Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis

Detalhes bibliográficos
Autor(a) principal: Souza,Paulo Victor Sgobbi de
Data de Publicação: 2016
Outros Autores: Pinto,Wladimir Bocca Vieira de Rezende, Rezende Filho,Flávio Moura, Oliveira,Acary Souza Bulle
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000849
Resumo: ABSTRACT Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.
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spelling Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosismotor neuronsastrocytemicrogliaamyotrophic lateral sclerosismotor neuron diseaseABSTRACT Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.Academia Brasileira de Neurologia - ABNEURO2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000849Arquivos de Neuro-Psiquiatria v.74 n.10 2016reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20160117info:eu-repo/semantics/openAccessSouza,Paulo Victor Sgobbi dePinto,Wladimir Bocca Vieira de RezendeRezende Filho,Flávio MouraOliveira,Acary Souza Bulleeng2016-10-14T00:00:00Zoai:scielo:S0004-282X2016001000849Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2016-10-14T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
spellingShingle Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
Souza,Paulo Victor Sgobbi de
motor neurons
astrocyte
microglia
amyotrophic lateral sclerosis
motor neuron disease
title_short Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title_full Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title_fullStr Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title_full_unstemmed Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title_sort Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
author Souza,Paulo Victor Sgobbi de
author_facet Souza,Paulo Victor Sgobbi de
Pinto,Wladimir Bocca Vieira de Rezende
Rezende Filho,Flávio Moura
Oliveira,Acary Souza Bulle
author_role author
author2 Pinto,Wladimir Bocca Vieira de Rezende
Rezende Filho,Flávio Moura
Oliveira,Acary Souza Bulle
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza,Paulo Victor Sgobbi de
Pinto,Wladimir Bocca Vieira de Rezende
Rezende Filho,Flávio Moura
Oliveira,Acary Souza Bulle
dc.subject.por.fl_str_mv motor neurons
astrocyte
microglia
amyotrophic lateral sclerosis
motor neuron disease
topic motor neurons
astrocyte
microglia
amyotrophic lateral sclerosis
motor neuron disease
description ABSTRACT Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000849
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000849
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20160117
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.74 n.10 2016
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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