Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Otorhinolaryngology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200191 |
Resumo: | ABSTRACT INTRODUCTION: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. OBJECTIVE: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. METHODS: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. RESULTS: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p = 0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. CONCLUSION: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores. |
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Brazilian Journal of Otorhinolaryngology |
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Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitisSinusitisNasal polypsTherapeutic irrigationsCorticosteroidsEndoscopyABSTRACT INTRODUCTION: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. OBJECTIVE: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. METHODS: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. RESULTS: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p = 0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. CONCLUSION: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores.Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2016-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200191Brazilian Journal of Otorhinolaryngology v.82 n.2 2016reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2015.03.014info:eu-repo/semantics/openAccessKosugi,Eduardo MacotoMoussalem,Guilherme FignerSimões,Juliana CaminhaSouza,Rafael de Paula e Silva Felici deChen,Vitor GuoSaraceni Neto,PauloMendes Neto,José Arrudaeng2016-04-29T00:00:00Zoai:scielo:S1808-86942016000200191Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2016-04-29T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false |
dc.title.none.fl_str_mv |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
title |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
spellingShingle |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis Kosugi,Eduardo Macoto Sinusitis Nasal polyps Therapeutic irrigations Corticosteroids Endoscopy |
title_short |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
title_full |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
title_fullStr |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
title_full_unstemmed |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
title_sort |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
author |
Kosugi,Eduardo Macoto |
author_facet |
Kosugi,Eduardo Macoto Moussalem,Guilherme Figner Simões,Juliana Caminha Souza,Rafael de Paula e Silva Felici de Chen,Vitor Guo Saraceni Neto,Paulo Mendes Neto,José Arruda |
author_role |
author |
author2 |
Moussalem,Guilherme Figner Simões,Juliana Caminha Souza,Rafael de Paula e Silva Felici de Chen,Vitor Guo Saraceni Neto,Paulo Mendes Neto,José Arruda |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Kosugi,Eduardo Macoto Moussalem,Guilherme Figner Simões,Juliana Caminha Souza,Rafael de Paula e Silva Felici de Chen,Vitor Guo Saraceni Neto,Paulo Mendes Neto,José Arruda |
dc.subject.por.fl_str_mv |
Sinusitis Nasal polyps Therapeutic irrigations Corticosteroids Endoscopy |
topic |
Sinusitis Nasal polyps Therapeutic irrigations Corticosteroids Endoscopy |
description |
ABSTRACT INTRODUCTION: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. OBJECTIVE: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. METHODS: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. RESULTS: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p = 0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. CONCLUSION: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200191 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942016000200191 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjorl.2015.03.014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
dc.source.none.fl_str_mv |
Brazilian Journal of Otorhinolaryngology v.82 n.2 2016 reponame:Brazilian Journal of Otorhinolaryngology instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) instacron:ABORL-CCF |
instname_str |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
instacron_str |
ABORL-CCF |
institution |
ABORL-CCF |
reponame_str |
Brazilian Journal of Otorhinolaryngology |
collection |
Brazilian Journal of Otorhinolaryngology |
repository.name.fl_str_mv |
Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
repository.mail.fl_str_mv |
revista@aborlccf.org.br||revista@aborlccf.org.br |
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1754575991776215040 |