Expression of a cell death marker (clusterin) in muscle target fibers

Detalhes bibliográficos
Autor(a) principal: Oliveira,Acary Souza Bulle
Data de Publicação: 1993
Outros Autores: Corbo,Massimo, Duigou,Greg, Gabbai,Alberto Alain, Hays,Arthur P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300014
Resumo: We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.
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spelling Expression of a cell death marker (clusterin) in muscle target fibersskeletal muscletargetclusterinWe report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.Academia Brasileira de Neurologia - ABNEURO1993-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300014Arquivos de Neuro-Psiquiatria v.51 n.3 1993reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1993000300014info:eu-repo/semantics/openAccessOliveira,Acary Souza BulleCorbo,MassimoDuigou,GregGabbai,Alberto AlainHays,Arthur P.eng2011-01-19T00:00:00Zoai:scielo:S0004-282X1993000300014Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2011-01-19T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Expression of a cell death marker (clusterin) in muscle target fibers
title Expression of a cell death marker (clusterin) in muscle target fibers
spellingShingle Expression of a cell death marker (clusterin) in muscle target fibers
Oliveira,Acary Souza Bulle
skeletal muscle
target
clusterin
title_short Expression of a cell death marker (clusterin) in muscle target fibers
title_full Expression of a cell death marker (clusterin) in muscle target fibers
title_fullStr Expression of a cell death marker (clusterin) in muscle target fibers
title_full_unstemmed Expression of a cell death marker (clusterin) in muscle target fibers
title_sort Expression of a cell death marker (clusterin) in muscle target fibers
author Oliveira,Acary Souza Bulle
author_facet Oliveira,Acary Souza Bulle
Corbo,Massimo
Duigou,Greg
Gabbai,Alberto Alain
Hays,Arthur P.
author_role author
author2 Corbo,Massimo
Duigou,Greg
Gabbai,Alberto Alain
Hays,Arthur P.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Acary Souza Bulle
Corbo,Massimo
Duigou,Greg
Gabbai,Alberto Alain
Hays,Arthur P.
dc.subject.por.fl_str_mv skeletal muscle
target
clusterin
topic skeletal muscle
target
clusterin
description We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.
publishDate 1993
dc.date.none.fl_str_mv 1993-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X1993000300014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.51 n.3 1993
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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