Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Otorhinolaryngology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000300248 |
Resumo: | INTRODUCTION: Elective neck dissection is recommended in cases of oral cavity squamous cell carcinoma without lymph node metastasis because of the risk of occult metastasis. OBJECTIVE: The present study aimed to evaluate predictive factors for occult lymph node metastasis in patients with oral cavity squamous cell carcinoma treated with elective neck dissection and their impact on overall and disease-free survival. METHODS: Forty surgically treated patients were retrospectively included. RESULTS: Ten cases (25%) had lymphatic metastasis. Of the studied variables, perineural and angiolymphatic invasion in addition to tumor thickness were statistically associated with lymph node metastasis. Only angiolymphatic invasion was identified as an independent risk factor for occult metastasis in the logistic regression (OR = 39.3; p = 0.002). There was no association between overall and disease-free survival with the presence of occult lymph node metastasis. CONCLUSION: Metastatic disease rate was similar to that found in the literature. Perineural and angiolymphatic invasion and tumor thickness were associated with occult metastasis, but only angiolymphatic invasion showed to be an independent risk factor |
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Brazilian Journal of Otorhinolaryngology |
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Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis CarcinomaSquamous cellMouthLymphatic metastasisPrognosis INTRODUCTION: Elective neck dissection is recommended in cases of oral cavity squamous cell carcinoma without lymph node metastasis because of the risk of occult metastasis. OBJECTIVE: The present study aimed to evaluate predictive factors for occult lymph node metastasis in patients with oral cavity squamous cell carcinoma treated with elective neck dissection and their impact on overall and disease-free survival. METHODS: Forty surgically treated patients were retrospectively included. RESULTS: Ten cases (25%) had lymphatic metastasis. Of the studied variables, perineural and angiolymphatic invasion in addition to tumor thickness were statistically associated with lymph node metastasis. Only angiolymphatic invasion was identified as an independent risk factor for occult metastasis in the logistic regression (OR = 39.3; p = 0.002). There was no association between overall and disease-free survival with the presence of occult lymph node metastasis. CONCLUSION: Metastatic disease rate was similar to that found in the literature. Perineural and angiolymphatic invasion and tumor thickness were associated with occult metastasis, but only angiolymphatic invasion showed to be an independent risk factor Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000300248Brazilian Journal of Otorhinolaryngology v.81 n.3 2015reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2015.03.004info:eu-repo/semantics/openAccessd'Alessandro,André FernandesPinto,Fábio RobertoLin,Chin ShienKulcsar,Marco Aurélio VamondesCernea,Cláudio RobertoBrandão,Lenine GarciaMatos,Leandro Luongo deeng2015-07-14T00:00:00Zoai:scielo:S1808-86942015000300248Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2015-07-14T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false |
dc.title.none.fl_str_mv |
Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis |
title |
Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis |
spellingShingle |
Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis d'Alessandro,André Fernandes Carcinoma Squamous cell Mouth Lymphatic metastasis Prognosis |
title_short |
Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis |
title_full |
Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis |
title_fullStr |
Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis |
title_full_unstemmed |
Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis |
title_sort |
Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis |
author |
d'Alessandro,André Fernandes |
author_facet |
d'Alessandro,André Fernandes Pinto,Fábio Roberto Lin,Chin Shien Kulcsar,Marco Aurélio Vamondes Cernea,Cláudio Roberto Brandão,Lenine Garcia Matos,Leandro Luongo de |
author_role |
author |
author2 |
Pinto,Fábio Roberto Lin,Chin Shien Kulcsar,Marco Aurélio Vamondes Cernea,Cláudio Roberto Brandão,Lenine Garcia Matos,Leandro Luongo de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
d'Alessandro,André Fernandes Pinto,Fábio Roberto Lin,Chin Shien Kulcsar,Marco Aurélio Vamondes Cernea,Cláudio Roberto Brandão,Lenine Garcia Matos,Leandro Luongo de |
dc.subject.por.fl_str_mv |
Carcinoma Squamous cell Mouth Lymphatic metastasis Prognosis |
topic |
Carcinoma Squamous cell Mouth Lymphatic metastasis Prognosis |
description |
INTRODUCTION: Elective neck dissection is recommended in cases of oral cavity squamous cell carcinoma without lymph node metastasis because of the risk of occult metastasis. OBJECTIVE: The present study aimed to evaluate predictive factors for occult lymph node metastasis in patients with oral cavity squamous cell carcinoma treated with elective neck dissection and their impact on overall and disease-free survival. METHODS: Forty surgically treated patients were retrospectively included. RESULTS: Ten cases (25%) had lymphatic metastasis. Of the studied variables, perineural and angiolymphatic invasion in addition to tumor thickness were statistically associated with lymph node metastasis. Only angiolymphatic invasion was identified as an independent risk factor for occult metastasis in the logistic regression (OR = 39.3; p = 0.002). There was no association between overall and disease-free survival with the presence of occult lymph node metastasis. CONCLUSION: Metastatic disease rate was similar to that found in the literature. Perineural and angiolymphatic invasion and tumor thickness were associated with occult metastasis, but only angiolymphatic invasion showed to be an independent risk factor |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000300248 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942015000300248 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjorl.2015.03.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
dc.source.none.fl_str_mv |
Brazilian Journal of Otorhinolaryngology v.81 n.3 2015 reponame:Brazilian Journal of Otorhinolaryngology instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) instacron:ABORL-CCF |
instname_str |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
instacron_str |
ABORL-CCF |
institution |
ABORL-CCF |
reponame_str |
Brazilian Journal of Otorhinolaryngology |
collection |
Brazilian Journal of Otorhinolaryngology |
repository.name.fl_str_mv |
Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
repository.mail.fl_str_mv |
revista@aborlccf.org.br||revista@aborlccf.org.br |
_version_ |
1754575991384047616 |