Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Odontologia |
Texto Completo: | https://revista.aborj.org.br/index.php/rbo/article/view/803 |
Resumo: | Objective: the objective of this study was to carry out histomorphometric analysis on the combination of rifamycin SV monosodium salt with synthetic hydroxyapatite for bone repair in rabbit tibiae. Material and Methods: twelve male white rabbits were equally divided into test group and control group. Drill hole defects were created in the tibia of the animals and were filled with either synthetic hydroxyapatite and physiological solution (control group) or with the combination of synthetic hydroxyapatite and rifamycin SV monosodium salt (test group). Moreover, all defects were covered by expanded polytetrafluoroethylene barriers. The animals were euthanized at 7, 14, or 21 days. The tissue sections were mounted onto slides (hematoxylin and eosin stains) and were analyzed using an optical microscope. Results: the tested association presented better microbiological local control, faster bone matrix deposition rate, and higher final total amount of bone matrix deposition. Conclusion: the combination of rifamycin with synthetic hydroxyapatite seems to be advantageous under the tested conditions, encouraging the development of new animal model studies. |
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Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot studyAvaliação histomorfométrica da combinação de rifamicina com hidroxiapatita sintética na reparação óssea em tíbia de coelhos: um estudo pilotoMEDICINA DENTÁRIA (ODONTOLOGIA)Tecido ósseo; Hidroxiapatita; AntibacterianosDENTAL MEDICINE (DENTISTRY)Bone tissue; Hydroxyapatite; AntibacterialsObjective: the objective of this study was to carry out histomorphometric analysis on the combination of rifamycin SV monosodium salt with synthetic hydroxyapatite for bone repair in rabbit tibiae. Material and Methods: twelve male white rabbits were equally divided into test group and control group. Drill hole defects were created in the tibia of the animals and were filled with either synthetic hydroxyapatite and physiological solution (control group) or with the combination of synthetic hydroxyapatite and rifamycin SV monosodium salt (test group). Moreover, all defects were covered by expanded polytetrafluoroethylene barriers. The animals were euthanized at 7, 14, or 21 days. The tissue sections were mounted onto slides (hematoxylin and eosin stains) and were analyzed using an optical microscope. Results: the tested association presented better microbiological local control, faster bone matrix deposition rate, and higher final total amount of bone matrix deposition. Conclusion: the combination of rifamycin with synthetic hydroxyapatite seems to be advantageous under the tested conditions, encouraging the development of new animal model studies.Objetivo: realizar avaliação histomorfométrica da associação do antibiótico rifamicina SV sódica à hidroxiapatita sintética na reparação óssea em tíbia de coelhos. Material e Métodos: doze coelhos brancos machos foram igualmente divididos em Grupo Teste e Controle. Lojas ósseas foram criadas nas tíbias dos animais e preenchidas com hidroxiapatita sintética e solução fisiológica (Grupo Controle) ou associação de hidroxiapatita sintética e rifamicina SV sal sódico (Grupo Teste). Além do mais, sobre todas as perfurações foram fixadas barreiras de politetrafluoretileno expandido. Os animais foram sacrificados após 7, 14 ou 21 dias da cirurgia, lâminas para análise em microscópio óptico foram preparadas (coloração H&E) e as análises realizadas. Resultados: a associação testada demonstrou superioridade no controle microbiológico local, na velocidade de formação e na quantidade final total de deposição de matriz óssea. Conclusão: a combinação de rifamicina com hidroxiapatita sintética parece apresentar vantagens nas condições testadas, incentivando a realização de novos estudos em modelo animal.Associação Brasileira de Odontologia - Seção Rio de JaneiroPalma, Luiz FelipePaiva, Thalita CaetanoSato, Nelson MasanobuFrigo, LúcioKfouri, Flávio de Ávila2017-06-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionOriginal articleArtigo originalapplication/pdfhttps://revista.aborj.org.br/index.php/rbo/article/view/80310.18363/rbo.v74n2.p.82Revista Brasileira de Odontologia; v. 74, n. 2 (2017); 82Revista Brasileira de Odontologia; v. 74, n. 2 (2017); 821984-3747reponame:Revista Brasileira de Odontologiainstname:Associação Brasileira de Odontologia (ABO)instacron:ABOporhttps://revista.aborj.org.br/index.php/rbo/article/view/803/610https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/680https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/681https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/682https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/683https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/684https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/685https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/686https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/687Mogi das Cruzes; Brasil; América LatinaMogi das Cruzes; Brazil; Latin AmericaDireitos autorais 2017 Rev. Bras. Odontol.http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess2019-01-23T13:23:56Zoai:revista_aborj_org_br.www.revista.aborj.org.br:article/803Revistahttps://revista.aborj.org.br/index.php/rboONGhttp://www.revista.aborj.org.br/index.php/rbo/oaihttps://revista.aborj.org.br/index.php/rbo/oai0034-72721984-3747opendoar:2019-01-23T13:23:56Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO)false |
dc.title.none.fl_str_mv |
Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study Avaliação histomorfométrica da combinação de rifamicina com hidroxiapatita sintética na reparação óssea em tíbia de coelhos: um estudo piloto |
title |
Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study |
spellingShingle |
Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study Palma, Luiz Felipe MEDICINA DENTÁRIA (ODONTOLOGIA) Tecido ósseo; Hidroxiapatita; Antibacterianos DENTAL MEDICINE (DENTISTRY) Bone tissue; Hydroxyapatite; Antibacterials |
title_short |
Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study |
title_full |
Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study |
title_fullStr |
Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study |
title_full_unstemmed |
Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study |
title_sort |
Histomorphometric evaluation of rifamycin combined with synthetic hydroxyapatite on bone healing in rabbit tibiae: a pilot study |
author |
Palma, Luiz Felipe |
author_facet |
Palma, Luiz Felipe Paiva, Thalita Caetano Sato, Nelson Masanobu Frigo, Lúcio Kfouri, Flávio de Ávila |
author_role |
author |
author2 |
Paiva, Thalita Caetano Sato, Nelson Masanobu Frigo, Lúcio Kfouri, Flávio de Ávila |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
|
dc.contributor.author.fl_str_mv |
Palma, Luiz Felipe Paiva, Thalita Caetano Sato, Nelson Masanobu Frigo, Lúcio Kfouri, Flávio de Ávila |
dc.subject.none.fl_str_mv |
|
dc.subject.por.fl_str_mv |
MEDICINA DENTÁRIA (ODONTOLOGIA) Tecido ósseo; Hidroxiapatita; Antibacterianos DENTAL MEDICINE (DENTISTRY) Bone tissue; Hydroxyapatite; Antibacterials |
topic |
MEDICINA DENTÁRIA (ODONTOLOGIA) Tecido ósseo; Hidroxiapatita; Antibacterianos DENTAL MEDICINE (DENTISTRY) Bone tissue; Hydroxyapatite; Antibacterials |
description |
Objective: the objective of this study was to carry out histomorphometric analysis on the combination of rifamycin SV monosodium salt with synthetic hydroxyapatite for bone repair in rabbit tibiae. Material and Methods: twelve male white rabbits were equally divided into test group and control group. Drill hole defects were created in the tibia of the animals and were filled with either synthetic hydroxyapatite and physiological solution (control group) or with the combination of synthetic hydroxyapatite and rifamycin SV monosodium salt (test group). Moreover, all defects were covered by expanded polytetrafluoroethylene barriers. The animals were euthanized at 7, 14, or 21 days. The tissue sections were mounted onto slides (hematoxylin and eosin stains) and were analyzed using an optical microscope. Results: the tested association presented better microbiological local control, faster bone matrix deposition rate, and higher final total amount of bone matrix deposition. Conclusion: the combination of rifamycin with synthetic hydroxyapatite seems to be advantageous under the tested conditions, encouraging the development of new animal model studies. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-29 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Original article Artigo original |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/803 10.18363/rbo.v74n2.p.82 |
url |
https://revista.aborj.org.br/index.php/rbo/article/view/803 |
identifier_str_mv |
10.18363/rbo.v74n2.p.82 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/803/610 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/680 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/681 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/682 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/683 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/684 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/685 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/686 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/803/687 |
dc.rights.driver.fl_str_mv |
Direitos autorais 2017 Rev. Bras. Odontol. http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos autorais 2017 Rev. Bras. Odontol. http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Mogi das Cruzes; Brasil; América Latina Mogi das Cruzes; Brazil; Latin America |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
dc.source.none.fl_str_mv |
Revista Brasileira de Odontologia; v. 74, n. 2 (2017); 82 Revista Brasileira de Odontologia; v. 74, n. 2 (2017); 82 1984-3747 reponame:Revista Brasileira de Odontologia instname:Associação Brasileira de Odontologia (ABO) instacron:ABO |
instname_str |
Associação Brasileira de Odontologia (ABO) |
instacron_str |
ABO |
institution |
ABO |
reponame_str |
Revista Brasileira de Odontologia |
collection |
Revista Brasileira de Odontologia |
repository.name.fl_str_mv |
Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO) |
repository.mail.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/oai |
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1798313200655007744 |