Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000200017 |
Resumo: | A 21 year old male ingested podophyllin in a suicide attempt. The disorder was marked by seizures, coma, peripheral neuropathy, renal failure and acute necrotizing myopathy, an unusual finding. The coma and systemic disturbances resolved within three weeks. The myopathy resolved in 7 weeks, demonstrating a high capacity of muscle recuperation. The sensorimotor peripheral neuropathy persisted until the patient's death 9 weeks after the ingestion, due to septicemia. This report confirms the transient central neurotoxicity of podophyllin and persistent peripheral neurotoxicity of podophyllin, and describes a reversible necrotizing myopathy associated to mitochondrial abnormalities, a still unreported feature of podophyllin toxicity. |
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Acute necrotizing myopathy and podophyllin toxicity: report of a fatal casepodophyllinacute toxicitymyopathyA 21 year old male ingested podophyllin in a suicide attempt. The disorder was marked by seizures, coma, peripheral neuropathy, renal failure and acute necrotizing myopathy, an unusual finding. The coma and systemic disturbances resolved within three weeks. The myopathy resolved in 7 weeks, demonstrating a high capacity of muscle recuperation. The sensorimotor peripheral neuropathy persisted until the patient's death 9 weeks after the ingestion, due to septicemia. This report confirms the transient central neurotoxicity of podophyllin and persistent peripheral neurotoxicity of podophyllin, and describes a reversible necrotizing myopathy associated to mitochondrial abnormalities, a still unreported feature of podophyllin toxicity.Academia Brasileira de Neurologia - ABNEURO1996-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000200017Arquivos de Neuro-Psiquiatria v.54 n.2 1996reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X1996000200017info:eu-repo/semantics/openAccessOliveira,Acary Souza BulleCalia,Leandro CortoniKiyomoto,Beatriz HitomiPóvoa,Eliane FocacciaSchmidt,BenyGabbai,Alberto Alaineng2010-12-06T00:00:00Zoai:scielo:S0004-282X1996000200017Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-12-06T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case |
title |
Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case |
spellingShingle |
Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case Oliveira,Acary Souza Bulle podophyllin acute toxicity myopathy |
title_short |
Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case |
title_full |
Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case |
title_fullStr |
Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case |
title_full_unstemmed |
Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case |
title_sort |
Acute necrotizing myopathy and podophyllin toxicity: report of a fatal case |
author |
Oliveira,Acary Souza Bulle |
author_facet |
Oliveira,Acary Souza Bulle Calia,Leandro Cortoni Kiyomoto,Beatriz Hitomi Póvoa,Eliane Focaccia Schmidt,Beny Gabbai,Alberto Alain |
author_role |
author |
author2 |
Calia,Leandro Cortoni Kiyomoto,Beatriz Hitomi Póvoa,Eliane Focaccia Schmidt,Beny Gabbai,Alberto Alain |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Acary Souza Bulle Calia,Leandro Cortoni Kiyomoto,Beatriz Hitomi Póvoa,Eliane Focaccia Schmidt,Beny Gabbai,Alberto Alain |
dc.subject.por.fl_str_mv |
podophyllin acute toxicity myopathy |
topic |
podophyllin acute toxicity myopathy |
description |
A 21 year old male ingested podophyllin in a suicide attempt. The disorder was marked by seizures, coma, peripheral neuropathy, renal failure and acute necrotizing myopathy, an unusual finding. The coma and systemic disturbances resolved within three weeks. The myopathy resolved in 7 weeks, demonstrating a high capacity of muscle recuperation. The sensorimotor peripheral neuropathy persisted until the patient's death 9 weeks after the ingestion, due to septicemia. This report confirms the transient central neurotoxicity of podophyllin and persistent peripheral neurotoxicity of podophyllin, and describes a reversible necrotizing myopathy associated to mitochondrial abnormalities, a still unreported feature of podophyllin toxicity. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000200017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000200017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X1996000200017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.54 n.2 1996 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212749867483136 |