Motoneuron firing in Amyotrophic Lateral Sclerosis ALS

Detalhes bibliográficos
Autor(a) principal: Carvalho, Mamede
Data de Publicação: 2014
Outros Autores: Eisen, Andrew, Krieger, Charles, Swash, Michael
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50537
Resumo: Copyright © 2014 de Carvalho, Eisen, Krieger and Swash. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Motoneuron firing in Amyotrophic Lateral Sclerosis ALSAmyotrophic lateral sclerosisLower motor neuronMotor cortexMotor units firingUpper motor neuronCopyright © 2014 de Carvalho, Eisen, Krieger and Swash. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Amyotrophic lateral sclerosis is an inexorably progressive neurodegenerative disorder involving the classical motor system and the frontal effector brain, causing muscular weakness and atrophy, with variable upper motor neuron signs and often an associated fronto-temporal dementia. The physiological disturbance consequent on the motor system degeneration is beginning to be well understood. In this review we describe aspects of the motor cortical, neuronal, and lower motor neuron dysfunction. We show how studies of the changes in the pattern of motor unit firing help delineate the underlying pathophysiological disturbance as the disease progresses. Such studies are beginning to illuminate the underlying disordered pathophysiological processes in the disease, and are important in designing new approaches to therapy and especially for clinical trials.FrontiersRepositório da Universidade de LisboaCarvalho, MamedeEisen, AndrewKrieger, CharlesSwash, Michael2021-12-22T15:00:53Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50537engFront Hum Neurosci. 2014 Sep 22;8:71910.3389/fnhum.2014.007191662-5161info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:45Zoai:repositorio.ul.pt:10451/50537Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:57.842640Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Motoneuron firing in Amyotrophic Lateral Sclerosis ALS
title Motoneuron firing in Amyotrophic Lateral Sclerosis ALS
spellingShingle Motoneuron firing in Amyotrophic Lateral Sclerosis ALS
Carvalho, Mamede
Amyotrophic lateral sclerosis
Lower motor neuron
Motor cortex
Motor units firing
Upper motor neuron
title_short Motoneuron firing in Amyotrophic Lateral Sclerosis ALS
title_full Motoneuron firing in Amyotrophic Lateral Sclerosis ALS
title_fullStr Motoneuron firing in Amyotrophic Lateral Sclerosis ALS
title_full_unstemmed Motoneuron firing in Amyotrophic Lateral Sclerosis ALS
title_sort Motoneuron firing in Amyotrophic Lateral Sclerosis ALS
author Carvalho, Mamede
author_facet Carvalho, Mamede
Eisen, Andrew
Krieger, Charles
Swash, Michael
author_role author
author2 Eisen, Andrew
Krieger, Charles
Swash, Michael
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Carvalho, Mamede
Eisen, Andrew
Krieger, Charles
Swash, Michael
dc.subject.por.fl_str_mv Amyotrophic lateral sclerosis
Lower motor neuron
Motor cortex
Motor units firing
Upper motor neuron
topic Amyotrophic lateral sclerosis
Lower motor neuron
Motor cortex
Motor units firing
Upper motor neuron
description Copyright © 2014 de Carvalho, Eisen, Krieger and Swash. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2021-12-22T15:00:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50537
url http://hdl.handle.net/10451/50537
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Hum Neurosci. 2014 Sep 22;8:719
10.3389/fnhum.2014.00719
1662-5161
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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