Expression of a cell death marker (clusterin) in muscle target fibers
Autor(a) principal: | |
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Data de Publicação: | 1993 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0004-282X1993000300014 http://repositorio.unifesp.br/handle/11600/325 |
Resumo: | We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation. |
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Repositório Institucional da UNIFESP |
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Expression of a cell death marker (clusterin) in muscle target fibersExpressão de marcador de morte celular programada (apoptosis) em fibras musculares com «target»skeletal muscletargetclusterinmúsculo esqueléticofibras com «target»clusterinaWe report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.Descrevemos, pela primeira vez, a expressão de imunorreatividade para clusterina em músculo esquelético. Clusterina, proteína relacionada ao processo de morte celular programada (apoptosis), encontrou-se especificamente muito aumentada em fibras musculares com «target» (FT). Todas as FT encontradas em 50 biópsias musculares de pacientes com diferentes doenças neuromusculares apresentaram alta concentração de clusterina no centro das FT. Clusterina não esteve semelhantemente aumentada em fibras com «targetóide» ou com «core». A alta expressão de clusterina em «targets» indica que FT podem ser o início de apoptosis e que há íntima relação entre FT e desnervação aguda.Escola Paulista de Medicina Department of NeurologyColumbia University College of Physicians and Surgeons Department of NeurosurgeryUNIFESP, EPM, Department of NeurologySciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Columbia University College of Physicians and Surgeons Department of NeurosurgeryOliveira, Acary Souza Bulle [UNIFESP]Corbo, MassimoDuigou, GregGabbai, Alberto Alain [UNIFESP]Hays, Arthur P.2015-06-14T13:24:24Z2015-06-14T13:24:24Z1993-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion371-376application/pdfhttp://dx.doi.org/10.1590/S0004-282X1993000300014Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 51, n. 3, p. 371-376, 1993.10.1590/S0004-282X1993000300014S0004-282X1993000300014.pdf0004-282XS0004-282X1993000300014http://repositorio.unifesp.br/handle/11600/325engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T16:19:40Zoai:repositorio.unifesp.br/:11600/325Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T16:19:40Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Expression of a cell death marker (clusterin) in muscle target fibers Expressão de marcador de morte celular programada (apoptosis) em fibras musculares com «target» |
title |
Expression of a cell death marker (clusterin) in muscle target fibers |
spellingShingle |
Expression of a cell death marker (clusterin) in muscle target fibers Oliveira, Acary Souza Bulle [UNIFESP] skeletal muscle target clusterin músculo esquelético fibras com «target» clusterina |
title_short |
Expression of a cell death marker (clusterin) in muscle target fibers |
title_full |
Expression of a cell death marker (clusterin) in muscle target fibers |
title_fullStr |
Expression of a cell death marker (clusterin) in muscle target fibers |
title_full_unstemmed |
Expression of a cell death marker (clusterin) in muscle target fibers |
title_sort |
Expression of a cell death marker (clusterin) in muscle target fibers |
author |
Oliveira, Acary Souza Bulle [UNIFESP] |
author_facet |
Oliveira, Acary Souza Bulle [UNIFESP] Corbo, Massimo Duigou, Greg Gabbai, Alberto Alain [UNIFESP] Hays, Arthur P. |
author_role |
author |
author2 |
Corbo, Massimo Duigou, Greg Gabbai, Alberto Alain [UNIFESP] Hays, Arthur P. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Columbia University College of Physicians and Surgeons Department of Neurosurgery |
dc.contributor.author.fl_str_mv |
Oliveira, Acary Souza Bulle [UNIFESP] Corbo, Massimo Duigou, Greg Gabbai, Alberto Alain [UNIFESP] Hays, Arthur P. |
dc.subject.por.fl_str_mv |
skeletal muscle target clusterin músculo esquelético fibras com «target» clusterina |
topic |
skeletal muscle target clusterin músculo esquelético fibras com «target» clusterina |
description |
We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation. |
publishDate |
1993 |
dc.date.none.fl_str_mv |
1993-09-01 2015-06-14T13:24:24Z 2015-06-14T13:24:24Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-282X1993000300014 Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 51, n. 3, p. 371-376, 1993. 10.1590/S0004-282X1993000300014 S0004-282X1993000300014.pdf 0004-282X S0004-282X1993000300014 http://repositorio.unifesp.br/handle/11600/325 |
url |
http://dx.doi.org/10.1590/S0004-282X1993000300014 http://repositorio.unifesp.br/handle/11600/325 |
identifier_str_mv |
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 51, n. 3, p. 371-376, 1993. 10.1590/S0004-282X1993000300014 S0004-282X1993000300014.pdf 0004-282X S0004-282X1993000300014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
371-376 application/pdf |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1818191278391689216 |