Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice

Detalhes bibliográficos
Autor(a) principal: Milhomem,Anália Cirqueira
Data de Publicação: 2018
Outros Autores: Souza,Amanda Juliana Soaris de, Silva,Hidelberto Matos, Vinaud,Marina Clare, Oliveira,Milton Adriano Pelli de, Machado,Juliana Reis, Lino Júnior,Ruy de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500339
Resumo: ABSTRACT Neurocysticercosis (NCC) is one of the parasitic infections that most affects the central nervous system. The knowledge regarding its immunopathogenesis and pathophysiology needs broadening. Taenia crassiceps cysticerci are used as the NCC experimental model. The aim of this work was to describe the general pathological processes and the in situ cytokine profile in C57BL/6 mice inoculated intracranially with viable T. crassiceps cysticerci. The histopathology analysis showed cysticerci in the extraparenchymal and intraventricular region, mononuclear inflammatory infiltration surrounding the parasite, microgliosis and meningitis. The analysis of the in situ immune profiles showed a predominance of the Th2 response. The IL-4 and IL-10 dosages were significantly increased in the infected group. The decrease in the INF-gamma dosage reflects the immunomodulation from the cysticerci. In conclusion, a T. crassiceps NCC infection in C57BL/6 mice triggers an inflammatory response, a predominance of Th2 type in situ profile, with mononuclear inflammatory cell infiltration, meningitis and microgliosis.
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spelling Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 miceneurocysticercosisneglected diseasesTaeniaABSTRACT Neurocysticercosis (NCC) is one of the parasitic infections that most affects the central nervous system. The knowledge regarding its immunopathogenesis and pathophysiology needs broadening. Taenia crassiceps cysticerci are used as the NCC experimental model. The aim of this work was to describe the general pathological processes and the in situ cytokine profile in C57BL/6 mice inoculated intracranially with viable T. crassiceps cysticerci. The histopathology analysis showed cysticerci in the extraparenchymal and intraventricular region, mononuclear inflammatory infiltration surrounding the parasite, microgliosis and meningitis. The analysis of the in situ immune profiles showed a predominance of the Th2 response. The IL-4 and IL-10 dosages were significantly increased in the infected group. The decrease in the INF-gamma dosage reflects the immunomodulation from the cysticerci. In conclusion, a T. crassiceps NCC infection in C57BL/6 mice triggers an inflammatory response, a predominance of Th2 type in situ profile, with mononuclear inflammatory cell infiltration, meningitis and microgliosis.Academia Brasileira de Neurologia - ABNEURO2018-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500339Arquivos de Neuro-Psiquiatria v.76 n.5 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20180032info:eu-repo/semantics/openAccessMilhomem,Anália CirqueiraSouza,Amanda Juliana Soaris deSilva,Hidelberto MatosVinaud,Marina ClareOliveira,Milton Adriano Pelli deMachado,Juliana ReisLino Júnior,Ruy de Souzaeng2018-05-25T00:00:00Zoai:scielo:S0004-282X2018000500339Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-05-25T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice
title Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice
spellingShingle Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice
Milhomem,Anália Cirqueira
neurocysticercosis
neglected diseases
Taenia
title_short Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice
title_full Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice
title_fullStr Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice
title_full_unstemmed Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice
title_sort Histopathologic aspects of experimental cysticercosis and in situ cytokines profile in C57BL/6 mice
author Milhomem,Anália Cirqueira
author_facet Milhomem,Anália Cirqueira
Souza,Amanda Juliana Soaris de
Silva,Hidelberto Matos
Vinaud,Marina Clare
Oliveira,Milton Adriano Pelli de
Machado,Juliana Reis
Lino Júnior,Ruy de Souza
author_role author
author2 Souza,Amanda Juliana Soaris de
Silva,Hidelberto Matos
Vinaud,Marina Clare
Oliveira,Milton Adriano Pelli de
Machado,Juliana Reis
Lino Júnior,Ruy de Souza
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Milhomem,Anália Cirqueira
Souza,Amanda Juliana Soaris de
Silva,Hidelberto Matos
Vinaud,Marina Clare
Oliveira,Milton Adriano Pelli de
Machado,Juliana Reis
Lino Júnior,Ruy de Souza
dc.subject.por.fl_str_mv neurocysticercosis
neglected diseases
Taenia
topic neurocysticercosis
neglected diseases
Taenia
description ABSTRACT Neurocysticercosis (NCC) is one of the parasitic infections that most affects the central nervous system. The knowledge regarding its immunopathogenesis and pathophysiology needs broadening. Taenia crassiceps cysticerci are used as the NCC experimental model. The aim of this work was to describe the general pathological processes and the in situ cytokine profile in C57BL/6 mice inoculated intracranially with viable T. crassiceps cysticerci. The histopathology analysis showed cysticerci in the extraparenchymal and intraventricular region, mononuclear inflammatory infiltration surrounding the parasite, microgliosis and meningitis. The analysis of the in situ immune profiles showed a predominance of the Th2 response. The IL-4 and IL-10 dosages were significantly increased in the infected group. The decrease in the INF-gamma dosage reflects the immunomodulation from the cysticerci. In conclusion, a T. crassiceps NCC infection in C57BL/6 mice triggers an inflammatory response, a predominance of Th2 type in situ profile, with mononuclear inflammatory cell infiltration, meningitis and microgliosis.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500339
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000500339
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282x20180032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.76 n.5 2018
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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