Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55678 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Freitas, Nicole LardiniGomes, Yago Côrtes PinheiroSouza, Flávia dos SantosTorres, Rafael CarvalhoEchevarria-Lima, JulianaLeite, Ana Claudia Celestino BezerraLima, Marco Antonio Sales DantasAraújo, Abelardo Queiroz CamposSilva, Marcus Tulius TeixeiraEspíndola, Otávio de Melo2022-11-17T17:13:14Z2022-11-17T17:13:14Z2022FREITAS, Nicole Lardini et al. Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development. Viruses, v. 14, n. 10, p. 1-18, 2022.1999-4915https://www.arca.fiocruz.br/handle/icict/5567810.3390/v14102146engMDPILessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Developmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Puericultura e Pediatria Martagão Gesteira. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease that leads to motor impairment due to a chronic inflammatory process in the central nervous system (CNS). However, the HAM/TSP pathogenesis is not completely clear, and biomarkers to define the disease prognosis are still necessary. Thus, we aimed to identify biomarkers for HAM/TSP and potential mechanisms involved in disease development. To that end, the concentrations of VILIP-1, BDNF, VEGF, β-NGF, TGF-β1, fractalkine/CX3CL1, IL-6, IL-18, and TNF-α, and the soluble forms of TREM-1, TREM-2, and RAGE, were assessed using a multiplex bead-based immunoassay in paired cerebrospinal fluid (CSF) and serum samples from HAM/TSP patients (n = 20), asymptomatic HTLV-1 carriers (AC) (n = 13), and HTLV-1-seronegative individuals (n = 9), with the results analyzed according to the speed of HAM/TSP progression. HAM/TSP patients had elevated fractalkine in the serum but not in the CSF, particularly those with low neuroinflammatory activity (CSF/serum ratio of neopterin <1 and of CXCL10 < 2). HAM/TSP patients with normal CSF levels of neurofilament light chain (NfL) showed elevated β-NGF in serum, and serum BDNF levels were increased in HTLV-1-infected individuals, particularly in HTLV-1 AC. Both HTLV-1 AC and HAM/TSP patients had lower TGF-β1 levels in CSF compared to uninfected individuals, and HAM/TSP patients with active CNS inflammation showed higher CSF levels of IL-18, which correlated with markers of inflammation, neuronal death, and blood-brain-barrier permeability. Although none of the factors evaluated were associated with the speed of HAM/TSP progression, reduced TGF-β1 levels in CSF suggest that suppressive responses to control subclinical and/or active neurodegeneration are impaired, while increased CSF IL-18 indicates the involvement of inflammasome-mediated mechanisms in HAM/TSP development.HAM/TSPHTLV-1IL-18BiomarkersCerebrospinal fluidInflammasomeNeurodegenerationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55678/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLessons_Nicole_Freitas_etal_INI_2022.pdfLessons_Nicole_Freitas_etal_INI_2022.pdfapplication/pdf4040252https://www.arca.fiocruz.br/bitstream/icict/55678/2/Lessons_Nicole_Freitas_etal_INI_2022.pdf57edbc8bcf7de1e223ce92224883e5c7MD52icict/556782022-11-17 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| dc.title.en_US.fl_str_mv |
Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development |
| title |
Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development |
| spellingShingle |
Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development Freitas, Nicole Lardini HAM/TSP HTLV-1 IL-18 Biomarkers Cerebrospinal fluid Inflammasome Neurodegeneration |
| title_short |
Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development |
| title_full |
Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development |
| title_fullStr |
Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development |
| title_full_unstemmed |
Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development |
| title_sort |
Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development |
| author |
Freitas, Nicole Lardini |
| author_facet |
Freitas, Nicole Lardini Gomes, Yago Côrtes Pinheiro Souza, Flávia dos Santos Torres, Rafael Carvalho Echevarria-Lima, Juliana Leite, Ana Claudia Celestino Bezerra Lima, Marco Antonio Sales Dantas Araújo, Abelardo Queiroz Campos Silva, Marcus Tulius Teixeira Espíndola, Otávio de Melo |
| author_role |
author |
| author2 |
Gomes, Yago Côrtes Pinheiro Souza, Flávia dos Santos Torres, Rafael Carvalho Echevarria-Lima, Juliana Leite, Ana Claudia Celestino Bezerra Lima, Marco Antonio Sales Dantas Araújo, Abelardo Queiroz Campos Silva, Marcus Tulius Teixeira Espíndola, Otávio de Melo |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Freitas, Nicole Lardini Gomes, Yago Côrtes Pinheiro Souza, Flávia dos Santos Torres, Rafael Carvalho Echevarria-Lima, Juliana Leite, Ana Claudia Celestino Bezerra Lima, Marco Antonio Sales Dantas Araújo, Abelardo Queiroz Campos Silva, Marcus Tulius Teixeira Espíndola, Otávio de Melo |
| dc.subject.en.en_US.fl_str_mv |
HAM/TSP HTLV-1 IL-18 Biomarkers Cerebrospinal fluid Inflammasome Neurodegeneration |
| topic |
HAM/TSP HTLV-1 IL-18 Biomarkers Cerebrospinal fluid Inflammasome Neurodegeneration |
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Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2022 |
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2022-11-17T17:13:14Z |
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2022-11-17T17:13:14Z |
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2022 |
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FREITAS, Nicole Lardini et al. Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development. Viruses, v. 14, n. 10, p. 1-18, 2022. |
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https://www.arca.fiocruz.br/handle/icict/55678 |
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1999-4915 |
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10.3390/v14102146 |
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FREITAS, Nicole Lardini et al. Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development. Viruses, v. 14, n. 10, p. 1-18, 2022. 1999-4915 10.3390/v14102146 |
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