Update on biomarkers associated to cardioembolic stroke: a narrative review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/49057 |
Resumo: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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Update on biomarkers associated to cardioembolic stroke: a narrative reviewBiomarkerCardioembolismStrokeAtrial fibrillationPatent foramen ovaleAtrial cardiomyopathyNT-proBNPBNPANP© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Background: In the last years, several studies were conducted that evaluated biomarkers that could be helpful for cardioembolic stroke diagnosis, prognosis, and the determination of risk of stroke recurrence. Methods: We performed a narrative review of the main studies that evaluated biomarkers related to specific cardioembolic causes: atrial fibrillation, patent foramen ovale, atrial cardiomyopathy, and left ventricular wall motion abnormalities. Results: BNP and NT-proBNP are, among all biomarkers of cardioembolic stroke, the ones that have the highest amount of evidence for their use. NT-proBNP is currently used for the selection of patients that will be included in clinical trials that aim to evaluate the use of anticoagulation in patients suspected of having a cardioembolic stroke and for the selection of patients to undergo cardiac monitoring. NT-proBNP has also been incorporated in tools used to predict the risk of stroke recurrence (ABC-stroke score). Conclusions: NT-proBNP and BNP continue to be the biomarkers most widely studied in the context of cardioembolic stroke. The possibility of using other biomarkers in clinical practice is still distant, mainly because of the low methodological quality of the studies in which they were evaluated. Both internal and external validation studies are rarely performed for most biomarkers.MDPIRepositório da Universidade de LisboaFonseca, Ana CatarinaCoelho, Pedro2021-07-22T13:10:19Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49057engLife (Basel). 2021 May 17;11(5):448.10.3390/life110504482075-1729info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:20Zoai:repositorio.ul.pt:10451/49057Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:36.275305Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Update on biomarkers associated to cardioembolic stroke: a narrative review |
title |
Update on biomarkers associated to cardioembolic stroke: a narrative review |
spellingShingle |
Update on biomarkers associated to cardioembolic stroke: a narrative review Fonseca, Ana Catarina Biomarker Cardioembolism Stroke Atrial fibrillation Patent foramen ovale Atrial cardiomyopathy NT-proBNP BNP ANP |
title_short |
Update on biomarkers associated to cardioembolic stroke: a narrative review |
title_full |
Update on biomarkers associated to cardioembolic stroke: a narrative review |
title_fullStr |
Update on biomarkers associated to cardioembolic stroke: a narrative review |
title_full_unstemmed |
Update on biomarkers associated to cardioembolic stroke: a narrative review |
title_sort |
Update on biomarkers associated to cardioembolic stroke: a narrative review |
author |
Fonseca, Ana Catarina |
author_facet |
Fonseca, Ana Catarina Coelho, Pedro |
author_role |
author |
author2 |
Coelho, Pedro |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Fonseca, Ana Catarina Coelho, Pedro |
dc.subject.por.fl_str_mv |
Biomarker Cardioembolism Stroke Atrial fibrillation Patent foramen ovale Atrial cardiomyopathy NT-proBNP BNP ANP |
topic |
Biomarker Cardioembolism Stroke Atrial fibrillation Patent foramen ovale Atrial cardiomyopathy NT-proBNP BNP ANP |
description |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-22T13:10:19Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/49057 |
url |
http://hdl.handle.net/10451/49057 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life (Basel). 2021 May 17;11(5):448. 10.3390/life11050448 2075-1729 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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