Expression of a cell death marker (clusterin) in muscle target fibers

Detalhes bibliográficos
Autor(a) principal: Oliveira, Acary Souza Bulle [UNIFESP]
Data de Publicação: 1993
Outros Autores: Corbo, Massimo, Duigou, Greg, Gabbai, Alberto Alain [UNIFESP], Hays, Arthur P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-282X1993000300014
http://repositorio.unifesp.br/handle/11600/325
Resumo: We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.
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spelling Expression of a cell death marker (clusterin) in muscle target fibersExpressão de marcador de morte celular programada (apoptosis) em fibras musculares com «target»skeletal muscletargetclusterinmúsculo esqueléticofibras com «target»clusterinaWe report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.Descrevemos, pela primeira vez, a expressão de imunorreatividade para clusterina em músculo esquelético. Clusterina, proteína relacionada ao processo de morte celular programada (apoptosis), encontrou-se especificamente muito aumentada em fibras musculares com «target» (FT). Todas as FT encontradas em 50 biópsias musculares de pacientes com diferentes doenças neuromusculares apresentaram alta concentração de clusterina no centro das FT. Clusterina não esteve semelhantemente aumentada em fibras com «targetóide» ou com «core». A alta expressão de clusterina em «targets» indica que FT podem ser o início de apoptosis e que há íntima relação entre FT e desnervação aguda.Escola Paulista de Medicina Department of NeurologyColumbia University College of Physicians and Surgeons Department of NeurosurgeryUNIFESP, EPM, Department of NeurologySciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Columbia University College of Physicians and Surgeons Department of NeurosurgeryOliveira, Acary Souza Bulle [UNIFESP]Corbo, MassimoDuigou, GregGabbai, Alberto Alain [UNIFESP]Hays, Arthur P.2015-06-14T13:24:24Z2015-06-14T13:24:24Z1993-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion371-376application/pdfhttp://dx.doi.org/10.1590/S0004-282X1993000300014Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 51, n. 3, p. 371-376, 1993.10.1590/S0004-282X1993000300014S0004-282X1993000300014.pdf0004-282XS0004-282X1993000300014http://repositorio.unifesp.br/handle/11600/325engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T16:19:40Zoai:repositorio.unifesp.br/:11600/325Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T16:19:40Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Expression of a cell death marker (clusterin) in muscle target fibers
Expressão de marcador de morte celular programada (apoptosis) em fibras musculares com «target»
title Expression of a cell death marker (clusterin) in muscle target fibers
spellingShingle Expression of a cell death marker (clusterin) in muscle target fibers
Oliveira, Acary Souza Bulle [UNIFESP]
skeletal muscle
target
clusterin
músculo esquelético
fibras com «target»
clusterina
title_short Expression of a cell death marker (clusterin) in muscle target fibers
title_full Expression of a cell death marker (clusterin) in muscle target fibers
title_fullStr Expression of a cell death marker (clusterin) in muscle target fibers
title_full_unstemmed Expression of a cell death marker (clusterin) in muscle target fibers
title_sort Expression of a cell death marker (clusterin) in muscle target fibers
author Oliveira, Acary Souza Bulle [UNIFESP]
author_facet Oliveira, Acary Souza Bulle [UNIFESP]
Corbo, Massimo
Duigou, Greg
Gabbai, Alberto Alain [UNIFESP]
Hays, Arthur P.
author_role author
author2 Corbo, Massimo
Duigou, Greg
Gabbai, Alberto Alain [UNIFESP]
Hays, Arthur P.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Columbia University College of Physicians and Surgeons Department of Neurosurgery
dc.contributor.author.fl_str_mv Oliveira, Acary Souza Bulle [UNIFESP]
Corbo, Massimo
Duigou, Greg
Gabbai, Alberto Alain [UNIFESP]
Hays, Arthur P.
dc.subject.por.fl_str_mv skeletal muscle
target
clusterin
músculo esquelético
fibras com «target»
clusterina
topic skeletal muscle
target
clusterin
músculo esquelético
fibras com «target»
clusterina
description We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.
publishDate 1993
dc.date.none.fl_str_mv 1993-09-01
2015-06-14T13:24:24Z
2015-06-14T13:24:24Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-282X1993000300014
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 51, n. 3, p. 371-376, 1993.
10.1590/S0004-282X1993000300014
S0004-282X1993000300014.pdf
0004-282X
S0004-282X1993000300014
http://repositorio.unifesp.br/handle/11600/325
url http://dx.doi.org/10.1590/S0004-282X1993000300014
http://repositorio.unifesp.br/handle/11600/325
identifier_str_mv Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 51, n. 3, p. 371-376, 1993.
10.1590/S0004-282X1993000300014
S0004-282X1993000300014.pdf
0004-282X
S0004-282X1993000300014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 371-376
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268293478875136

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