Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo

Detalhes bibliográficos
Autor(a) principal: Gama,Paulo Diniz da
Data de Publicação: 2009
Outros Autores: Machado,Luís dos Ramos, Livramento,José Antonio, Gomes,Hélio Rodrigues, Adoni,Tarso, Lino,Angelina Maria Martins, Marchiori,Paulo Eurípedes, Morales,Rogério de Rizo, Lana-Peixoto,Marco Aurélio, Callegaro,Dagoberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000600011
Resumo: The frequency of oligoclonal bands (OCB) restricted to the cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) varies widely in different populations. The objective of this study was to determine the frequency of these OCB in a group of MS patients in the city of São Paulo. Techniques used to detect OCB consisted of isoelectric focusing followed by immunoblotting. Oligoclonal bands were found in 49 (54.4%) out of 90 patients with clinically definite MS; in (31.2%) of the 16 patients with clinically isolated syndrome; in 7 (17.9%) of 39 patients with inflammatory disorders of the central nervous system (IDCNS), and in none of the individuals with no neurological condition (control group). The specificity of the method was 100% when compared to the control group and 82.1% when compared to the IDCNS group. These results suggest that the frequency of CSF OCB is much lower in Brazilian MS patients from São Paulo city than that reported in MS series from Caucasian populations.
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spelling Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulomultiple sclerosiscerebrospinal fluidoligoclonal bandsBrazilian populationThe frequency of oligoclonal bands (OCB) restricted to the cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) varies widely in different populations. The objective of this study was to determine the frequency of these OCB in a group of MS patients in the city of São Paulo. Techniques used to detect OCB consisted of isoelectric focusing followed by immunoblotting. Oligoclonal bands were found in 49 (54.4%) out of 90 patients with clinically definite MS; in (31.2%) of the 16 patients with clinically isolated syndrome; in 7 (17.9%) of 39 patients with inflammatory disorders of the central nervous system (IDCNS), and in none of the individuals with no neurological condition (control group). The specificity of the method was 100% when compared to the control group and 82.1% when compared to the IDCNS group. These results suggest that the frequency of CSF OCB is much lower in Brazilian MS patients from São Paulo city than that reported in MS series from Caucasian populations.Academia Brasileira de Neurologia - ABNEURO2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000600011Arquivos de Neuro-Psiquiatria v.67 n.4 2009reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2009000600011info:eu-repo/semantics/openAccessGama,Paulo Diniz daMachado,Luís dos RamosLivramento,José AntonioGomes,Hélio RodriguesAdoni,TarsoLino,Angelina Maria MartinsMarchiori,Paulo EurípedesMorales,Rogério de RizoLana-Peixoto,Marco AurélioCallegaro,Dagobertoeng2009-12-16T00:00:00Zoai:scielo:S0004-282X2009000600011Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2009-12-16T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo
title Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo
spellingShingle Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo
Gama,Paulo Diniz da
multiple sclerosis
cerebrospinal fluid
oligoclonal bands
Brazilian population
title_short Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo
title_full Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo
title_fullStr Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo
title_full_unstemmed Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo
title_sort Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo
author Gama,Paulo Diniz da
author_facet Gama,Paulo Diniz da
Machado,Luís dos Ramos
Livramento,José Antonio
Gomes,Hélio Rodrigues
Adoni,Tarso
Lino,Angelina Maria Martins
Marchiori,Paulo Eurípedes
Morales,Rogério de Rizo
Lana-Peixoto,Marco Aurélio
Callegaro,Dagoberto
author_role author
author2 Machado,Luís dos Ramos
Livramento,José Antonio
Gomes,Hélio Rodrigues
Adoni,Tarso
Lino,Angelina Maria Martins
Marchiori,Paulo Eurípedes
Morales,Rogério de Rizo
Lana-Peixoto,Marco Aurélio
Callegaro,Dagoberto
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gama,Paulo Diniz da
Machado,Luís dos Ramos
Livramento,José Antonio
Gomes,Hélio Rodrigues
Adoni,Tarso
Lino,Angelina Maria Martins
Marchiori,Paulo Eurípedes
Morales,Rogério de Rizo
Lana-Peixoto,Marco Aurélio
Callegaro,Dagoberto
dc.subject.por.fl_str_mv multiple sclerosis
cerebrospinal fluid
oligoclonal bands
Brazilian population
topic multiple sclerosis
cerebrospinal fluid
oligoclonal bands
Brazilian population
description The frequency of oligoclonal bands (OCB) restricted to the cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) varies widely in different populations. The objective of this study was to determine the frequency of these OCB in a group of MS patients in the city of São Paulo. Techniques used to detect OCB consisted of isoelectric focusing followed by immunoblotting. Oligoclonal bands were found in 49 (54.4%) out of 90 patients with clinically definite MS; in (31.2%) of the 16 patients with clinically isolated syndrome; in 7 (17.9%) of 39 patients with inflammatory disorders of the central nervous system (IDCNS), and in none of the individuals with no neurological condition (control group). The specificity of the method was 100% when compared to the control group and 82.1% when compared to the IDCNS group. These results suggest that the frequency of CSF OCB is much lower in Brazilian MS patients from São Paulo city than that reported in MS series from Caucasian populations.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000600011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000600011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2009000600011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.67 n.4 2009
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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