Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact

Detalhes bibliográficos
Autor(a) principal: Rojas,Juan Ignacio
Data de Publicação: 2016
Outros Autores: Patrucco,Liliana, Miguez,Jimena, Cristiano,Edgardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000300011
Resumo: ABSTRACT Multiple sclerosis (MS) was always considered as a white matter inflammatory disease. Today, there is an important body of evidence that supports the hypothesis that gray matter involvement and the neurodegenerative mechanism are at least partially independent from inflammation. Gray matter atrophy develops faster than white matter atrophy, and predominates in the initial stages of the disease. The neurodegenerative mechanism creates permanent damage and correlates with physical and cognitive disability. In this review we describe the current available evidence regarding brain atrophy and its consequence in MS patients.
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spelling Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impactmultiple sclerosisbrain atrophyneurodegenerationABSTRACT Multiple sclerosis (MS) was always considered as a white matter inflammatory disease. Today, there is an important body of evidence that supports the hypothesis that gray matter involvement and the neurodegenerative mechanism are at least partially independent from inflammation. Gray matter atrophy develops faster than white matter atrophy, and predominates in the initial stages of the disease. The neurodegenerative mechanism creates permanent damage and correlates with physical and cognitive disability. In this review we describe the current available evidence regarding brain atrophy and its consequence in MS patients.Academia Brasileira de Neurologia - ABNEURO2016-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000300011Arquivos de Neuro-Psiquiatria v.74 n.3 2016reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20160015info:eu-repo/semantics/openAccessRojas,Juan IgnacioPatrucco,LilianaMiguez,JimenaCristiano,Edgardoeng2016-03-23T00:00:00Zoai:scielo:S0004-282X2016000300011Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2016-03-23T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
title Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
spellingShingle Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
Rojas,Juan Ignacio
multiple sclerosis
brain atrophy
neurodegeneration
title_short Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
title_full Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
title_fullStr Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
title_full_unstemmed Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
title_sort Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
author Rojas,Juan Ignacio
author_facet Rojas,Juan Ignacio
Patrucco,Liliana
Miguez,Jimena
Cristiano,Edgardo
author_role author
author2 Patrucco,Liliana
Miguez,Jimena
Cristiano,Edgardo
author2_role author
author
author
dc.contributor.author.fl_str_mv Rojas,Juan Ignacio
Patrucco,Liliana
Miguez,Jimena
Cristiano,Edgardo
dc.subject.por.fl_str_mv multiple sclerosis
brain atrophy
neurodegeneration
topic multiple sclerosis
brain atrophy
neurodegeneration
description ABSTRACT Multiple sclerosis (MS) was always considered as a white matter inflammatory disease. Today, there is an important body of evidence that supports the hypothesis that gray matter involvement and the neurodegenerative mechanism are at least partially independent from inflammation. Gray matter atrophy develops faster than white matter atrophy, and predominates in the initial stages of the disease. The neurodegenerative mechanism creates permanent damage and correlates with physical and cognitive disability. In this review we describe the current available evidence regarding brain atrophy and its consequence in MS patients.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000300011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000300011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20160015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.74 n.3 2016
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
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institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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