Activation of left intraparietal sulcus using a fMRI conceptual praxis paradigm

• Autor(a) principal: MOLL,JORGE
• Data de Publicação: 1998
• Outros Autores: OLIVEIRA-SOUZA,RICARDO DE, SOUZA-LIMA,FABIANA DE, ANDREIUOLO,PEDRO ANGELO
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000500017
• topic: conceptual apraxia; intraparietal sulcus; cerebral asymmetry; functional magnetic resonance imaging

The present paper reports the results of a fMRI subtraction study of the pattern of cortical activation induced by an ideational praxis paradigm in six normal right-handed subjects. The control task consisted of a sequence of complex meaningless hand movements. A complete study was done for each hand in each subject. The left intraparietal sulcus was the only structure activated in all subjects regardless of the hand used in the task. These findings, albeit preliminary, suggest that the organization of actions involving the mediation of tools and utensils are strongly lateralized to the left hemisphere and that damage to the dominant intraparietal sulcus may be critical for the development of the clinical syndrome of conceptual apraxia.