Oral manifestations of chronic graft vs host disease: systematic literature review

• Autor(a) principal: Soares, Álvaro Cavalheiro
• Data de Publicação: 2016
• Outros Autores: Alencar, Felipe Souza Lima, Antunes, Héliton Spindola
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Brasileira de Odontologia
• Texto Completo: https://revista.aborj.org.br/index.php/rbo/article/view/674
• topic: DENTAL MEDICINE ( DENTISTRY ); Stem cell transplantation; Graft vs host disease; Lichenoid eruptions; Ulcer; Xerostomia.; MEDICINA DENTÁRIA (ODONTOLOGIA); Transplante de células-tronco; Doença enxerto-hospedeiro, erupções liquenoides; Úlcera; Xenostomia; Manifestações bucais, Odontologia

Objective: To identify the frequency of oral manifestations of cGVHD in patients undergoing HSCT, through a systematic review of the literature. Material and Methods: It was performed a systematic review of the literature using the databases PubMed, Cochrane and Dentistry & Oral Sciences Source to perform the literature search (september/2015), which resulted in a total of 212 publications, among which 40 were included in the study. Results: The lichenoid lesions were reported in 82.5% of the studies, the most frequent changes among many others found, such as ulcers, reported in 57,1% of the studies, mucosal atrophy in 45,7%, mucocele in 37,1% pseudomembranes in 17.1%. Among the symptoms, dry mouth was reported in 80% of studies, overcoming the pain (48,5%), sensitivity/burning (34,2%) dysgeusia/ageusia (17,1%), dysphagia (14,2%), among others. Conclusion: There was, in the literature, a high occurrence of various oral manifestations associated with cGVHD.