Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission

Detalhes bibliográficos
Autor(a) principal: Brandão,Carlos Otávio
Data de Publicação: 2005
Outros Autores: Ruocco,Heloísa Helena, Farias,Alessandro dos Santos, Oliveira,Celina, Hallal-Longo,Dannie Eiko Maeda, Mirandola,Sandra Regina, Oliveira,Elaine Conceição, Cendes,Fernando, Damasceno,Benito Pereira, Santos,Leonilda Maria Barbosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000600002
Resumo: Cytokines and intrathecal IgG synthesis were determined in the cerebrospinal fluid (CSF) and sera to evaluate inflammatory activity in multiple sclerosis (MS) patients during clinical remission. Although the disease was stable, there had been a significant increase of proinflammatory cytokines such as TNFalpha and IFNgamma in the CSF and serum, with no significant changes of IL12 and IL10 production. The changes in the cytokine production patterns were associated with an increase of leukocytes in the CSF, as well as the presence of oligoclonal bands suggesting intrathecal IgG synthesis. These results suggest that even when the disease is clinically silent, one can observe inflammatory activity in these MS patients.
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spelling Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remissionmultiple sclerosiscerebrospinal fluidcytokinesintrathecal IgG synthesisCytokines and intrathecal IgG synthesis were determined in the cerebrospinal fluid (CSF) and sera to evaluate inflammatory activity in multiple sclerosis (MS) patients during clinical remission. Although the disease was stable, there had been a significant increase of proinflammatory cytokines such as TNFalpha and IFNgamma in the CSF and serum, with no significant changes of IL12 and IL10 production. The changes in the cytokine production patterns were associated with an increase of leukocytes in the CSF, as well as the presence of oligoclonal bands suggesting intrathecal IgG synthesis. These results suggest that even when the disease is clinically silent, one can observe inflammatory activity in these MS patients.Academia Brasileira de Neurologia - ABNEURO2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000600002Arquivos de Neuro-Psiquiatria v.63 n.4 2005reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2005000600002info:eu-repo/semantics/openAccessBrandão,Carlos OtávioRuocco,Heloísa HelenaFarias,Alessandro dos SantosOliveira,CelinaHallal-Longo,Dannie Eiko MaedaMirandola,Sandra ReginaOliveira,Elaine ConceiçãoCendes,FernandoDamasceno,Benito PereiraSantos,Leonilda Maria Barbosaeng2006-01-09T00:00:00Zoai:scielo:S0004-282X2005000600002Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2006-01-09T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
title Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
spellingShingle Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
Brandão,Carlos Otávio
multiple sclerosis
cerebrospinal fluid
cytokines
intrathecal IgG synthesis
title_short Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
title_full Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
title_fullStr Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
title_full_unstemmed Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
title_sort Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
author Brandão,Carlos Otávio
author_facet Brandão,Carlos Otávio
Ruocco,Heloísa Helena
Farias,Alessandro dos Santos
Oliveira,Celina
Hallal-Longo,Dannie Eiko Maeda
Mirandola,Sandra Regina
Oliveira,Elaine Conceição
Cendes,Fernando
Damasceno,Benito Pereira
Santos,Leonilda Maria Barbosa
author_role author
author2 Ruocco,Heloísa Helena
Farias,Alessandro dos Santos
Oliveira,Celina
Hallal-Longo,Dannie Eiko Maeda
Mirandola,Sandra Regina
Oliveira,Elaine Conceição
Cendes,Fernando
Damasceno,Benito Pereira
Santos,Leonilda Maria Barbosa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brandão,Carlos Otávio
Ruocco,Heloísa Helena
Farias,Alessandro dos Santos
Oliveira,Celina
Hallal-Longo,Dannie Eiko Maeda
Mirandola,Sandra Regina
Oliveira,Elaine Conceição
Cendes,Fernando
Damasceno,Benito Pereira
Santos,Leonilda Maria Barbosa
dc.subject.por.fl_str_mv multiple sclerosis
cerebrospinal fluid
cytokines
intrathecal IgG synthesis
topic multiple sclerosis
cerebrospinal fluid
cytokines
intrathecal IgG synthesis
description Cytokines and intrathecal IgG synthesis were determined in the cerebrospinal fluid (CSF) and sera to evaluate inflammatory activity in multiple sclerosis (MS) patients during clinical remission. Although the disease was stable, there had been a significant increase of proinflammatory cytokines such as TNFalpha and IFNgamma in the CSF and serum, with no significant changes of IL12 and IL10 production. The changes in the cytokine production patterns were associated with an increase of leukocytes in the CSF, as well as the presence of oligoclonal bands suggesting intrathecal IgG synthesis. These results suggest that even when the disease is clinically silent, one can observe inflammatory activity in these MS patients.
publishDate 2005
dc.date.none.fl_str_mv 2005-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000600002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000600002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2005000600002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.63 n.4 2005
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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