Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report

Detalhes bibliográficos
Autor(a) principal: Vasconcellos,Luiz Felipe Rocha
Data de Publicação: 2003
Outros Autores: Peixoto,Maria Claudia, Oliveira,Tatiana Nunes de, Penque,Glória, Leite,Ana Claudia Celestino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027
Resumo: The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case.
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spelling Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case reportmyopathyhypothyroidismpseudohypertrophyThe frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case.Academia Brasileira de Neurologia - ABNEURO2003-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027Arquivos de Neuro-Psiquiatria v.61 n.3B 2003reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2003000500027info:eu-repo/semantics/openAccessVasconcellos,Luiz Felipe RochaPeixoto,Maria ClaudiaOliveira,Tatiana Nunes dePenque,GlóriaLeite,Ana Claudia Celestinoeng2003-11-12T00:00:00Zoai:scielo:S0004-282X2003000500027Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2003-11-12T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
title Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
spellingShingle Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
Vasconcellos,Luiz Felipe Rocha
myopathy
hypothyroidism
pseudohypertrophy
title_short Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
title_full Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
title_fullStr Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
title_full_unstemmed Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
title_sort Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
author Vasconcellos,Luiz Felipe Rocha
author_facet Vasconcellos,Luiz Felipe Rocha
Peixoto,Maria Claudia
Oliveira,Tatiana Nunes de
Penque,Glória
Leite,Ana Claudia Celestino
author_role author
author2 Peixoto,Maria Claudia
Oliveira,Tatiana Nunes de
Penque,Glória
Leite,Ana Claudia Celestino
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vasconcellos,Luiz Felipe Rocha
Peixoto,Maria Claudia
Oliveira,Tatiana Nunes de
Penque,Glória
Leite,Ana Claudia Celestino
dc.subject.por.fl_str_mv myopathy
hypothyroidism
pseudohypertrophy
topic myopathy
hypothyroidism
pseudohypertrophy
description The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case.
publishDate 2003
dc.date.none.fl_str_mv 2003-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500027
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2003000500027
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.61 n.3B 2003
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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