Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system

Detalhes bibliográficos
Autor(a) principal: Almeida,Sérgio Monteiro de
Data de Publicação: 2015
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700624
Resumo: The nervous system plays an important role in HIV infection. The purpose of this review is to discuss the indications for cerebrospinal fluid (CSF) analysis in HIV infection in clinical practice. CSF analysis in HIV infection is indicated for the diagnosis of opportunistic infections and co-infections, diagnosis of meningitis caused by HIV, quantification of HIV viral load, and analysis of CNS HIV compartmentalization. Although several CSF biomarkers have been investigated, none are clinically applicable. The capacity of HIV to generate genetic diversity, in association with the constitutional characteristics of the CNS, facilitates the generation of HIV quasispecies in the CNS that are distinct from HIV in the systemic circulation. CSF analysis has a well-defined and valuable role in the diagnosis of CNS infections in HIV/AIDS patients. Further research is necessary to establish a clinically applicable biomarker for the diagnosis of HIV-associated neurocognitive disorders.
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spelling Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous systemHIVAIDScentral nervous systemcognitive impairmentcerebrospinal fluidviral loadbiomarkersThe nervous system plays an important role in HIV infection. The purpose of this review is to discuss the indications for cerebrospinal fluid (CSF) analysis in HIV infection in clinical practice. CSF analysis in HIV infection is indicated for the diagnosis of opportunistic infections and co-infections, diagnosis of meningitis caused by HIV, quantification of HIV viral load, and analysis of CNS HIV compartmentalization. Although several CSF biomarkers have been investigated, none are clinically applicable. The capacity of HIV to generate genetic diversity, in association with the constitutional characteristics of the CNS, facilitates the generation of HIV quasispecies in the CNS that are distinct from HIV in the systemic circulation. CSF analysis has a well-defined and valuable role in the diagnosis of CNS infections in HIV/AIDS patients. Further research is necessary to establish a clinically applicable biomarker for the diagnosis of HIV-associated neurocognitive disorders.Academia Brasileira de Neurologia - ABNEURO2015-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700624Arquivos de Neuro-Psiquiatria v.73 n.7 2015reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20150071info:eu-repo/semantics/openAccessAlmeida,Sérgio Monteiro deeng2015-07-16T00:00:00Zoai:scielo:S0004-282X2015000700624Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-07-16T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system
title Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system
spellingShingle Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system
Almeida,Sérgio Monteiro de
HIV
AIDS
central nervous system
cognitive impairment
cerebrospinal fluid
viral load
biomarkers
title_short Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system
title_full Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system
title_fullStr Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system
title_full_unstemmed Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system
title_sort Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system
author Almeida,Sérgio Monteiro de
author_facet Almeida,Sérgio Monteiro de
author_role author
dc.contributor.author.fl_str_mv Almeida,Sérgio Monteiro de
dc.subject.por.fl_str_mv HIV
AIDS
central nervous system
cognitive impairment
cerebrospinal fluid
viral load
biomarkers
topic HIV
AIDS
central nervous system
cognitive impairment
cerebrospinal fluid
viral load
biomarkers
description The nervous system plays an important role in HIV infection. The purpose of this review is to discuss the indications for cerebrospinal fluid (CSF) analysis in HIV infection in clinical practice. CSF analysis in HIV infection is indicated for the diagnosis of opportunistic infections and co-infections, diagnosis of meningitis caused by HIV, quantification of HIV viral load, and analysis of CNS HIV compartmentalization. Although several CSF biomarkers have been investigated, none are clinically applicable. The capacity of HIV to generate genetic diversity, in association with the constitutional characteristics of the CNS, facilitates the generation of HIV quasispecies in the CNS that are distinct from HIV in the systemic circulation. CSF analysis has a well-defined and valuable role in the diagnosis of CNS infections in HIV/AIDS patients. Further research is necessary to establish a clinically applicable biomarker for the diagnosis of HIV-associated neurocognitive disorders.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700624
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000700624
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20150071
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.73 n.7 2015
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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