Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods

Detalhes bibliográficos
Autor(a) principal: PUCCIONI-SOHLER,MARZIA
Data de Publicação: 1999
Outros Autores: PASSER,FABIOLA, OLIVEIRA,CRISTIANE, BRANDÃO,CARLOS OTÁVIO, PAPAIZ-ALVARENGA,REGINA
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600005
Resumo: The demonstration of intrathecal IgG synthesis has been used as an important laboratory parameter to support the diagnosis of multiple sclerosis(MS). The Committee for European Concerted Action for Multiple Sclerosis has recommended a protocol for the assessment of intrathecal IgG synthesis. We applied this methodology to determine the cerebrospinal (CSF) profile of 128 Brazilian patients with MS. We detected hypercytosis lower than 35 cells/mm3 in 97%, protein lower than 80mg/dl in 99%, normal blood-CSF barrier function in 76%, increased IgG local production around 53% and oligoclonal IgG bands by isoelectric focusing in 85% of the definite MS patients. The diagnostic accuracy of the quantitative analysis was lower than the qualitative. The detection of oligoclonal bands was especially important in the cases of normal quantitative assays of IgG. In addition, we found a lower frequency of inflammatory reaction in CSF in our MS cases, in comparison to some European studies.
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spelling Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methodsmultiple sclerosiscerebrospinal fluidoligoclonal bandsisoelectric focusingThe demonstration of intrathecal IgG synthesis has been used as an important laboratory parameter to support the diagnosis of multiple sclerosis(MS). The Committee for European Concerted Action for Multiple Sclerosis has recommended a protocol for the assessment of intrathecal IgG synthesis. We applied this methodology to determine the cerebrospinal (CSF) profile of 128 Brazilian patients with MS. We detected hypercytosis lower than 35 cells/mm3 in 97%, protein lower than 80mg/dl in 99%, normal blood-CSF barrier function in 76%, increased IgG local production around 53% and oligoclonal IgG bands by isoelectric focusing in 85% of the definite MS patients. The diagnostic accuracy of the quantitative analysis was lower than the qualitative. The detection of oligoclonal bands was especially important in the cases of normal quantitative assays of IgG. In addition, we found a lower frequency of inflammatory reaction in CSF in our MS cases, in comparison to some European studies.Academia Brasileira de Neurologia - ABNEURO1999-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600005Arquivos de Neuro-Psiquiatria v.57 n.4 1999reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1999000600005info:eu-repo/semantics/openAccessPUCCIONI-SOHLER,MARZIAPASSER,FABIOLAOLIVEIRA,CRISTIANEBRANDÃO,CARLOS OTÁVIOPAPAIZ-ALVARENGA,REGINAeng2000-04-03T00:00:00Zoai:scielo:S0004-282X1999000600005Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2000-04-03T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods
title Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods
spellingShingle Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods
PUCCIONI-SOHLER,MARZIA
multiple sclerosis
cerebrospinal fluid
oligoclonal bands
isoelectric focusing
title_short Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods
title_full Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods
title_fullStr Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods
title_full_unstemmed Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods
title_sort Multiple sclerosis in Brazil: analysis of cerebrospinal fluid by standard methods
author PUCCIONI-SOHLER,MARZIA
author_facet PUCCIONI-SOHLER,MARZIA
PASSER,FABIOLA
OLIVEIRA,CRISTIANE
BRANDÃO,CARLOS OTÁVIO
PAPAIZ-ALVARENGA,REGINA
author_role author
author2 PASSER,FABIOLA
OLIVEIRA,CRISTIANE
BRANDÃO,CARLOS OTÁVIO
PAPAIZ-ALVARENGA,REGINA
author2_role author
author
author
author
dc.contributor.author.fl_str_mv PUCCIONI-SOHLER,MARZIA
PASSER,FABIOLA
OLIVEIRA,CRISTIANE
BRANDÃO,CARLOS OTÁVIO
PAPAIZ-ALVARENGA,REGINA
dc.subject.por.fl_str_mv multiple sclerosis
cerebrospinal fluid
oligoclonal bands
isoelectric focusing
topic multiple sclerosis
cerebrospinal fluid
oligoclonal bands
isoelectric focusing
description The demonstration of intrathecal IgG synthesis has been used as an important laboratory parameter to support the diagnosis of multiple sclerosis(MS). The Committee for European Concerted Action for Multiple Sclerosis has recommended a protocol for the assessment of intrathecal IgG synthesis. We applied this methodology to determine the cerebrospinal (CSF) profile of 128 Brazilian patients with MS. We detected hypercytosis lower than 35 cells/mm3 in 97%, protein lower than 80mg/dl in 99%, normal blood-CSF barrier function in 76%, increased IgG local production around 53% and oligoclonal IgG bands by isoelectric focusing in 85% of the definite MS patients. The diagnostic accuracy of the quantitative analysis was lower than the qualitative. The detection of oligoclonal bands was especially important in the cases of normal quantitative assays of IgG. In addition, we found a lower frequency of inflammatory reaction in CSF in our MS cases, in comparison to some European studies.
publishDate 1999
dc.date.none.fl_str_mv 1999-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000600005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1999000600005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.57 n.4 1999
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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