DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression

Detalhes bibliográficos
Autor(a) principal: Bernardes,Vanessa Fátima
Data de Publicação: 2017
Outros Autores: Odell,Edward W, Gomez,Ricardo Santiago, Gomes,Carolina Cavalieri
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000200148
Resumo: Chromosomal instability, leading to aneuploidy, is one of the hallmarks of human cancers. USP44 (ubiquitin specific peptidase 44) is an important molecule that plays a regulatory role in the mitotic checkpoint and USP44 loss causes chromosome mis-segregation, aneuploidy and tumorigenesis in vivo. In this study, it was investigated the immunoexpression of USP44 in 28 malignant salivary gland neoplasms and associated the results with DNA ploidy status assessed by image cytometry. USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size. On this basis, it may be concluded that the aneuploidy of the salivary gland cancers included in this study was not driven by loss of USP44 protein expression.
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spelling DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expressionubiquitin specific proteasemucoepidermoid carcinomaadenoid cystic carcinomapolymorphous low grade adenocarcinomacarcinoma ex-pleomorphic adenomaepithelial-myoepithelial carcinoma.Chromosomal instability, leading to aneuploidy, is one of the hallmarks of human cancers. USP44 (ubiquitin specific peptidase 44) is an important molecule that plays a regulatory role in the mitotic checkpoint and USP44 loss causes chromosome mis-segregation, aneuploidy and tumorigenesis in vivo. In this study, it was investigated the immunoexpression of USP44 in 28 malignant salivary gland neoplasms and associated the results with DNA ploidy status assessed by image cytometry. USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size. On this basis, it may be concluded that the aneuploidy of the salivary gland cancers included in this study was not driven by loss of USP44 protein expression.Fundação Odontológica de Ribeirão Preto2017-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000200148Brazilian Dental Journal v.28 n.2 2017reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440201701018info:eu-repo/semantics/openAccessBernardes,Vanessa FátimaOdell,Edward WGomez,Ricardo SantiagoGomes,Carolina Cavalierieng2018-02-01T00:00:00Zoai:scielo:S0103-64402017000200148Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2018-02-01T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
spellingShingle DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
Bernardes,Vanessa Fátima
ubiquitin specific protease
mucoepidermoid carcinoma
adenoid cystic carcinoma
polymorphous low grade adenocarcinoma
carcinoma ex-pleomorphic adenoma
epithelial-myoepithelial carcinoma.
title_short DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title_full DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title_fullStr DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title_full_unstemmed DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
title_sort DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression
author Bernardes,Vanessa Fátima
author_facet Bernardes,Vanessa Fátima
Odell,Edward W
Gomez,Ricardo Santiago
Gomes,Carolina Cavalieri
author_role author
author2 Odell,Edward W
Gomez,Ricardo Santiago
Gomes,Carolina Cavalieri
author2_role author
author
author
dc.contributor.author.fl_str_mv Bernardes,Vanessa Fátima
Odell,Edward W
Gomez,Ricardo Santiago
Gomes,Carolina Cavalieri
dc.subject.por.fl_str_mv ubiquitin specific protease
mucoepidermoid carcinoma
adenoid cystic carcinoma
polymorphous low grade adenocarcinoma
carcinoma ex-pleomorphic adenoma
epithelial-myoepithelial carcinoma.
topic ubiquitin specific protease
mucoepidermoid carcinoma
adenoid cystic carcinoma
polymorphous low grade adenocarcinoma
carcinoma ex-pleomorphic adenoma
epithelial-myoepithelial carcinoma.
description Chromosomal instability, leading to aneuploidy, is one of the hallmarks of human cancers. USP44 (ubiquitin specific peptidase 44) is an important molecule that plays a regulatory role in the mitotic checkpoint and USP44 loss causes chromosome mis-segregation, aneuploidy and tumorigenesis in vivo. In this study, it was investigated the immunoexpression of USP44 in 28 malignant salivary gland neoplasms and associated the results with DNA ploidy status assessed by image cytometry. USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size. On this basis, it may be concluded that the aneuploidy of the salivary gland cancers included in this study was not driven by loss of USP44 protein expression.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000200148
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000200148
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-6440201701018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.28 n.2 2017
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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