Is there a relationship between narcolepsy, multiple sclerosis and HLA-DQB1*06:02?

• Autor(a) principal: Lorenzoni,Paulo José
• Data de Publicação: 2017
• Outros Autores: Werneck,Lineu Cesar, Crippa,Ana Christina de Souza, Zanatta,Alessandra, Kay,Cláudia S. Kamoi, Silvado,Carlos Eduardo S., Scola,Rosana Herminia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000600345
• topic: narcolepsy; multiple sclerosis; human leukocyte antigen; polysomnography

ABSTRACT We studied multiple sclerosis (MS) patients with the HLA-DQB1*06:02 allele and compared them with MS patients who did not carry the HLA-DQB1*06:02 allele. We analyzed clinical and neurophysiological criteria for narcolepsy in six MS patients with HLA-DQB1*06:02, compared with 12 MS patients who were HLA-DQB1*06:02 non-carriers. Only two patients with HLA-DQB1*06:02 allele scored higher than 10 on the Epworth Sleepiness Scale. Polysomnography recording parameters and the multiple sleep latency test showed an absence of narcolepsy in the study group. Our study suggested no significant correlation between narcolepsy, MS and HLA-DQB1*06:02. The HLA-DQB1*06:02 allele alone was not sufficient to cause MS patients to develop narcolepsy.