Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016 |
Resumo: | Tropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) - associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients. |
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Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesisHAMTSPBabinski plus signmycotoxinsneurorehabilitationTropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) - associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients.Academia Brasileira de Neurologia - ABNEURO2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016Arquivos de Neuro-Psiquiatria v.66 n.3b 2008reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2008000500016info:eu-repo/semantics/openAccessLeon-Sarmiento,Fidias E.Calderon,AndresHernandez,Hernan G.eng2008-10-15T00:00:00Zoai:scielo:S0004-282X2008000500016Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-10-15T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis |
title |
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis |
spellingShingle |
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis Leon-Sarmiento,Fidias E. HAM TSP Babinski plus sign mycotoxins neurorehabilitation |
title_short |
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis |
title_full |
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis |
title_fullStr |
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis |
title_full_unstemmed |
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis |
title_sort |
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis |
author |
Leon-Sarmiento,Fidias E. |
author_facet |
Leon-Sarmiento,Fidias E. Calderon,Andres Hernandez,Hernan G. |
author_role |
author |
author2 |
Calderon,Andres Hernandez,Hernan G. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Leon-Sarmiento,Fidias E. Calderon,Andres Hernandez,Hernan G. |
dc.subject.por.fl_str_mv |
HAM TSP Babinski plus sign mycotoxins neurorehabilitation |
topic |
HAM TSP Babinski plus sign mycotoxins neurorehabilitation |
description |
Tropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) - associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000500016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2008000500016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.66 n.3b 2008 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212764596830208 |