Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation

Detalhes bibliográficos
Autor(a) principal: Jaafari-Ashkavandi,Zohreh
Data de Publicação: 2019
Outros Autores: Ashraf,Mohammad Javad, Abbaspoorfard,Ali Asghar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Otorhinolaryngology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942019000200144
Resumo: Abstract Introduction: Cell division cycle-7 protein is a serine/threonine kinase that has a basic role in cell cycle regulation and is a potential prognostic or therapeutic target in some human cancers. Objectives: This study investigated the expression of cell division cycle-7 protein in benign and malignant salivary gland tumors and also its correlation with clinicopathologic factors. Methods: Immunohistochemical expression of cell division cycle-7 was evaluated in 46 cases, including 15 adenoid cystic carcinoma, 12 mucoepidermoid carcinoma, 14 pleomorphic adenoma, and 5 normal salivary glands. Cell division cycle-7 expression rate and intensity were compared statistically. Results: The protein was expressed in almost all tumors. The intensity and mean of cell division cycle-7 expression were higher in malignant tumors in comparison with pleomorphic adenomas (p = 0.000). The protein expression was correlated with tumor grades (p = 0.000). Conclusions: The present study demonstrated cell division cycle-7 overexpression in malignant salivary gland tumors in comparison with pleomorphic adenomas, and also a correlation with tumor differentiation. Therefore, this protein might be a potential prognostic and therapeutic target for salivary gland tumors.
id ABORL-F-1_23844bfdd0df58d65ce2ab804980d43a
oai_identifier_str oai:scielo:S1808-86942019000200144
network_acronym_str ABORL-F-1
network_name_str Brazilian Journal of Otorhinolaryngology
repository_id_str
spelling Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiationSalivary glandCDC7Adenoid cystic carcinomaMucoepidermoid carcinomaPleomorphic adenomaAbstract Introduction: Cell division cycle-7 protein is a serine/threonine kinase that has a basic role in cell cycle regulation and is a potential prognostic or therapeutic target in some human cancers. Objectives: This study investigated the expression of cell division cycle-7 protein in benign and malignant salivary gland tumors and also its correlation with clinicopathologic factors. Methods: Immunohistochemical expression of cell division cycle-7 was evaluated in 46 cases, including 15 adenoid cystic carcinoma, 12 mucoepidermoid carcinoma, 14 pleomorphic adenoma, and 5 normal salivary glands. Cell division cycle-7 expression rate and intensity were compared statistically. Results: The protein was expressed in almost all tumors. The intensity and mean of cell division cycle-7 expression were higher in malignant tumors in comparison with pleomorphic adenomas (p = 0.000). The protein expression was correlated with tumor grades (p = 0.000). Conclusions: The present study demonstrated cell division cycle-7 overexpression in malignant salivary gland tumors in comparison with pleomorphic adenomas, and also a correlation with tumor differentiation. Therefore, this protein might be a potential prognostic and therapeutic target for salivary gland tumors.Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2019-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942019000200144Brazilian Journal of Otorhinolaryngology v.85 n.2 2019reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2017.11.004info:eu-repo/semantics/openAccessJaafari-Ashkavandi,ZohrehAshraf,Mohammad JavadAbbaspoorfard,Ali Asghareng2019-04-24T00:00:00Zoai:scielo:S1808-86942019000200144Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2019-04-24T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false
dc.title.none.fl_str_mv Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation
title Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation
spellingShingle Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation
Jaafari-Ashkavandi,Zohreh
Salivary gland
CDC7
Adenoid cystic carcinoma
Mucoepidermoid carcinoma
Pleomorphic adenoma
title_short Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation
title_full Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation
title_fullStr Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation
title_full_unstemmed Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation
title_sort Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation
author Jaafari-Ashkavandi,Zohreh
author_facet Jaafari-Ashkavandi,Zohreh
Ashraf,Mohammad Javad
Abbaspoorfard,Ali Asghar
author_role author
author2 Ashraf,Mohammad Javad
Abbaspoorfard,Ali Asghar
author2_role author
author
dc.contributor.author.fl_str_mv Jaafari-Ashkavandi,Zohreh
Ashraf,Mohammad Javad
Abbaspoorfard,Ali Asghar
dc.subject.por.fl_str_mv Salivary gland
CDC7
Adenoid cystic carcinoma
Mucoepidermoid carcinoma
Pleomorphic adenoma
topic Salivary gland
CDC7
Adenoid cystic carcinoma
Mucoepidermoid carcinoma
Pleomorphic adenoma
description Abstract Introduction: Cell division cycle-7 protein is a serine/threonine kinase that has a basic role in cell cycle regulation and is a potential prognostic or therapeutic target in some human cancers. Objectives: This study investigated the expression of cell division cycle-7 protein in benign and malignant salivary gland tumors and also its correlation with clinicopathologic factors. Methods: Immunohistochemical expression of cell division cycle-7 was evaluated in 46 cases, including 15 adenoid cystic carcinoma, 12 mucoepidermoid carcinoma, 14 pleomorphic adenoma, and 5 normal salivary glands. Cell division cycle-7 expression rate and intensity were compared statistically. Results: The protein was expressed in almost all tumors. The intensity and mean of cell division cycle-7 expression were higher in malignant tumors in comparison with pleomorphic adenomas (p = 0.000). The protein expression was correlated with tumor grades (p = 0.000). Conclusions: The present study demonstrated cell division cycle-7 overexpression in malignant salivary gland tumors in comparison with pleomorphic adenomas, and also a correlation with tumor differentiation. Therefore, this protein might be a potential prognostic and therapeutic target for salivary gland tumors.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942019000200144
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942019000200144
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjorl.2017.11.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
dc.source.none.fl_str_mv Brazilian Journal of Otorhinolaryngology v.85 n.2 2019
reponame:Brazilian Journal of Otorhinolaryngology
instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron:ABORL-CCF
instname_str Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron_str ABORL-CCF
institution ABORL-CCF
reponame_str Brazilian Journal of Otorhinolaryngology
collection Brazilian Journal of Otorhinolaryngology
repository.name.fl_str_mv Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
repository.mail.fl_str_mv revista@aborlccf.org.br||revista@aborlccf.org.br
_version_ 1754575993286164480

Registros relacionados