Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)

Detalhes bibliográficos
Autor(a) principal: Puga,Fernanda
Data de Publicação: 2005
Outros Autores: Veiga,Heloisa, Cagy,Maurício, McDowell,Kaleb, Piedade,Roberto, Ribeiro,Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000200008
Resumo: Benzodiazepines have been used in the pharmacological treatment of anxiety for over four decades. However, very few studies have combined bromazepam and event-related potentials (ERP). The present study aimed at investigating the modulatory effects of this drug on brain dynamics. Specifically, the effects of bromazepam (3mg) on the P300 component of the ERP were tested in a double-blind experiment. The sample, consisting of 15 healthy subjects (7 male and 8 female), was submitted to a visual discrimination task, which employed the "oddball" paradigm. Electrophysiological (P300) and behavioral measures (stroop, digit span, and reaction time) were analyzed across three experimental conditions: placebo 1, placebo 2, and bromazepam. Results suggest that the effects of bromazepam (3mg) on cognitive processes are not apparent. In spite of what seems irrefutable in current literature, bromazepam did not produce evident effects on the behavioral and electrophysiological variables analyzed.
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spelling Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)bromazepamevent-related potentialP300Benzodiazepines have been used in the pharmacological treatment of anxiety for over four decades. However, very few studies have combined bromazepam and event-related potentials (ERP). The present study aimed at investigating the modulatory effects of this drug on brain dynamics. Specifically, the effects of bromazepam (3mg) on the P300 component of the ERP were tested in a double-blind experiment. The sample, consisting of 15 healthy subjects (7 male and 8 female), was submitted to a visual discrimination task, which employed the "oddball" paradigm. Electrophysiological (P300) and behavioral measures (stroop, digit span, and reaction time) were analyzed across three experimental conditions: placebo 1, placebo 2, and bromazepam. Results suggest that the effects of bromazepam (3mg) on cognitive processes are not apparent. In spite of what seems irrefutable in current literature, bromazepam did not produce evident effects on the behavioral and electrophysiological variables analyzed.Academia Brasileira de Neurologia - ABNEURO2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000200008Arquivos de Neuro-Psiquiatria v.63 n.2a 2005reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2005000200008info:eu-repo/semantics/openAccessPuga,FernandaVeiga,HeloisaCagy,MaurícioMcDowell,KalebPiedade,RobertoRibeiro,Pedroeng2005-07-05T00:00:00Zoai:scielo:S0004-282X2005000200008Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2005-07-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)
title Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)
spellingShingle Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)
Puga,Fernanda
bromazepam
event-related potential
P300
title_short Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)
title_full Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)
title_fullStr Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)
title_full_unstemmed Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)
title_sort Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300)
author Puga,Fernanda
author_facet Puga,Fernanda
Veiga,Heloisa
Cagy,Maurício
McDowell,Kaleb
Piedade,Roberto
Ribeiro,Pedro
author_role author
author2 Veiga,Heloisa
Cagy,Maurício
McDowell,Kaleb
Piedade,Roberto
Ribeiro,Pedro
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Puga,Fernanda
Veiga,Heloisa
Cagy,Maurício
McDowell,Kaleb
Piedade,Roberto
Ribeiro,Pedro
dc.subject.por.fl_str_mv bromazepam
event-related potential
P300
topic bromazepam
event-related potential
P300
description Benzodiazepines have been used in the pharmacological treatment of anxiety for over four decades. However, very few studies have combined bromazepam and event-related potentials (ERP). The present study aimed at investigating the modulatory effects of this drug on brain dynamics. Specifically, the effects of bromazepam (3mg) on the P300 component of the ERP were tested in a double-blind experiment. The sample, consisting of 15 healthy subjects (7 male and 8 female), was submitted to a visual discrimination task, which employed the "oddball" paradigm. Electrophysiological (P300) and behavioral measures (stroop, digit span, and reaction time) were analyzed across three experimental conditions: placebo 1, placebo 2, and bromazepam. Results suggest that the effects of bromazepam (3mg) on cognitive processes are not apparent. In spite of what seems irrefutable in current literature, bromazepam did not produce evident effects on the behavioral and electrophysiological variables analyzed.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000200008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000200008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2005000200008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.63 n.2a 2005
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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