Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000100022 |
Resumo: | ABSTRACT Objectives To describe anticoagulation characteristics in patients with cardiac complications from Chagas disease and compare participants with and without cardioembolic ischemic stroke (CIS). Methods A retrospective cohort of patients with Chagas disease, using anticoagulation, conducted from January 2011 to December 2014. Results Forty-two patients with Chagas disease who were using anticoagulation were studied (age 62.9±12.4 years), 59.5% female and 47.6% with previous CIS, 78.6% with non-valvular atrial fibrillation and 69.7% with dilated cardiomyopathy. Warfarin was used in 78.6% of patients and dabigatran (at different times) in 38%. In the warfarin group, those with CIS had more medical appointments per person-years of follow-up (11.7 vs 7.9), a higher proportion of international normalized ratios within the therapeutic range (57% vs 42% medical appointments, p = 0.025) and an eight times higher frequency of minor bleeding (0.64 vs 0.07 medical appointments). Conclusion Patients with Chagas disease and previous CIS had better control of INR with a higher frequency of minor bleeding. |
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Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic strokeChagas diseasewarfarinstrokeatrial fibrillationABSTRACT Objectives To describe anticoagulation characteristics in patients with cardiac complications from Chagas disease and compare participants with and without cardioembolic ischemic stroke (CIS). Methods A retrospective cohort of patients with Chagas disease, using anticoagulation, conducted from January 2011 to December 2014. Results Forty-two patients with Chagas disease who were using anticoagulation were studied (age 62.9±12.4 years), 59.5% female and 47.6% with previous CIS, 78.6% with non-valvular atrial fibrillation and 69.7% with dilated cardiomyopathy. Warfarin was used in 78.6% of patients and dabigatran (at different times) in 38%. In the warfarin group, those with CIS had more medical appointments per person-years of follow-up (11.7 vs 7.9), a higher proportion of international normalized ratios within the therapeutic range (57% vs 42% medical appointments, p = 0.025) and an eight times higher frequency of minor bleeding (0.64 vs 0.07 medical appointments). Conclusion Patients with Chagas disease and previous CIS had better control of INR with a higher frequency of minor bleeding.Academia Brasileira de Neurologia - ABNEURO2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000100022Arquivos de Neuro-Psiquiatria v.76 n.1 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20170180info:eu-repo/semantics/openAccessMonteiro,Jean M.C.San-Martin,Daniel L.Silva,Beatriz C.G.Jesus,Pedro A.P. deOliveira Filho,Jamaryeng2018-01-17T00:00:00Zoai:scielo:S0004-282X2018000100022Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-01-17T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke |
title |
Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke |
spellingShingle |
Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke Monteiro,Jean M.C. Chagas disease warfarin stroke atrial fibrillation |
title_short |
Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke |
title_full |
Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke |
title_fullStr |
Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke |
title_full_unstemmed |
Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke |
title_sort |
Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke |
author |
Monteiro,Jean M.C. |
author_facet |
Monteiro,Jean M.C. San-Martin,Daniel L. Silva,Beatriz C.G. Jesus,Pedro A.P. de Oliveira Filho,Jamary |
author_role |
author |
author2 |
San-Martin,Daniel L. Silva,Beatriz C.G. Jesus,Pedro A.P. de Oliveira Filho,Jamary |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Monteiro,Jean M.C. San-Martin,Daniel L. Silva,Beatriz C.G. Jesus,Pedro A.P. de Oliveira Filho,Jamary |
dc.subject.por.fl_str_mv |
Chagas disease warfarin stroke atrial fibrillation |
topic |
Chagas disease warfarin stroke atrial fibrillation |
description |
ABSTRACT Objectives To describe anticoagulation characteristics in patients with cardiac complications from Chagas disease and compare participants with and without cardioembolic ischemic stroke (CIS). Methods A retrospective cohort of patients with Chagas disease, using anticoagulation, conducted from January 2011 to December 2014. Results Forty-two patients with Chagas disease who were using anticoagulation were studied (age 62.9±12.4 years), 59.5% female and 47.6% with previous CIS, 78.6% with non-valvular atrial fibrillation and 69.7% with dilated cardiomyopathy. Warfarin was used in 78.6% of patients and dabigatran (at different times) in 38%. In the warfarin group, those with CIS had more medical appointments per person-years of follow-up (11.7 vs 7.9), a higher proportion of international normalized ratios within the therapeutic range (57% vs 42% medical appointments, p = 0.025) and an eight times higher frequency of minor bleeding (0.64 vs 0.07 medical appointments). Conclusion Patients with Chagas disease and previous CIS had better control of INR with a higher frequency of minor bleeding. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000100022 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000100022 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20170180 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.76 n.1 2018 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
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