Morphometry MRI in the differential diagnosis of parkinsonian syndromes
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000300001 |
Resumo: | This study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). We studied 21 PD cases, 11 MSA-c, 8 MSA-p and 20 PSP cases. Midbrain area (Ams), pons area (Apn), middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP) were measured using MRI. Comparisons were made between PD, MSA-p, MSA-c and PSP. Apn, MCP and SCP morphometry dimensions presented differences among groups. Ams below 105 mm² and SCP smaller than 3 mmwere the most predictive measures of PSP (sensitivity 95.0 and 80.0%, respectively). For the group of MSA-c patients, Apn area below 315 mm² showed good specificity and positive predictive value (93.8% and 72.7%, respectively). In conclusion, dimensions and cut off values obtained from routine MRI can differentiate between PD, PSP and MSA-c with good sensitivity, specificity and accuracy. |
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Morphometry MRI in the differential diagnosis of parkinsonian syndromesParkinsonmultiple system atrophyprogressive supranuclear palsymagnetic resonance imagingponsmidbrainThis study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). We studied 21 PD cases, 11 MSA-c, 8 MSA-p and 20 PSP cases. Midbrain area (Ams), pons area (Apn), middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP) were measured using MRI. Comparisons were made between PD, MSA-p, MSA-c and PSP. Apn, MCP and SCP morphometry dimensions presented differences among groups. Ams below 105 mm² and SCP smaller than 3 mmwere the most predictive measures of PSP (sensitivity 95.0 and 80.0%, respectively). For the group of MSA-c patients, Apn area below 315 mm² showed good specificity and positive predictive value (93.8% and 72.7%, respectively). In conclusion, dimensions and cut off values obtained from routine MRI can differentiate between PD, PSP and MSA-c with good sensitivity, specificity and accuracy.Academia Brasileira de Neurologia - ABNEURO2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000300001Arquivos de Neuro-Psiquiatria v.68 n.3 2010reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2010000300001info:eu-repo/semantics/openAccessGama,Rômulo LTávora,Daniel F.GBomfim,Rodrigo CSilva,Cruiff EBruin,Veralice M. deBruin,Pedro F. deeng2010-06-24T00:00:00Zoai:scielo:S0004-282X2010000300001Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-06-24T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Morphometry MRI in the differential diagnosis of parkinsonian syndromes |
title |
Morphometry MRI in the differential diagnosis of parkinsonian syndromes |
spellingShingle |
Morphometry MRI in the differential diagnosis of parkinsonian syndromes Gama,Rômulo L Parkinson multiple system atrophy progressive supranuclear palsy magnetic resonance imaging pons midbrain |
title_short |
Morphometry MRI in the differential diagnosis of parkinsonian syndromes |
title_full |
Morphometry MRI in the differential diagnosis of parkinsonian syndromes |
title_fullStr |
Morphometry MRI in the differential diagnosis of parkinsonian syndromes |
title_full_unstemmed |
Morphometry MRI in the differential diagnosis of parkinsonian syndromes |
title_sort |
Morphometry MRI in the differential diagnosis of parkinsonian syndromes |
author |
Gama,Rômulo L |
author_facet |
Gama,Rômulo L Távora,Daniel F.G Bomfim,Rodrigo C Silva,Cruiff E Bruin,Veralice M. de Bruin,Pedro F. de |
author_role |
author |
author2 |
Távora,Daniel F.G Bomfim,Rodrigo C Silva,Cruiff E Bruin,Veralice M. de Bruin,Pedro F. de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gama,Rômulo L Távora,Daniel F.G Bomfim,Rodrigo C Silva,Cruiff E Bruin,Veralice M. de Bruin,Pedro F. de |
dc.subject.por.fl_str_mv |
Parkinson multiple system atrophy progressive supranuclear palsy magnetic resonance imaging pons midbrain |
topic |
Parkinson multiple system atrophy progressive supranuclear palsy magnetic resonance imaging pons midbrain |
description |
This study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). We studied 21 PD cases, 11 MSA-c, 8 MSA-p and 20 PSP cases. Midbrain area (Ams), pons area (Apn), middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP) were measured using MRI. Comparisons were made between PD, MSA-p, MSA-c and PSP. Apn, MCP and SCP morphometry dimensions presented differences among groups. Ams below 105 mm² and SCP smaller than 3 mmwere the most predictive measures of PSP (sensitivity 95.0 and 80.0%, respectively). For the group of MSA-c patients, Apn area below 315 mm² showed good specificity and positive predictive value (93.8% and 72.7%, respectively). In conclusion, dimensions and cut off values obtained from routine MRI can differentiate between PD, PSP and MSA-c with good sensitivity, specificity and accuracy. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000300001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000300001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2010000300001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.68 n.3 2010 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212768440909824 |