Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis

Detalhes bibliográficos
Autor(a) principal: Leon-Sarmiento,Fidias E.
Data de Publicação: 2008
Outros Autores: Calderon,Andres, Hernandez,Hernan G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016
Resumo: Tropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) - associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients.
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spelling Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesisHAMTSPBabinski plus signmycotoxinsneurorehabilitationTropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) - associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients.Academia Brasileira de Neurologia - ABNEURO2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016Arquivos de Neuro-Psiquiatria v.66 n.3b 2008reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2008000500016info:eu-repo/semantics/openAccessLeon-Sarmiento,Fidias E.Calderon,AndresHernandez,Hernan G.eng2008-10-15T00:00:00Zoai:scielo:S0004-282X2008000500016Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-10-15T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis
title Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis
spellingShingle Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis
Leon-Sarmiento,Fidias E.
HAM
TSP
Babinski plus sign
mycotoxins
neurorehabilitation
title_short Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis
title_full Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis
title_fullStr Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis
title_full_unstemmed Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis
title_sort Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis
author Leon-Sarmiento,Fidias E.
author_facet Leon-Sarmiento,Fidias E.
Calderon,Andres
Hernandez,Hernan G.
author_role author
author2 Calderon,Andres
Hernandez,Hernan G.
author2_role author
author
dc.contributor.author.fl_str_mv Leon-Sarmiento,Fidias E.
Calderon,Andres
Hernandez,Hernan G.
dc.subject.por.fl_str_mv HAM
TSP
Babinski plus sign
mycotoxins
neurorehabilitation
topic HAM
TSP
Babinski plus sign
mycotoxins
neurorehabilitation
description Tropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) - associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2008000500016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.66 n.3b 2008
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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