The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis

Detalhes bibliográficos
Autor(a) principal: Puccioni-Sohler,Marzia
Data de Publicação: 1995
Outros Autores: Kitze,Bernd, Felgenhauer,Klaus, Graef,Iris T., Lange,Peter, Novis,Sergio, Reiber,Hansotto, Vaz,Beatriz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1995000500008
Resumo: Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/ tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono- and polyspecific immune responses is discussed for these chronic neurological diseases.
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spelling The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosisHTLV-IHAM/TSPcerebrospinal fluidantibody indexCerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/ tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono- and polyspecific immune responses is discussed for these chronic neurological diseases.Academia Brasileira de Neurologia - ABNEURO1995-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1995000500008Arquivos de Neuro-Psiquiatria v.53 n.4 1995reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1995000500008info:eu-repo/semantics/openAccessPuccioni-Sohler,MarziaKitze,BerndFelgenhauer,KlausGraef,Iris T.Lange,PeterNovis,SergioReiber,HansottoVaz,Beatrizeng2010-12-08T00:00:00Zoai:scielo:S0004-282X1995000500008Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-12-08T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis
title The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis
spellingShingle The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis
Puccioni-Sohler,Marzia
HTLV-I
HAM/TSP
cerebrospinal fluid
antibody index
title_short The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis
title_full The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis
title_fullStr The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis
title_full_unstemmed The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis
title_sort The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis
author Puccioni-Sohler,Marzia
author_facet Puccioni-Sohler,Marzia
Kitze,Bernd
Felgenhauer,Klaus
Graef,Iris T.
Lange,Peter
Novis,Sergio
Reiber,Hansotto
Vaz,Beatriz
author_role author
author2 Kitze,Bernd
Felgenhauer,Klaus
Graef,Iris T.
Lange,Peter
Novis,Sergio
Reiber,Hansotto
Vaz,Beatriz
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Puccioni-Sohler,Marzia
Kitze,Bernd
Felgenhauer,Klaus
Graef,Iris T.
Lange,Peter
Novis,Sergio
Reiber,Hansotto
Vaz,Beatriz
dc.subject.por.fl_str_mv HTLV-I
HAM/TSP
cerebrospinal fluid
antibody index
topic HTLV-I
HAM/TSP
cerebrospinal fluid
antibody index
description Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/ tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono- and polyspecific immune responses is discussed for these chronic neurological diseases.
publishDate 1995
dc.date.none.fl_str_mv 1995-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1995000500008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1995000500008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1995000500008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.53 n.4 1995
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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