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spelling Zin, Andrea A.Tsui, IrenaRossetto, JuliaVasconcelos, Zilton Farias Meira deAdachi, KristinaValderramos, StephanieHalai, Umme-AimanPone, Marcos Vinicius da SilvaPone, Sheila MouraSilveira Filho, Joel Carlos BarrosAibe, Mitsue S.da Costa, Ana Carolina C.Zin, Olivia A.Belfort, RubensBrasil, PatriciaNielsen-Saines, KarinMoreira, Maria Elisabeth Lopes2017-07-31T17:59:05Z2017-07-31T17:59:05Z2017ZIN, Andrea A. et al. Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection, JAMA Pediatrics, p. E1-E8, Jul. 2017.2168-6211https://www.arca.fiocruz.br/handle/icict/2046610.1001/jamapediatrics.2017.1474engAmerican Medical AssociationZika VirusZika Virus na GravidezAnormalidade OcularZika VirusZika Virus Infection in PregnancyEye abnormalitiesScreening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-07-17Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Pesquisa Clinica. Rio de Janeiro, RJ, Brasil.University of California. Department of Ophthalmology. Los Angeles.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Pesquisa Clinica. Rio de Janeiro, RJ, Brasil / Universidade Federal de São Paulo. Departamento de Oftalmologia, São Paulo, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Pesquisa Clinica. Rio de Janeiro, RJ, Brasil.University of California. Division of Infectious Diseases. Department of Medicine, Los Angeles.University of California. Obstetrics, Gynecology, and Reproductive Sciences Department, San Francisco.University of California. Department of Ophthalmology, Los Angeles.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Universidade Unigranrio. Departamento de Oftalmologia, Rio de Janeiro, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Pesquisa Clinica. Rio de Janeiro, RJ, Brasil.Hospital Federal dos Servidores do Estado. Departamento de Oftalmologia, Rio de Janeiro, Brazil.Federal University of São Paulo. Departamento de Oftalmologia, São Paulo, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.University of California. Division of Infectious Diseases. Department of Medicine, Los Angeles.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Pesquisa Clinica. Rio de Janeiro, RJ, Brasil.Importance: Current guidelines recommend screening eye examinations for infants with microcephaly or laboratory-confirmed Zika virus infection but not for all infants potentially exposed to Zika virus in utero. Objective: To evaluate eye findings in a cohort of infants whose mothers had polymerase chain reaction-confirmed Zika virus infection during pregnancy. Design, setting, and participants: In this descriptive case series performed from January 2 through October 30, 2016, infants were examined from birth to 1 year of age by a multidisciplinary medical team, including a pediatric ophthalmologist, from Fernandes Figueira Institute, a Ministry of Health referral center for high-risk pregnancies and infectious diseases in children in Rio de Janeiro, Brazil. Participants: Mother-infant pairs from Rio de Janeiro, Brazil, who presented with suspected Zika virus infection during pregnancy were referred to our institution and had serum, urine, amniotic fluid, or placenta samples tested by real-time polymerase chain reaction for Zika virus. Main outcomes and measures: Description of eye findings, presence of microcephaly or other central nervous system abnormalities, and timing of infection in infants with confirmed Zika virus during pregnancy. Eye abnormalities were correlated with central nervous system findings, microcephaly, and the timing of maternal infection. Results: Of the 112 with polymerase chain reaction-confirmed Zika virus infection in maternal specimens, 24 infants (21.4%) examined had eye abnormalities (median age at first eye examination, 31 days; range, 0-305 days). Ten infants (41.7%) with eye abnormalities did not have microcephaly, and 8 (33.3%) did not have any central nervous system findings. Fourteen infants with eye abnormalities (58.3%) were born to women infected in the first trimester, 8 (33.3%) in the second trimester, and 2 (8.3%) in the third trimester. Optic nerve and retinal abnormalities were the most frequent findings. Eye abnormalities were statistically associated with microcephaly (odds ratio [OR], 19.1; 95% CI, 6.0-61.0), other central nervous system abnormalities (OR, 4.3; 95% CI, 1.6-11.2), arthrogryposis (OR, 29.0; 95% CI, 3.3-255.8), and maternal trimester of infection (first trimester OR, 5.1; 95% CI, 1.9-13.2; second trimester OR, 0.5; 95% CI, 0.2-1.2; and third trimester OR, 0.3; 95% CI, 0.1-1.2). Conclusions and relevance: Eye abnormalities may be the only initial finding in congenital Zika virus infection. All infants with potential maternal Zika virus exposure at any time during pregnancy should undergo screening eye examinations regardless of the presence or absence of central nervous system abnormalities.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83133https://www.arca.fiocruz.br/bitstream/icict/20466/1/license.txtf74758116b4c371a58ab8be5ab029452MD51ORIGINALve_Andrea_A_Zin_INI_IFF_2017.pdfve_Andrea_A_Zin_INI_IFF_2017.pdfVersão Ahead of Printapplication/pdf1597064https://www.arca.fiocruz.br/bitstream/icict/20466/2/ve_Andrea_A_Zin_INI_IFF_2017.pdfe28da09faae2e28c2eff92fb63ac84d2MD52TEXTve_Andrea_A_Zin_INI_IFF_2017.pdf.txtve_Andrea_A_Zin_INI_IFF_2017.pdf.txtExtracted texttext/plain40114https://www.arca.fiocruz.br/bitstream/icict/20466/3/ve_Andrea_A_Zin_INI_IFF_2017.pdf.txt22e081296f37d28911d5ea24f85afaccMD53icict/204662021-03-24 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dc.title.pt_BR.fl_str_mv Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection
title Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection
spellingShingle Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection
Zin, Andrea A.
Zika Virus
Zika Virus na Gravidez
Anormalidade Ocular
Zika Virus
Zika Virus Infection in Pregnancy
Eye abnormalities
title_short Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection
title_full Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection
title_fullStr Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection
title_full_unstemmed Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection
title_sort Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection
author Zin, Andrea A.
author_facet Zin, Andrea A.
Tsui, Irena
Rossetto, Julia
Vasconcelos, Zilton Farias Meira de
Adachi, Kristina
Valderramos, Stephanie
Halai, Umme-Aiman
Pone, Marcos Vinicius da Silva
Pone, Sheila Moura
Silveira Filho, Joel Carlos Barros
Aibe, Mitsue S.
da Costa, Ana Carolina C.
Zin, Olivia A.
Belfort, Rubens
Brasil, Patricia
Nielsen-Saines, Karin
Moreira, Maria Elisabeth Lopes
author_role author
author2 Tsui, Irena
Rossetto, Julia
Vasconcelos, Zilton Farias Meira de
Adachi, Kristina
Valderramos, Stephanie
Halai, Umme-Aiman
Pone, Marcos Vinicius da Silva
Pone, Sheila Moura
Silveira Filho, Joel Carlos Barros
Aibe, Mitsue S.
da Costa, Ana Carolina C.
Zin, Olivia A.
Belfort, Rubens
Brasil, Patricia
Nielsen-Saines, Karin
Moreira, Maria Elisabeth Lopes
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zin, Andrea A.
Tsui, Irena
Rossetto, Julia
Vasconcelos, Zilton Farias Meira de
Adachi, Kristina
Valderramos, Stephanie
Halai, Umme-Aiman
Pone, Marcos Vinicius da Silva
Pone, Sheila Moura
Silveira Filho, Joel Carlos Barros
Aibe, Mitsue S.
da Costa, Ana Carolina C.
Zin, Olivia A.
Belfort, Rubens
Brasil, Patricia
Nielsen-Saines, Karin
Moreira, Maria Elisabeth Lopes
dc.subject.other.pt_BR.fl_str_mv Zika Virus
Zika Virus na Gravidez
Anormalidade Ocular
topic Zika Virus
Zika Virus na Gravidez
Anormalidade Ocular
Zika Virus
Zika Virus Infection in Pregnancy
Eye abnormalities
dc.subject.en.pt_BR.fl_str_mv Zika Virus
Zika Virus Infection in Pregnancy
Eye abnormalities
description 2018-07-17
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-07-31T17:59:05Z
dc.date.available.fl_str_mv 2017-07-31T17:59:05Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ZIN, Andrea A. et al. Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection, JAMA Pediatrics, p. E1-E8, Jul. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20466
dc.identifier.issn.pt_BR.fl_str_mv 2168-6211
dc.identifier.doi.none.fl_str_mv 10.1001/jamapediatrics.2017.1474
identifier_str_mv ZIN, Andrea A. et al. Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection, JAMA Pediatrics, p. E1-E8, Jul. 2017.
2168-6211
10.1001/jamapediatrics.2017.1474
url https://www.arca.fiocruz.br/handle/icict/20466
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Medical Association
publisher.none.fl_str_mv American Medical Association
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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