Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review

Detalhes bibliográficos
Autor(a) principal: Dinarte,Vanessa Ramos Pires
Data de Publicação: 2017
Outros Autores: Santos,Anemari Ramos Dinarte dos, Araújo,Luiza Ferreira de, Reis,Mariah Guieiro Alves dos, Tamashiro,Edwin, Valera,Fabiana Cardoso Pereira, Silva Júnior,Wilson Araújo da, Anselmo-Lima,Wilma Terezinha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Otorhinolaryngology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000600705
Resumo: Abstract Introduction: Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. Objective: The purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. Methods: A systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps. Results: Two studies found an association of MMP-9 and MMP-2 polymorphisms and chronic rhinosinusitis with nasal polyps, but not in patients with recurrent nasal polyps. Other studies found an association of nasal polyps with MMP-9 polymorphisms, but not with MMP-2 ones. There is evidence of an association of LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms and the risk of developing nasal polyps, especially when combined with chronic allergic rhinitis and asthma. Conclusion: Genetic studies on chronic rhinosinusitis with nasal polyps are promising and may offer insights into its pathophysiology, which is likely affected by multiple genetic factors.
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spelling Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic reviewPolymorphismRhinosinusitisPolypsAbstract Introduction: Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. Objective: The purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. Methods: A systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps. Results: Two studies found an association of MMP-9 and MMP-2 polymorphisms and chronic rhinosinusitis with nasal polyps, but not in patients with recurrent nasal polyps. Other studies found an association of nasal polyps with MMP-9 polymorphisms, but not with MMP-2 ones. There is evidence of an association of LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms and the risk of developing nasal polyps, especially when combined with chronic allergic rhinitis and asthma. Conclusion: Genetic studies on chronic rhinosinusitis with nasal polyps are promising and may offer insights into its pathophysiology, which is likely affected by multiple genetic factors.Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000600705Brazilian Journal of Otorhinolaryngology v.83 n.6 2017reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2017.03.002info:eu-repo/semantics/openAccessDinarte,Vanessa Ramos PiresSantos,Anemari Ramos Dinarte dosAraújo,Luiza Ferreira deReis,Mariah Guieiro Alves dosTamashiro,EdwinValera,Fabiana Cardoso PereiraSilva Júnior,Wilson Araújo daAnselmo-Lima,Wilma Terezinhaeng2017-12-11T00:00:00Zoai:scielo:S1808-86942017000600705Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2017-12-11T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false
dc.title.none.fl_str_mv Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review
title Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review
spellingShingle Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review
Dinarte,Vanessa Ramos Pires
Polymorphism
Rhinosinusitis
Polyps
title_short Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review
title_full Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review
title_fullStr Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review
title_full_unstemmed Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review
title_sort Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review
author Dinarte,Vanessa Ramos Pires
author_facet Dinarte,Vanessa Ramos Pires
Santos,Anemari Ramos Dinarte dos
Araújo,Luiza Ferreira de
Reis,Mariah Guieiro Alves dos
Tamashiro,Edwin
Valera,Fabiana Cardoso Pereira
Silva Júnior,Wilson Araújo da
Anselmo-Lima,Wilma Terezinha
author_role author
author2 Santos,Anemari Ramos Dinarte dos
Araújo,Luiza Ferreira de
Reis,Mariah Guieiro Alves dos
Tamashiro,Edwin
Valera,Fabiana Cardoso Pereira
Silva Júnior,Wilson Araújo da
Anselmo-Lima,Wilma Terezinha
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dinarte,Vanessa Ramos Pires
Santos,Anemari Ramos Dinarte dos
Araújo,Luiza Ferreira de
Reis,Mariah Guieiro Alves dos
Tamashiro,Edwin
Valera,Fabiana Cardoso Pereira
Silva Júnior,Wilson Araújo da
Anselmo-Lima,Wilma Terezinha
dc.subject.por.fl_str_mv Polymorphism
Rhinosinusitis
Polyps
topic Polymorphism
Rhinosinusitis
Polyps
description Abstract Introduction: Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. Objective: The purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. Methods: A systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps. Results: Two studies found an association of MMP-9 and MMP-2 polymorphisms and chronic rhinosinusitis with nasal polyps, but not in patients with recurrent nasal polyps. Other studies found an association of nasal polyps with MMP-9 polymorphisms, but not with MMP-2 ones. There is evidence of an association of LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms and the risk of developing nasal polyps, especially when combined with chronic allergic rhinitis and asthma. Conclusion: Genetic studies on chronic rhinosinusitis with nasal polyps are promising and may offer insights into its pathophysiology, which is likely affected by multiple genetic factors.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000600705
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000600705
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjorl.2017.03.002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
dc.source.none.fl_str_mv Brazilian Journal of Otorhinolaryngology v.83 n.6 2017
reponame:Brazilian Journal of Otorhinolaryngology
instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron:ABORL-CCF
instname_str Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron_str ABORL-CCF
institution ABORL-CCF
reponame_str Brazilian Journal of Otorhinolaryngology
collection Brazilian Journal of Otorhinolaryngology
repository.name.fl_str_mv Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
repository.mail.fl_str_mv revista@aborlccf.org.br||revista@aborlccf.org.br
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