Gut microbiome in neuropsychiatric disorders
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000200192 |
Resumo: | ABSTRACT Background: Neuropsychiatric disorders are a significant cause of death and disability worldwide. The mechanisms underlying these disorders include a constellation of structural, infectious, immunological, metabolic, and genetic etiologies. Advances in next-generation sequencing techniques have demonstrated that the composition of the enteric microbiome is dynamic and plays a pivotal role in host homeostasis and several diseases. The enteric microbiome acts as a key mediator in neuronal signaling via metabolic, neuroimmune, and neuroendocrine pathways. Objective: In this review, we aim to present and discuss the most current knowledge regarding the putative influence of the gut microbiome in neuropsychiatric disorders. Methods: We examined some of the preclinical and clinical evidence and therapeutic strategies associated with the manipulation of the gut microbiome. Results: targeted taxa were described and grouped from major studies to each disease. Conclusions: Understanding the complexity of these ecological interactions and their association with susceptibility and progression of acute and chronic disorders could lead to novel diagnostic biomarkers based on molecular targets. Moreover, research on the microbiome can also improve some emerging treatment choices, such as fecal transplantation, personalized probiotics, and dietary interventions, which could be used to reduce the impact of specific neuropsychiatric disorders. We expect that this knowledge will help physicians caring for patients with neuropsychiatric disorders. |
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Gut microbiome in neuropsychiatric disordersGastrointestinal MicrobiomeMetagenomicsNervous System DiseasesTransplantationPrecision MedicineABSTRACT Background: Neuropsychiatric disorders are a significant cause of death and disability worldwide. The mechanisms underlying these disorders include a constellation of structural, infectious, immunological, metabolic, and genetic etiologies. Advances in next-generation sequencing techniques have demonstrated that the composition of the enteric microbiome is dynamic and plays a pivotal role in host homeostasis and several diseases. The enteric microbiome acts as a key mediator in neuronal signaling via metabolic, neuroimmune, and neuroendocrine pathways. Objective: In this review, we aim to present and discuss the most current knowledge regarding the putative influence of the gut microbiome in neuropsychiatric disorders. Methods: We examined some of the preclinical and clinical evidence and therapeutic strategies associated with the manipulation of the gut microbiome. Results: targeted taxa were described and grouped from major studies to each disease. Conclusions: Understanding the complexity of these ecological interactions and their association with susceptibility and progression of acute and chronic disorders could lead to novel diagnostic biomarkers based on molecular targets. Moreover, research on the microbiome can also improve some emerging treatment choices, such as fecal transplantation, personalized probiotics, and dietary interventions, which could be used to reduce the impact of specific neuropsychiatric disorders. We expect that this knowledge will help physicians caring for patients with neuropsychiatric disorders.Academia Brasileira de Neurologia - ABNEURO2022-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000200192Arquivos de Neuro-Psiquiatria v.80 n.2 2022reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x-anp-2021-0052info:eu-repo/semantics/openAccessMEJÍA-GRANADOS,Diana MarcelaVILLASANA-SALAZAR,BenjamínCOAN,Ana CarolinaRIZZI,LiaraBALTHAZAR,Marcio Luiz FigueredoGODOI,Alexandre Barcia deCANTO,Amanda Morato doROSA,Douglas Cescon daSILVA,Lucas ScárduaTACLA,Rafaella do RosarioDAMASCENO,AlfredoDONATTI,AmandaAVELAR,Wagner MauadSOUSA,AlessandroLOPES-CENDES,Isciaeng2022-03-22T00:00:00Zoai:scielo:S0004-282X2022000200192Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2022-03-22T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Gut microbiome in neuropsychiatric disorders |
title |
Gut microbiome in neuropsychiatric disorders |
spellingShingle |
Gut microbiome in neuropsychiatric disorders MEJÍA-GRANADOS,Diana Marcela Gastrointestinal Microbiome Metagenomics Nervous System Diseases Transplantation Precision Medicine |
title_short |
Gut microbiome in neuropsychiatric disorders |
title_full |
Gut microbiome in neuropsychiatric disorders |
title_fullStr |
Gut microbiome in neuropsychiatric disorders |
title_full_unstemmed |
Gut microbiome in neuropsychiatric disorders |
title_sort |
Gut microbiome in neuropsychiatric disorders |
author |
MEJÍA-GRANADOS,Diana Marcela |
author_facet |
MEJÍA-GRANADOS,Diana Marcela VILLASANA-SALAZAR,Benjamín COAN,Ana Carolina RIZZI,Liara BALTHAZAR,Marcio Luiz Figueredo GODOI,Alexandre Barcia de CANTO,Amanda Morato do ROSA,Douglas Cescon da SILVA,Lucas Scárdua TACLA,Rafaella do Rosario DAMASCENO,Alfredo DONATTI,Amanda AVELAR,Wagner Mauad SOUSA,Alessandro LOPES-CENDES,Iscia |
author_role |
author |
author2 |
VILLASANA-SALAZAR,Benjamín COAN,Ana Carolina RIZZI,Liara BALTHAZAR,Marcio Luiz Figueredo GODOI,Alexandre Barcia de CANTO,Amanda Morato do ROSA,Douglas Cescon da SILVA,Lucas Scárdua TACLA,Rafaella do Rosario DAMASCENO,Alfredo DONATTI,Amanda AVELAR,Wagner Mauad SOUSA,Alessandro LOPES-CENDES,Iscia |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
MEJÍA-GRANADOS,Diana Marcela VILLASANA-SALAZAR,Benjamín COAN,Ana Carolina RIZZI,Liara BALTHAZAR,Marcio Luiz Figueredo GODOI,Alexandre Barcia de CANTO,Amanda Morato do ROSA,Douglas Cescon da SILVA,Lucas Scárdua TACLA,Rafaella do Rosario DAMASCENO,Alfredo DONATTI,Amanda AVELAR,Wagner Mauad SOUSA,Alessandro LOPES-CENDES,Iscia |
dc.subject.por.fl_str_mv |
Gastrointestinal Microbiome Metagenomics Nervous System Diseases Transplantation Precision Medicine |
topic |
Gastrointestinal Microbiome Metagenomics Nervous System Diseases Transplantation Precision Medicine |
description |
ABSTRACT Background: Neuropsychiatric disorders are a significant cause of death and disability worldwide. The mechanisms underlying these disorders include a constellation of structural, infectious, immunological, metabolic, and genetic etiologies. Advances in next-generation sequencing techniques have demonstrated that the composition of the enteric microbiome is dynamic and plays a pivotal role in host homeostasis and several diseases. The enteric microbiome acts as a key mediator in neuronal signaling via metabolic, neuroimmune, and neuroendocrine pathways. Objective: In this review, we aim to present and discuss the most current knowledge regarding the putative influence of the gut microbiome in neuropsychiatric disorders. Methods: We examined some of the preclinical and clinical evidence and therapeutic strategies associated with the manipulation of the gut microbiome. Results: targeted taxa were described and grouped from major studies to each disease. Conclusions: Understanding the complexity of these ecological interactions and their association with susceptibility and progression of acute and chronic disorders could lead to novel diagnostic biomarkers based on molecular targets. Moreover, research on the microbiome can also improve some emerging treatment choices, such as fecal transplantation, personalized probiotics, and dietary interventions, which could be used to reduce the impact of specific neuropsychiatric disorders. We expect that this knowledge will help physicians caring for patients with neuropsychiatric disorders. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000200192 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000200192 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x-anp-2021-0052 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.80 n.2 2022 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
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