Alcohol consumption and sudden unexpected death in epilepsy: experimental approach
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000600008 |
Resumo: | Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence. |
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Alcohol consumption and sudden unexpected death in epilepsy: experimental approachepilepsyalcoholheartseizureSUDEPUsing the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence.Academia Brasileira de Neurologia - ABNEURO2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000600008Arquivos de Neuro-Psiquiatria v.67 n.4 2009reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2009000600008info:eu-repo/semantics/openAccessScorzaI,Carla A.Cysneiros,Roberta M.Arida,Ricardo M.Terra,Vera C.Machado,Hélio R.Almeida,Antonio-Carlos G. deCavalheiro,Esper A.Scorza,Fulvio A.eng2009-12-16T00:00:00Zoai:scielo:S0004-282X2009000600008Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2009-12-16T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
title |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
spellingShingle |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach ScorzaI,Carla A. epilepsy alcohol heart seizure SUDEP |
title_short |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
title_full |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
title_fullStr |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
title_full_unstemmed |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
title_sort |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
author |
ScorzaI,Carla A. |
author_facet |
ScorzaI,Carla A. Cysneiros,Roberta M. Arida,Ricardo M. Terra,Vera C. Machado,Hélio R. Almeida,Antonio-Carlos G. de Cavalheiro,Esper A. Scorza,Fulvio A. |
author_role |
author |
author2 |
Cysneiros,Roberta M. Arida,Ricardo M. Terra,Vera C. Machado,Hélio R. Almeida,Antonio-Carlos G. de Cavalheiro,Esper A. Scorza,Fulvio A. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
ScorzaI,Carla A. Cysneiros,Roberta M. Arida,Ricardo M. Terra,Vera C. Machado,Hélio R. Almeida,Antonio-Carlos G. de Cavalheiro,Esper A. Scorza,Fulvio A. |
dc.subject.por.fl_str_mv |
epilepsy alcohol heart seizure SUDEP |
topic |
epilepsy alcohol heart seizure SUDEP |
description |
Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000600008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000600008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2009000600008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.67 n.4 2009 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212767453151232 |