HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first cases

Detalhes bibliográficos
Autor(a) principal: Vidal,José E.
Data de Publicação: 2007
Outros Autores: Clifford,David, Ferreira,Cláudio Meilman, Oliveira,Augusto C. Penalva de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500024
Resumo: We describe two Brazilian patients with HIV-associated neuromuscular weakness syndrome (HANWS), a unique clinical toxic syndrome that was recently reported in developed countries. Both patients were women, used stavudine and had hyperlactatemia, one of them with lactic acidosis. Eletrophysiological studies were consistent with axonal neuropathy. After discontinuation of antiretroviral therapy the patients had significant improvement in neurologic manifestations, and normalization of lactate levels. To our knowledge, this is the first report of HANWS in developing countries. Growing use of antiretroviral therapy in this setting, particularly stavudine, make it likely that similar cases will be observed.
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spelling HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first casesneuromuscular diseasesperipheral neuropathiesantiretroviral agentshuman immunodeficiency virusWe describe two Brazilian patients with HIV-associated neuromuscular weakness syndrome (HANWS), a unique clinical toxic syndrome that was recently reported in developed countries. Both patients were women, used stavudine and had hyperlactatemia, one of them with lactic acidosis. Eletrophysiological studies were consistent with axonal neuropathy. After discontinuation of antiretroviral therapy the patients had significant improvement in neurologic manifestations, and normalization of lactate levels. To our knowledge, this is the first report of HANWS in developing countries. Growing use of antiretroviral therapy in this setting, particularly stavudine, make it likely that similar cases will be observed.Academia Brasileira de Neurologia - ABNEURO2007-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500024Arquivos de Neuro-Psiquiatria v.65 n.3b 2007reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2007000500024info:eu-repo/semantics/openAccessVidal,José E.Clifford,DavidFerreira,Cláudio MeilmanOliveira,Augusto C. Penalva deeng2008-04-11T00:00:00Zoai:scielo:S0004-282X2007000500024Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-04-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first cases
title HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first cases
spellingShingle HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first cases
Vidal,José E.
neuromuscular diseases
peripheral neuropathies
antiretroviral agents
human immunodeficiency virus
title_short HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first cases
title_full HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first cases
title_fullStr HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first cases
title_full_unstemmed HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first cases
title_sort HIV-associated neuromuscular weakness syndrome in Brazil: report of the two first cases
author Vidal,José E.
author_facet Vidal,José E.
Clifford,David
Ferreira,Cláudio Meilman
Oliveira,Augusto C. Penalva de
author_role author
author2 Clifford,David
Ferreira,Cláudio Meilman
Oliveira,Augusto C. Penalva de
author2_role author
author
author
dc.contributor.author.fl_str_mv Vidal,José E.
Clifford,David
Ferreira,Cláudio Meilman
Oliveira,Augusto C. Penalva de
dc.subject.por.fl_str_mv neuromuscular diseases
peripheral neuropathies
antiretroviral agents
human immunodeficiency virus
topic neuromuscular diseases
peripheral neuropathies
antiretroviral agents
human immunodeficiency virus
description We describe two Brazilian patients with HIV-associated neuromuscular weakness syndrome (HANWS), a unique clinical toxic syndrome that was recently reported in developed countries. Both patients were women, used stavudine and had hyperlactatemia, one of them with lactic acidosis. Eletrophysiological studies were consistent with axonal neuropathy. After discontinuation of antiretroviral therapy the patients had significant improvement in neurologic manifestations, and normalization of lactate levels. To our knowledge, this is the first report of HANWS in developing countries. Growing use of antiretroviral therapy in this setting, particularly stavudine, make it likely that similar cases will be observed.
publishDate 2007
dc.date.none.fl_str_mv 2007-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2007000500024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.65 n.3b 2007
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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