Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Otorhinolaryngology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000600705 |
Resumo: | Abstract Introduction: Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. Objective: The purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. Methods: A systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps. Results: Two studies found an association of MMP-9 and MMP-2 polymorphisms and chronic rhinosinusitis with nasal polyps, but not in patients with recurrent nasal polyps. Other studies found an association of nasal polyps with MMP-9 polymorphisms, but not with MMP-2 ones. There is evidence of an association of LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms and the risk of developing nasal polyps, especially when combined with chronic allergic rhinitis and asthma. Conclusion: Genetic studies on chronic rhinosinusitis with nasal polyps are promising and may offer insights into its pathophysiology, which is likely affected by multiple genetic factors. |
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Brazilian Journal of Otorhinolaryngology |
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Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic reviewPolymorphismRhinosinusitisPolypsAbstract Introduction: Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. Objective: The purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. Methods: A systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps. Results: Two studies found an association of MMP-9 and MMP-2 polymorphisms and chronic rhinosinusitis with nasal polyps, but not in patients with recurrent nasal polyps. Other studies found an association of nasal polyps with MMP-9 polymorphisms, but not with MMP-2 ones. There is evidence of an association of LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms and the risk of developing nasal polyps, especially when combined with chronic allergic rhinitis and asthma. Conclusion: Genetic studies on chronic rhinosinusitis with nasal polyps are promising and may offer insights into its pathophysiology, which is likely affected by multiple genetic factors.Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000600705Brazilian Journal of Otorhinolaryngology v.83 n.6 2017reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2017.03.002info:eu-repo/semantics/openAccessDinarte,Vanessa Ramos PiresSantos,Anemari Ramos Dinarte dosAraújo,Luiza Ferreira deReis,Mariah Guieiro Alves dosTamashiro,EdwinValera,Fabiana Cardoso PereiraSilva Júnior,Wilson Araújo daAnselmo-Lima,Wilma Terezinhaeng2017-12-11T00:00:00Zoai:scielo:S1808-86942017000600705Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2017-12-11T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false |
dc.title.none.fl_str_mv |
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review |
title |
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review |
spellingShingle |
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review Dinarte,Vanessa Ramos Pires Polymorphism Rhinosinusitis Polyps |
title_short |
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review |
title_full |
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review |
title_fullStr |
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review |
title_full_unstemmed |
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review |
title_sort |
Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review |
author |
Dinarte,Vanessa Ramos Pires |
author_facet |
Dinarte,Vanessa Ramos Pires Santos,Anemari Ramos Dinarte dos Araújo,Luiza Ferreira de Reis,Mariah Guieiro Alves dos Tamashiro,Edwin Valera,Fabiana Cardoso Pereira Silva Júnior,Wilson Araújo da Anselmo-Lima,Wilma Terezinha |
author_role |
author |
author2 |
Santos,Anemari Ramos Dinarte dos Araújo,Luiza Ferreira de Reis,Mariah Guieiro Alves dos Tamashiro,Edwin Valera,Fabiana Cardoso Pereira Silva Júnior,Wilson Araújo da Anselmo-Lima,Wilma Terezinha |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Dinarte,Vanessa Ramos Pires Santos,Anemari Ramos Dinarte dos Araújo,Luiza Ferreira de Reis,Mariah Guieiro Alves dos Tamashiro,Edwin Valera,Fabiana Cardoso Pereira Silva Júnior,Wilson Araújo da Anselmo-Lima,Wilma Terezinha |
dc.subject.por.fl_str_mv |
Polymorphism Rhinosinusitis Polyps |
topic |
Polymorphism Rhinosinusitis Polyps |
description |
Abstract Introduction: Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. Objective: The purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. Methods: A systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps. Results: Two studies found an association of MMP-9 and MMP-2 polymorphisms and chronic rhinosinusitis with nasal polyps, but not in patients with recurrent nasal polyps. Other studies found an association of nasal polyps with MMP-9 polymorphisms, but not with MMP-2 ones. There is evidence of an association of LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms and the risk of developing nasal polyps, especially when combined with chronic allergic rhinitis and asthma. Conclusion: Genetic studies on chronic rhinosinusitis with nasal polyps are promising and may offer insights into its pathophysiology, which is likely affected by multiple genetic factors. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000600705 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942017000600705 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjorl.2017.03.002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
publisher.none.fl_str_mv |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
dc.source.none.fl_str_mv |
Brazilian Journal of Otorhinolaryngology v.83 n.6 2017 reponame:Brazilian Journal of Otorhinolaryngology instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) instacron:ABORL-CCF |
instname_str |
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
instacron_str |
ABORL-CCF |
institution |
ABORL-CCF |
reponame_str |
Brazilian Journal of Otorhinolaryngology |
collection |
Brazilian Journal of Otorhinolaryngology |
repository.name.fl_str_mv |
Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF) |
repository.mail.fl_str_mv |
revista@aborlccf.org.br||revista@aborlccf.org.br |
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1754575992789139456 |