Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027 |
Resumo: | The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case. |
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Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case reportmyopathyhypothyroidismpseudohypertrophyThe frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case.Academia Brasileira de Neurologia - ABNEURO2003-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027Arquivos de Neuro-Psiquiatria v.61 n.3B 2003reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2003000500027info:eu-repo/semantics/openAccessVasconcellos,Luiz Felipe RochaPeixoto,Maria ClaudiaOliveira,Tatiana Nunes dePenque,GlóriaLeite,Ana Claudia Celestinoeng2003-11-12T00:00:00Zoai:scielo:S0004-282X2003000500027Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2003-11-12T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
title |
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
spellingShingle |
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report Vasconcellos,Luiz Felipe Rocha myopathy hypothyroidism pseudohypertrophy |
title_short |
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
title_full |
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
title_fullStr |
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
title_full_unstemmed |
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
title_sort |
Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report |
author |
Vasconcellos,Luiz Felipe Rocha |
author_facet |
Vasconcellos,Luiz Felipe Rocha Peixoto,Maria Claudia Oliveira,Tatiana Nunes de Penque,Glória Leite,Ana Claudia Celestino |
author_role |
author |
author2 |
Peixoto,Maria Claudia Oliveira,Tatiana Nunes de Penque,Glória Leite,Ana Claudia Celestino |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vasconcellos,Luiz Felipe Rocha Peixoto,Maria Claudia Oliveira,Tatiana Nunes de Penque,Glória Leite,Ana Claudia Celestino |
dc.subject.por.fl_str_mv |
myopathy hypothyroidism pseudohypertrophy |
topic |
myopathy hypothyroidism pseudohypertrophy |
description |
The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2003000500027 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.61 n.3B 2003 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212756114898944 |