Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000900837 |
Resumo: | Abstract Background The Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy that manifests as a rapidly progressive dementia syndrome. Currently, CJD has no cure, and many patients die within the first year, but some drugs are being studied as options for managing this condition. Objective To evaluate the effectiveness of pharmacological treatments offered to patients with CJD as a means to increase survival and reduce cognitive deterioration. Methods A systematic review of the literature was performed using 4 independent reviewers and 1 extra reviewer to resolve possible divergences in the search and analysis of papers indexed in MedLINE (PubMed), SciELO and Lilacs databases. The Medical Subject Heading (MeSH) terms used were: prion diseases, Creutzfeldt-Jakob disease, pharmacologic therapy, therapeutics, quinacrine, doxycycline, flupirtine, and pentosan polysulfate, with the Boolean operators AND and OR. This search included controlled clinical trials, uncontrolled clinical trials, and case series published from the year 2000 onwards, in the English language. Results A total of 85 papers were found using the descriptors used. At the end of the selection analyses, 9 articles remained, which were analyzed fully and individually. Conclusions None of the drugs evaluated proved significantly effective in increasing survival in patients with CJD. Flupirtine appears to have a beneficial effect in reducing cognitive deterioration in patients with CJD. However, additional studies are needed to establish better evidence and therapeutic options for the management of patients with CJD. |
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Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?Creutzfeldt-Jakob SyndromePrion DiseasesTherapeuticsAbstract Background The Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy that manifests as a rapidly progressive dementia syndrome. Currently, CJD has no cure, and many patients die within the first year, but some drugs are being studied as options for managing this condition. Objective To evaluate the effectiveness of pharmacological treatments offered to patients with CJD as a means to increase survival and reduce cognitive deterioration. Methods A systematic review of the literature was performed using 4 independent reviewers and 1 extra reviewer to resolve possible divergences in the search and analysis of papers indexed in MedLINE (PubMed), SciELO and Lilacs databases. The Medical Subject Heading (MeSH) terms used were: prion diseases, Creutzfeldt-Jakob disease, pharmacologic therapy, therapeutics, quinacrine, doxycycline, flupirtine, and pentosan polysulfate, with the Boolean operators AND and OR. This search included controlled clinical trials, uncontrolled clinical trials, and case series published from the year 2000 onwards, in the English language. Results A total of 85 papers were found using the descriptors used. At the end of the selection analyses, 9 articles remained, which were analyzed fully and individually. Conclusions None of the drugs evaluated proved significantly effective in increasing survival in patients with CJD. Flupirtine appears to have a beneficial effect in reducing cognitive deterioration in patients with CJD. However, additional studies are needed to establish better evidence and therapeutic options for the management of patients with CJD.Academia Brasileira de Neurologia - ABNEURO2022-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000900837Arquivos de Neuro-Psiquiatria v.80 n.8 2022reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1055/s-0042-1755341info:eu-repo/semantics/openAccessMiranda,Luiz Henrique LélisOliveira,André Felipe Pastick de HolandaCarvalho,Davi Mariano deSouza,Gustavo Marques FigueredoMagalhães,João Guilherme MonteiroCabral Júnior,Joselmo AlbertoLima,Pedro Thadeu Mertens Brainer de QueirozAguiar Júnior,Renato MeloLins Filho,Sérgio PereiraMelo,Hugo Moura de Albuquerqueeng2022-11-18T00:00:00Zoai:scielo:S0004-282X2022000900837Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2022-11-18T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? |
title |
Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? |
spellingShingle |
Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? Miranda,Luiz Henrique Lélis Creutzfeldt-Jakob Syndrome Prion Diseases Therapeutics |
title_short |
Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? |
title_full |
Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? |
title_fullStr |
Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? |
title_full_unstemmed |
Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? |
title_sort |
Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? |
author |
Miranda,Luiz Henrique Lélis |
author_facet |
Miranda,Luiz Henrique Lélis Oliveira,André Felipe Pastick de Holanda Carvalho,Davi Mariano de Souza,Gustavo Marques Figueredo Magalhães,João Guilherme Monteiro Cabral Júnior,Joselmo Alberto Lima,Pedro Thadeu Mertens Brainer de Queiroz Aguiar Júnior,Renato Melo Lins Filho,Sérgio Pereira Melo,Hugo Moura de Albuquerque |
author_role |
author |
author2 |
Oliveira,André Felipe Pastick de Holanda Carvalho,Davi Mariano de Souza,Gustavo Marques Figueredo Magalhães,João Guilherme Monteiro Cabral Júnior,Joselmo Alberto Lima,Pedro Thadeu Mertens Brainer de Queiroz Aguiar Júnior,Renato Melo Lins Filho,Sérgio Pereira Melo,Hugo Moura de Albuquerque |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Miranda,Luiz Henrique Lélis Oliveira,André Felipe Pastick de Holanda Carvalho,Davi Mariano de Souza,Gustavo Marques Figueredo Magalhães,João Guilherme Monteiro Cabral Júnior,Joselmo Alberto Lima,Pedro Thadeu Mertens Brainer de Queiroz Aguiar Júnior,Renato Melo Lins Filho,Sérgio Pereira Melo,Hugo Moura de Albuquerque |
dc.subject.por.fl_str_mv |
Creutzfeldt-Jakob Syndrome Prion Diseases Therapeutics |
topic |
Creutzfeldt-Jakob Syndrome Prion Diseases Therapeutics |
description |
Abstract Background The Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy that manifests as a rapidly progressive dementia syndrome. Currently, CJD has no cure, and many patients die within the first year, but some drugs are being studied as options for managing this condition. Objective To evaluate the effectiveness of pharmacological treatments offered to patients with CJD as a means to increase survival and reduce cognitive deterioration. Methods A systematic review of the literature was performed using 4 independent reviewers and 1 extra reviewer to resolve possible divergences in the search and analysis of papers indexed in MedLINE (PubMed), SciELO and Lilacs databases. The Medical Subject Heading (MeSH) terms used were: prion diseases, Creutzfeldt-Jakob disease, pharmacologic therapy, therapeutics, quinacrine, doxycycline, flupirtine, and pentosan polysulfate, with the Boolean operators AND and OR. This search included controlled clinical trials, uncontrolled clinical trials, and case series published from the year 2000 onwards, in the English language. Results A total of 85 papers were found using the descriptors used. At the end of the selection analyses, 9 articles remained, which were analyzed fully and individually. Conclusions None of the drugs evaluated proved significantly effective in increasing survival in patients with CJD. Flupirtine appears to have a beneficial effect in reducing cognitive deterioration in patients with CJD. However, additional studies are needed to establish better evidence and therapeutic options for the management of patients with CJD. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000900837 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000900837 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1055/s-0042-1755341 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.80 n.8 2022 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
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ABNEURO |
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Arquivos de neuro-psiquiatria (Online) |
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Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
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