Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil

• Autor(a) principal: Vidal,Luine Rosele Renaud
• Data de Publicação: 2011
• Outros Autores: Almeida,Sérgio Monteiro de, Messias-Reason,Iara José de, Nogueira,Meri Bordignon, Debur,Maria do Carmo, Pessa,Luís Felipe Cavalli, Pereira,Luciane Aparecida, Rotta,Indianara, Takahashi,Gislene Reche de Almeida, Silveira,Clyete Santos da, Araújo,Josianne Maria Reimann, Raboni,Sonia Mara
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000400013
• topic: aseptic meningitis; lymphocytic meningitis; lymphomonocytary meningitis; cerebrospinal fluid; central nervous system; enterovirus; herpesvirus

Viral meningitis is a common infectious disease of the central nervous system (CNS) that occurs worldwide. The aim of this study was to identify the etiologic agent of lymphomonocytary meningitis in Curitiba, PR, Brazil. During the period of July 2005 to December 2006, 460 cerebrospinal fluid (CSF) samples with lymphomonocytary meningitis were analyzed by PCR methodologies. Fifty nine (12.8%) samples were positive. Enteroviruses was present in 49 (83%) samples and herpes virus family in 10 (17%), of these 6 (10%) herpes simplex virus, 1 (2%) Epstein Barr virus, 2 (3%) human herpes virus type 6 and 1 (2%) mixed infection of enterovirus and Epstein Barr virus. As conclusion enterovirus was the most frequent virus, with circulation during summer and was observed with higher frequency between 4 to 17 years of age. PCR methodology is an important method for rapid detection of RNA enterovirus and DNA herpesvirus in CSF.