Alcohol consumption and sudden unexpected death in epilepsy: experimental approach
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S0004-282X2009000600008 http://repositorio.unifesp.br/handle/11600/5429 |
Resumo: | Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence. |
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Alcohol consumption and sudden unexpected death in epilepsy: experimental approachConsumo de álcool e morte súbita em epilepsia: uma abordagem experimentalepilepsyalcoholheartseizureSUDEPepilepsiaálcoolcoraçãocrise epilépticaSUDEPUsing the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence.Utilizando o modelo de epilepsia induzido pela pilocarpina, investigamos os efeitos do consumo de álcool sobre a frequência de crises epilépticas em animais com epilepsia, como também uma possível associação entre a ingestão de álcool e ocorrência de morte súbita e inesperada nas epilepsias (SUDEP). Os animais foram randomicamente divididos em dois grupos: (A) ratos com epilepsia e (B) ratos com epilepsia que receberam uma dose diária de etanol (350 mg kg-1, i.p.) por 30 dias consecutivos. A frequência basal de crises epilépticas observadas nos grupos A e B durante os primeiros 30 dias foram de 3,4±1,5 e 3,2±1,9 crises por semana/animal, respectivamente. No grupo B, ocorreu aumento significativo na frequência de crises (11,6±5,3) durante as duas primeiras semanas de administração do álcool e de forma interessante, um animal morreu subitamente após uma crise generalizada tônico-clonica durante esse período. Concluímos em nossa abordagem experimental que existe uma possível associação entre o consumo de álcool e a ocorrência de SUDEP.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUniversidade Presbiteriana Mackenzie Centro de Ciências Biológicas e da SaúdeUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de FisiologiaUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Neurologia, Psiquiatria e PsicologiaUniversidade Federal de São João Del Rei Departamento de Engenharia BiomédicaUNIFESP, EPM, Depto. de FisiologiaSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Universidade Presbiteriana Mackenzie Centro de Ciências Biológicas e da SaúdeUniversidade de São Paulo (USP)Universidade Federal de São João Del Rei Departamento de Engenharia BiomédicaScorza, Carla Alessandra [UNIFESP]Cysneiros, Roberta Monterazzo [UNIFESP]Arida, Ricardo Mario [UNIFESP]Terra, Vera CristinaMachado, Helio RubensAlmeida, Antonio-Carlos G. deCavalheiro, Esper Abrão [UNIFESP]Scorza, Fulvio Alexandre [UNIFESP]2015-06-14T13:41:21Z2015-06-14T13:41:21Z2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1003-1006application/pdfhttp://dx.doi.org/10.1590/S0004-282X2009000600008Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 67, n. 4, p. 1003-1006, 2009.10.1590/S0004-282X2009000600008S0004-282X2009000600008.pdf0004-282XS0004-282X2009000600008http://repositorio.unifesp.br/handle/11600/5429WOS:000272736500008engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T17:45:19Zoai:repositorio.unifesp.br/:11600/5429Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T17:45:19Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach Consumo de álcool e morte súbita em epilepsia: uma abordagem experimental |
| title |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
| spellingShingle |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach Scorza, Carla Alessandra [UNIFESP] epilepsy alcohol heart seizure SUDEP epilepsia álcool coração crise epiléptica SUDEP |
| title_short |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
| title_full |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
| title_fullStr |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
| title_full_unstemmed |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
| title_sort |
Alcohol consumption and sudden unexpected death in epilepsy: experimental approach |
| author |
Scorza, Carla Alessandra [UNIFESP] |
| author_facet |
Scorza, Carla Alessandra [UNIFESP] Cysneiros, Roberta Monterazzo [UNIFESP] Arida, Ricardo Mario [UNIFESP] Terra, Vera Cristina Machado, Helio Rubens Almeida, Antonio-Carlos G. de Cavalheiro, Esper Abrão [UNIFESP] Scorza, Fulvio Alexandre [UNIFESP] |
| author_role |
author |
| author2 |
Cysneiros, Roberta Monterazzo [UNIFESP] Arida, Ricardo Mario [UNIFESP] Terra, Vera Cristina Machado, Helio Rubens Almeida, Antonio-Carlos G. de Cavalheiro, Esper Abrão [UNIFESP] Scorza, Fulvio Alexandre [UNIFESP] |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Presbiteriana Mackenzie Centro de Ciências Biológicas e da Saúde Universidade de São Paulo (USP) Universidade Federal de São João Del Rei Departamento de Engenharia Biomédica |
| dc.contributor.author.fl_str_mv |
Scorza, Carla Alessandra [UNIFESP] Cysneiros, Roberta Monterazzo [UNIFESP] Arida, Ricardo Mario [UNIFESP] Terra, Vera Cristina Machado, Helio Rubens Almeida, Antonio-Carlos G. de Cavalheiro, Esper Abrão [UNIFESP] Scorza, Fulvio Alexandre [UNIFESP] |
| dc.subject.por.fl_str_mv |
epilepsy alcohol heart seizure SUDEP epilepsia álcool coração crise epiléptica SUDEP |
| topic |
epilepsy alcohol heart seizure SUDEP epilepsia álcool coração crise epiléptica SUDEP |
| description |
Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg-1, i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4±1.5 and 3.2±1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6±5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009-12-01 2015-06-14T13:41:21Z 2015-06-14T13:41:21Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-282X2009000600008 Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 67, n. 4, p. 1003-1006, 2009. 10.1590/S0004-282X2009000600008 S0004-282X2009000600008.pdf 0004-282X S0004-282X2009000600008 http://repositorio.unifesp.br/handle/11600/5429 WOS:000272736500008 |
| url |
http://dx.doi.org/10.1590/S0004-282X2009000600008 http://repositorio.unifesp.br/handle/11600/5429 |
| identifier_str_mv |
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 67, n. 4, p. 1003-1006, 2009. 10.1590/S0004-282X2009000600008 S0004-282X2009000600008.pdf 0004-282X S0004-282X2009000600008 WOS:000272736500008 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria |
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info:eu-repo/semantics/openAccess |
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openAccess |
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1003-1006 application/pdf |
| dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
| publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268401664655360 |