Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis

Detalhes bibliográficos
Autor(a) principal: d'Alessandro,André Fernandes
Data de Publicação: 2015
Outros Autores: Pinto,Fábio Roberto, Lin,Chin Shien, Kulcsar,Marco Aurélio Vamondes, Cernea,Cláudio Roberto, Brandão,Lenine Garcia, Matos,Leandro Luongo de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Otorhinolaryngology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000300248
Resumo: INTRODUCTION: Elective neck dissection is recommended in cases of oral cavity squamous cell carcinoma without lymph node metastasis because of the risk of occult metastasis. OBJECTIVE: The present study aimed to evaluate predictive factors for occult lymph node metastasis in patients with oral cavity squamous cell carcinoma treated with elective neck dissection and their impact on overall and disease-free survival. METHODS: Forty surgically treated patients were retrospectively included. RESULTS: Ten cases (25%) had lymphatic metastasis. Of the studied variables, perineural and angiolymphatic invasion in addition to tumor thickness were statistically associated with lymph node metastasis. Only angiolymphatic invasion was identified as an independent risk factor for occult metastasis in the logistic regression (OR = 39.3; p = 0.002). There was no association between overall and disease-free survival with the presence of occult lymph node metastasis. CONCLUSION: Metastatic disease rate was similar to that found in the literature. Perineural and angiolymphatic invasion and tumor thickness were associated with occult metastasis, but only angiolymphatic invasion showed to be an independent risk factor
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spelling Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis CarcinomaSquamous cellMouthLymphatic metastasisPrognosis INTRODUCTION: Elective neck dissection is recommended in cases of oral cavity squamous cell carcinoma without lymph node metastasis because of the risk of occult metastasis. OBJECTIVE: The present study aimed to evaluate predictive factors for occult lymph node metastasis in patients with oral cavity squamous cell carcinoma treated with elective neck dissection and their impact on overall and disease-free survival. METHODS: Forty surgically treated patients were retrospectively included. RESULTS: Ten cases (25%) had lymphatic metastasis. Of the studied variables, perineural and angiolymphatic invasion in addition to tumor thickness were statistically associated with lymph node metastasis. Only angiolymphatic invasion was identified as an independent risk factor for occult metastasis in the logistic regression (OR = 39.3; p = 0.002). There was no association between overall and disease-free survival with the presence of occult lymph node metastasis. CONCLUSION: Metastatic disease rate was similar to that found in the literature. Perineural and angiolymphatic invasion and tumor thickness were associated with occult metastasis, but only angiolymphatic invasion showed to be an independent risk factor Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000300248Brazilian Journal of Otorhinolaryngology v.81 n.3 2015reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2015.03.004info:eu-repo/semantics/openAccessd'Alessandro,André FernandesPinto,Fábio RobertoLin,Chin ShienKulcsar,Marco Aurélio VamondesCernea,Cláudio RobertoBrandão,Lenine GarciaMatos,Leandro Luongo deeng2015-07-14T00:00:00Zoai:scielo:S1808-86942015000300248Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2015-07-14T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false
dc.title.none.fl_str_mv Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
title Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
spellingShingle Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
d'Alessandro,André Fernandes
Carcinoma
Squamous cell
Mouth
Lymphatic metastasis
Prognosis
title_short Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
title_full Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
title_fullStr Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
title_full_unstemmed Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
title_sort Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
author d'Alessandro,André Fernandes
author_facet d'Alessandro,André Fernandes
Pinto,Fábio Roberto
Lin,Chin Shien
Kulcsar,Marco Aurélio Vamondes
Cernea,Cláudio Roberto
Brandão,Lenine Garcia
Matos,Leandro Luongo de
author_role author
author2 Pinto,Fábio Roberto
Lin,Chin Shien
Kulcsar,Marco Aurélio Vamondes
Cernea,Cláudio Roberto
Brandão,Lenine Garcia
Matos,Leandro Luongo de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv d'Alessandro,André Fernandes
Pinto,Fábio Roberto
Lin,Chin Shien
Kulcsar,Marco Aurélio Vamondes
Cernea,Cláudio Roberto
Brandão,Lenine Garcia
Matos,Leandro Luongo de
dc.subject.por.fl_str_mv Carcinoma
Squamous cell
Mouth
Lymphatic metastasis
Prognosis
topic Carcinoma
Squamous cell
Mouth
Lymphatic metastasis
Prognosis
description INTRODUCTION: Elective neck dissection is recommended in cases of oral cavity squamous cell carcinoma without lymph node metastasis because of the risk of occult metastasis. OBJECTIVE: The present study aimed to evaluate predictive factors for occult lymph node metastasis in patients with oral cavity squamous cell carcinoma treated with elective neck dissection and their impact on overall and disease-free survival. METHODS: Forty surgically treated patients were retrospectively included. RESULTS: Ten cases (25%) had lymphatic metastasis. Of the studied variables, perineural and angiolymphatic invasion in addition to tumor thickness were statistically associated with lymph node metastasis. Only angiolymphatic invasion was identified as an independent risk factor for occult metastasis in the logistic regression (OR = 39.3; p = 0.002). There was no association between overall and disease-free survival with the presence of occult lymph node metastasis. CONCLUSION: Metastatic disease rate was similar to that found in the literature. Perineural and angiolymphatic invasion and tumor thickness were associated with occult metastasis, but only angiolymphatic invasion showed to be an independent risk factor
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000300248
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000300248
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjorl.2015.03.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
dc.source.none.fl_str_mv Brazilian Journal of Otorhinolaryngology v.81 n.3 2015
reponame:Brazilian Journal of Otorhinolaryngology
instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron:ABORL-CCF
instname_str Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron_str ABORL-CCF
institution ABORL-CCF
reponame_str Brazilian Journal of Otorhinolaryngology
collection Brazilian Journal of Otorhinolaryngology
repository.name.fl_str_mv Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
repository.mail.fl_str_mv revista@aborlccf.org.br||revista@aborlccf.org.br
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