that the genetic component is an important risk factor for the development of schizophrenia. The genes that codify the different compounds of the dopaminergic system have created interest for molecular investigations in patients with schizophrenia because the antipsychotic drugs, especially those of first generation, act on this cerebral system. Thus the aim of the present study was to investigate the possible association between the -141 Ins/Del (rs1799732) polymorphism of the dopamine receptor type 2 (DRD2) and schizophrenia. The distribution of the alleles and genotypes of the studied polymorphism was investigated in a sample of 229 patients and 733 controls. There were statistical differences in the allelic (χ2=9.78; p=0.001) and genotypic genotypic (χ2=12.74; p=0.001) distributions between patients and controls. Thus the -141C Ins/Del polymorphism of the DRD2 gene (allele Ins) was associated to the SCZ phenotype in the investigated sample.Academia Brasileira de Neurologia - ABNEURO2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200004Arquivos de Neuro-Psiquiatria v.67 n.2a 2009reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2009000200004info:eu-repo/semantics/openAccessCordeiro,QuirinoSiqueira-Roberto,JacquelineZung,StevinVallada,Homeroeng2009-06-05T00:00:00Zoai:scielo:S0004-282X2009000200004Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2009-06-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia |
title |
Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia |
spellingShingle |
Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia Cordeiro,Quirino dopamine genetics D2 receptor schizophrenia |
title_short |
Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia |
title_full |
Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia |
title_fullStr |
Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia |
title_full_unstemmed |
Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia |
title_sort |
Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia |
author |
Cordeiro,Quirino |
author_facet |
Cordeiro,Quirino Siqueira-Roberto,Jacqueline Zung,Stevin Vallada,Homero |
author_role |
author |
author2 |
Siqueira-Roberto,Jacqueline Zung,Stevin Vallada,Homero |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Cordeiro,Quirino Siqueira-Roberto,Jacqueline Zung,Stevin Vallada,Homero |
dc.subject.por.fl_str_mv |
dopamine genetics D2 receptor schizophrenia |
topic |
dopamine genetics D2 receptor schizophrenia |
description |
Epidemiological studies have demonstrated that the genetic component is an important risk factor for the development of schizophrenia. The genes that codify the different compounds of the dopaminergic system have created interest for molecular investigations in patients with schizophrenia because the antipsychotic drugs, especially those of first generation, act on this cerebral system. Thus the aim of the present study was to investigate the possible association between the -141 Ins/Del (rs1799732) polymorphism of the dopamine receptor type 2 (DRD2) and schizophrenia. The distribution of the alleles and genotypes of the studied polymorphism was investigated in a sample of 229 patients and 733 controls. There were statistical differences in the allelic (χ2=9.78; p=0.001) and genotypic genotypic (χ2=12.74; p=0.001) distributions between patients and controls. Thus the -141C Ins/Del polymorphism of the DRD2 gene (allele Ins) was associated to the SCZ phenotype in the investigated sample. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2009000200004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.67 n.2a 2009 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212765530062848 |