Treatment of oral manifestations of chronic graft versus host disease: systematic literature review
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Odontologia |
Texto Completo: | https://revista.aborj.org.br/index.php/rbo/article/view/675 |
Resumo: | Objective: To summarize the main therapeutic modalities used in the treatment of oral manifestations of graft versus host disease (GVHD), through a systematic review of the literature. Material and Methods: A search was conducted in the databases Cochrane Library, Dentistry & Oral Sciences and Pubmed, with descriptors for the treatment of chronic GVHD with oral involvement, between June and October 2015. The methodology was defined from reading the titles, abstracts and articles available. Results: Founded 32 publications that presented a total of 13 immunosuppressant drugs, and 07 which were employed by local therapy and systemically 06. Two articles treated auxiliary therapies to relieve hyposalivation. Conclusion: Drugs found may serve as parameters for future drugs to be used in clinical practice. The treatment of oral GVHD still has limited effectiveness, however, suggests the use of topical medications to reduce systemic effects. Prospective studies are needed, randomized controlled trials to prove the effectiveness of these medications. |
id |
ABO-1_ab05a977cd58d9c60b841f2556ab68fd |
---|---|
oai_identifier_str |
oai:revista_aborj_org_br.www.revista.aborj.org.br:article/675 |
network_acronym_str |
ABO-1 |
network_name_str |
Revista Brasileira de Odontologia |
repository_id_str |
|
spelling |
Treatment of oral manifestations of chronic graft versus host disease: systematic literature reviewTratamento das manifestações orais da doença enxerto contra o hospedeiro crônica: revisão sistêmica da literaturaDENTAL MEDICINE ( DENTISTRY )Therapy; Graft-versus-host disease; Immunosuppressants; Steroids; Oral manifestations.MEDICINA DENTÁRIA (ODONTOLOGIA)Terapia; Dença do enxerto-hospedeiro, imunossupressores; esteroides; Manifestações bucaisManifestações bucaisObjective: To summarize the main therapeutic modalities used in the treatment of oral manifestations of graft versus host disease (GVHD), through a systematic review of the literature. Material and Methods: A search was conducted in the databases Cochrane Library, Dentistry & Oral Sciences and Pubmed, with descriptors for the treatment of chronic GVHD with oral involvement, between June and October 2015. The methodology was defined from reading the titles, abstracts and articles available. Results: Founded 32 publications that presented a total of 13 immunosuppressant drugs, and 07 which were employed by local therapy and systemically 06. Two articles treated auxiliary therapies to relieve hyposalivation. Conclusion: Drugs found may serve as parameters for future drugs to be used in clinical practice. The treatment of oral GVHD still has limited effectiveness, however, suggests the use of topical medications to reduce systemic effects. Prospective studies are needed, randomized controlled trials to prove the effectiveness of these medications.A doença enxerto contra hospedeiro crônica (DECHc) pode acometer vários órgãos. Ela é a principal causa de perda de qualidade de vida de pacientes pós-transplantados e pode causar a morte desses pacientes. A cavidade oral é o segundo local mais prevalente, os principais objetivos do tratamento são aliviar os sintomas, manter as funções orais e restaurar a integridade da mucosa. OBJETIVO: Analisar os principais fármacos usados no tratamento das manifestações orais da DECHc, através de uma revisão sistemática da literatura. METODOLOGIA: Foi realizada uma busca nas bases de dados COCHRANE LIBRARY, DENTISTRY & ORAL SCIENCES e PUBMED, com descritores para o tratamento da DECHc com envolvimento oral. Definiu-se uma metodologia de seleção a partir da leitura dos títulos, resumos e artigos disponíveis. RESULTADOS: Foram encontradas 32 publicações, desses, 12 foram revisões de literatura. Dezoito tratavam sobre as terapias com resultados em cavidade oral. Um total de 13 fármacos foram encontrados, 07 dos quais foram empregados por meio de terapia local e 06 via sistêmica. Dois artigos tratavam de terapias auxiliares para o alívio da hipossalivação. CONCLUSÃO: As medicações encontradas podem servir de parâmetros para futuros fármacos a serem empregados na prática clínica. O tratamento da DECHc bucal ainda apresenta eficácia limitada, todavia sugere-se o uso de medicação tópica para reduzir efeitos sistêmicos. São necessários estudos prospectivos, randomizados e controlados para comprovar a eficácia de certas medicações.Associação Brasileira de Odontologia - Seção Rio de JaneiroAlencar, Felipe Souza LimaSoares, Álvaro CavalheiroAntunes, Héliton Spíndola2016-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de Literaturaapplication/pdfhttps://revista.aborj.org.br/index.php/rbo/article/view/67510.18363/rbo.v73n2.p.165Revista Brasileira de Odontologia; v. 73, n. 2 (2016); 165Revista Brasileira de Odontologia; v. 73, n. 2 (2016); 1651984-3747reponame:Revista Brasileira de Odontologiainstname:Associação Brasileira de Odontologia (ABO)instacron:ABOporhttps://revista.aborj.org.br/index.php/rbo/article/view/675/522Direitos autorais 2016 Revistasinfo:eu-repo/semantics/openAccess2016-07-11T12:16:16Zoai:revista_aborj_org_br.www.revista.aborj.org.br:article/675Revistahttps://revista.aborj.org.br/index.php/rboONGhttp://www.revista.aborj.org.br/index.php/rbo/oaihttps://revista.aborj.org.br/index.php/rbo/oai0034-72721984-3747opendoar:2016-07-11T12:16:16Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO)false |
dc.title.none.fl_str_mv |
Treatment of oral manifestations of chronic graft versus host disease: systematic literature review Tratamento das manifestações orais da doença enxerto contra o hospedeiro crônica: revisão sistêmica da literatura |
title |
Treatment of oral manifestations of chronic graft versus host disease: systematic literature review |
spellingShingle |
Treatment of oral manifestations of chronic graft versus host disease: systematic literature review Alencar, Felipe Souza Lima DENTAL MEDICINE ( DENTISTRY ) Therapy; Graft-versus-host disease; Immunosuppressants; Steroids; Oral manifestations. MEDICINA DENTÁRIA (ODONTOLOGIA) Terapia; Dença do enxerto-hospedeiro, imunossupressores; esteroides; Manifestações bucais Manifestações bucais |
title_short |
Treatment of oral manifestations of chronic graft versus host disease: systematic literature review |
title_full |
Treatment of oral manifestations of chronic graft versus host disease: systematic literature review |
title_fullStr |
Treatment of oral manifestations of chronic graft versus host disease: systematic literature review |
title_full_unstemmed |
Treatment of oral manifestations of chronic graft versus host disease: systematic literature review |
title_sort |
Treatment of oral manifestations of chronic graft versus host disease: systematic literature review |
author |
Alencar, Felipe Souza Lima |
author_facet |
Alencar, Felipe Souza Lima Soares, Álvaro Cavalheiro Antunes, Héliton Spíndola |
author_role |
author |
author2 |
Soares, Álvaro Cavalheiro Antunes, Héliton Spíndola |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
|
dc.contributor.author.fl_str_mv |
Alencar, Felipe Souza Lima Soares, Álvaro Cavalheiro Antunes, Héliton Spíndola |
dc.subject.none.fl_str_mv |
|
dc.subject.por.fl_str_mv |
DENTAL MEDICINE ( DENTISTRY ) Therapy; Graft-versus-host disease; Immunosuppressants; Steroids; Oral manifestations. MEDICINA DENTÁRIA (ODONTOLOGIA) Terapia; Dença do enxerto-hospedeiro, imunossupressores; esteroides; Manifestações bucais Manifestações bucais |
topic |
DENTAL MEDICINE ( DENTISTRY ) Therapy; Graft-versus-host disease; Immunosuppressants; Steroids; Oral manifestations. MEDICINA DENTÁRIA (ODONTOLOGIA) Terapia; Dença do enxerto-hospedeiro, imunossupressores; esteroides; Manifestações bucais Manifestações bucais |
description |
Objective: To summarize the main therapeutic modalities used in the treatment of oral manifestations of graft versus host disease (GVHD), through a systematic review of the literature. Material and Methods: A search was conducted in the databases Cochrane Library, Dentistry & Oral Sciences and Pubmed, with descriptors for the treatment of chronic GVHD with oral involvement, between June and October 2015. The methodology was defined from reading the titles, abstracts and articles available. Results: Founded 32 publications that presented a total of 13 immunosuppressant drugs, and 07 which were employed by local therapy and systemically 06. Two articles treated auxiliary therapies to relieve hyposalivation. Conclusion: Drugs found may serve as parameters for future drugs to be used in clinical practice. The treatment of oral GVHD still has limited effectiveness, however, suggests the use of topical medications to reduce systemic effects. Prospective studies are needed, randomized controlled trials to prove the effectiveness of these medications. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-30 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Revisão de Literatura |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/675 10.18363/rbo.v73n2.p.165 |
url |
https://revista.aborj.org.br/index.php/rbo/article/view/675 |
identifier_str_mv |
10.18363/rbo.v73n2.p.165 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/675/522 |
dc.rights.driver.fl_str_mv |
Direitos autorais 2016 Revistas info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos autorais 2016 Revistas |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
|
dc.publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
dc.source.none.fl_str_mv |
Revista Brasileira de Odontologia; v. 73, n. 2 (2016); 165 Revista Brasileira de Odontologia; v. 73, n. 2 (2016); 165 1984-3747 reponame:Revista Brasileira de Odontologia instname:Associação Brasileira de Odontologia (ABO) instacron:ABO |
instname_str |
Associação Brasileira de Odontologia (ABO) |
instacron_str |
ABO |
institution |
ABO |
reponame_str |
Revista Brasileira de Odontologia |
collection |
Revista Brasileira de Odontologia |
repository.name.fl_str_mv |
Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO) |
repository.mail.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/oai |
_version_ |
1798313204937392128 |