Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies

• Autor(a) principal: Linden,Vanessa van der
• Data de Publicação: 2017
• Outros Autores: Linden Junior,Hélio van der, Leal,Mariana de Carvalho, Rolim Filho,Epitacio Leite, Linden,Ana van der, Aragão,Maria de Fátima Viana Vasco, Brainer-Lima,Alessandra Mertens, Cruz,Danielle Di Cavalcanti Sousa, Ventura,Liana O., Florêncio,Telma Lúcia Tabosa, Cordeiro,Marli Tenório, Caudas Neto,Silvio da Silva, Ramos,Regina Coeli
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000600381
• topic: Zika virus; Zika virus infection; twins, dizygotic

ABSTRACT Congenital Zika syndrome is an emergent cause of a congenital infectious disorder, resulting in severe damage to the central nervous system and microcephaly. Despite advances in understanding the pathophysiology of the disease, we still do not know all the mechanisms enrolled in the vertical transmission of the virus. As has already been reported in other types of congenital infectious disorders in dizygotic twin pregnancies, it is possible that the virus affects only one of the fetuses. In this article, we report on two cases of twin pregnancies exposed to the Zika virus, but with only one of the fetuses affected with microcephaly and brain damage. This indicates the urgent need for more studies regarding the pathophysiology of viral infection and the mechanisms involved in the natural protection against the virus.