Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?

Detalhes bibliográficos
Autor(a) principal: Miranda,Luiz Henrique Lélis
Data de Publicação: 2022
Outros Autores: Oliveira,André Felipe Pastick de Holanda, Carvalho,Davi Mariano de, Souza,Gustavo Marques Figueredo, Magalhães,João Guilherme Monteiro, Cabral Júnior,Joselmo Alberto, Lima,Pedro Thadeu Mertens Brainer de Queiroz, Aguiar Júnior,Renato Melo, Lins Filho,Sérgio Pereira, Melo,Hugo Moura de Albuquerque
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000900837
Resumo: Abstract Background The Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy that manifests as a rapidly progressive dementia syndrome. Currently, CJD has no cure, and many patients die within the first year, but some drugs are being studied as options for managing this condition. Objective To evaluate the effectiveness of pharmacological treatments offered to patients with CJD as a means to increase survival and reduce cognitive deterioration. Methods A systematic review of the literature was performed using 4 independent reviewers and 1 extra reviewer to resolve possible divergences in the search and analysis of papers indexed in MedLINE (PubMed), SciELO and Lilacs databases. The Medical Subject Heading (MeSH) terms used were: prion diseases, Creutzfeldt-Jakob disease, pharmacologic therapy, therapeutics, quinacrine, doxycycline, flupirtine, and pentosan polysulfate, with the Boolean operators AND and OR. This search included controlled clinical trials, uncontrolled clinical trials, and case series published from the year 2000 onwards, in the English language. Results A total of 85 papers were found using the descriptors used. At the end of the selection analyses, 9 articles remained, which were analyzed fully and individually. Conclusions None of the drugs evaluated proved significantly effective in increasing survival in patients with CJD. Flupirtine appears to have a beneficial effect in reducing cognitive deterioration in patients with CJD. However, additional studies are needed to establish better evidence and therapeutic options for the management of patients with CJD.
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spelling Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?Creutzfeldt-Jakob SyndromePrion DiseasesTherapeuticsAbstract Background The Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy that manifests as a rapidly progressive dementia syndrome. Currently, CJD has no cure, and many patients die within the first year, but some drugs are being studied as options for managing this condition. Objective To evaluate the effectiveness of pharmacological treatments offered to patients with CJD as a means to increase survival and reduce cognitive deterioration. Methods A systematic review of the literature was performed using 4 independent reviewers and 1 extra reviewer to resolve possible divergences in the search and analysis of papers indexed in MedLINE (PubMed), SciELO and Lilacs databases. The Medical Subject Heading (MeSH) terms used were: prion diseases, Creutzfeldt-Jakob disease, pharmacologic therapy, therapeutics, quinacrine, doxycycline, flupirtine, and pentosan polysulfate, with the Boolean operators AND and OR. This search included controlled clinical trials, uncontrolled clinical trials, and case series published from the year 2000 onwards, in the English language. Results A total of 85 papers were found using the descriptors used. At the end of the selection analyses, 9 articles remained, which were analyzed fully and individually. Conclusions None of the drugs evaluated proved significantly effective in increasing survival in patients with CJD. Flupirtine appears to have a beneficial effect in reducing cognitive deterioration in patients with CJD. However, additional studies are needed to establish better evidence and therapeutic options for the management of patients with CJD.Academia Brasileira de Neurologia - ABNEURO2022-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000900837Arquivos de Neuro-Psiquiatria v.80 n.8 2022reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1055/s-0042-1755341info:eu-repo/semantics/openAccessMiranda,Luiz Henrique LélisOliveira,André Felipe Pastick de HolandaCarvalho,Davi Mariano deSouza,Gustavo Marques FigueredoMagalhães,João Guilherme MonteiroCabral Júnior,Joselmo AlbertoLima,Pedro Thadeu Mertens Brainer de QueirozAguiar Júnior,Renato MeloLins Filho,Sérgio PereiraMelo,Hugo Moura de Albuquerqueeng2022-11-18T00:00:00Zoai:scielo:S0004-282X2022000900837Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2022-11-18T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
title Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
spellingShingle Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
Miranda,Luiz Henrique Lélis
Creutzfeldt-Jakob Syndrome
Prion Diseases
Therapeutics
title_short Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
title_full Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
title_fullStr Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
title_full_unstemmed Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
title_sort Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
author Miranda,Luiz Henrique Lélis
author_facet Miranda,Luiz Henrique Lélis
Oliveira,André Felipe Pastick de Holanda
Carvalho,Davi Mariano de
Souza,Gustavo Marques Figueredo
Magalhães,João Guilherme Monteiro
Cabral Júnior,Joselmo Alberto
Lima,Pedro Thadeu Mertens Brainer de Queiroz
Aguiar Júnior,Renato Melo
Lins Filho,Sérgio Pereira
Melo,Hugo Moura de Albuquerque
author_role author
author2 Oliveira,André Felipe Pastick de Holanda
Carvalho,Davi Mariano de
Souza,Gustavo Marques Figueredo
Magalhães,João Guilherme Monteiro
Cabral Júnior,Joselmo Alberto
Lima,Pedro Thadeu Mertens Brainer de Queiroz
Aguiar Júnior,Renato Melo
Lins Filho,Sérgio Pereira
Melo,Hugo Moura de Albuquerque
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Miranda,Luiz Henrique Lélis
Oliveira,André Felipe Pastick de Holanda
Carvalho,Davi Mariano de
Souza,Gustavo Marques Figueredo
Magalhães,João Guilherme Monteiro
Cabral Júnior,Joselmo Alberto
Lima,Pedro Thadeu Mertens Brainer de Queiroz
Aguiar Júnior,Renato Melo
Lins Filho,Sérgio Pereira
Melo,Hugo Moura de Albuquerque
dc.subject.por.fl_str_mv Creutzfeldt-Jakob Syndrome
Prion Diseases
Therapeutics
topic Creutzfeldt-Jakob Syndrome
Prion Diseases
Therapeutics
description Abstract Background The Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy that manifests as a rapidly progressive dementia syndrome. Currently, CJD has no cure, and many patients die within the first year, but some drugs are being studied as options for managing this condition. Objective To evaluate the effectiveness of pharmacological treatments offered to patients with CJD as a means to increase survival and reduce cognitive deterioration. Methods A systematic review of the literature was performed using 4 independent reviewers and 1 extra reviewer to resolve possible divergences in the search and analysis of papers indexed in MedLINE (PubMed), SciELO and Lilacs databases. The Medical Subject Heading (MeSH) terms used were: prion diseases, Creutzfeldt-Jakob disease, pharmacologic therapy, therapeutics, quinacrine, doxycycline, flupirtine, and pentosan polysulfate, with the Boolean operators AND and OR. This search included controlled clinical trials, uncontrolled clinical trials, and case series published from the year 2000 onwards, in the English language. Results A total of 85 papers were found using the descriptors used. At the end of the selection analyses, 9 articles remained, which were analyzed fully and individually. Conclusions None of the drugs evaluated proved significantly effective in increasing survival in patients with CJD. Flupirtine appears to have a beneficial effect in reducing cognitive deterioration in patients with CJD. However, additional studies are needed to establish better evidence and therapeutic options for the management of patients with CJD.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000900837
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1055/s-0042-1755341
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.80 n.8 2022
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
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reponame_str Arquivos de neuro-psiquiatria (Online)
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repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
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