Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps

Detalhes bibliográficos
Autor(a) principal: Tkachenko,Anton S.
Data de Publicação: 2020
Outros Autores: Gubina-Vakulyck,Galina I., Onishchenko,Anatolii I., Kalashnyk,Iulii M., Butko,Yaroslava O., Gorbach,Tatyana V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100400
Resumo: ABSTRACT Objective: The aim of our research is to assess fascin expression in nasal tissues of patients with chronic rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps. Methods: Fascin expression in nasal tissues of 11 CRSwNP patients and 10 CRSsNP patients was immunohistochemically evaluated and compared with control subjects. Results: Fascin was found to be strongly expressed in epithelial cells in polyps in CRSwNP and nasal tissue in CRSsNP. Its strong expression was observed both in lamina propria and nasal epithelial cells in CRSsNP. Fascin overexpression in nasal mucosa in CRSwNP was more pronounced compared with CRSsNP. In addition, proliferating epithelial cells in polyp tissue were weakly immunostained, whereas mature cells expressed much more fascin. Conclusion: CRSwNP and CRSsNP are associated with fascin overexpression, which makes fascin a promising target for therapeutic interventions.
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spelling Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polypsfascinnasal polypschronic rhinosinusitisactinsepithelial-mesenchymal transitionABSTRACT Objective: The aim of our research is to assess fascin expression in nasal tissues of patients with chronic rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps. Methods: Fascin expression in nasal tissues of 11 CRSwNP patients and 10 CRSsNP patients was immunohistochemically evaluated and compared with control subjects. Results: Fascin was found to be strongly expressed in epithelial cells in polyps in CRSwNP and nasal tissue in CRSsNP. Its strong expression was observed both in lamina propria and nasal epithelial cells in CRSsNP. Fascin overexpression in nasal mucosa in CRSwNP was more pronounced compared with CRSsNP. In addition, proliferating epithelial cells in polyp tissue were weakly immunostained, whereas mature cells expressed much more fascin. Conclusion: CRSwNP and CRSsNP are associated with fascin overexpression, which makes fascin a promising target for therapeutic interventions.Sociedade Brasileira de Patologia Clínica2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100400Jornal Brasileiro de Patologia e Medicina Laboratorial v.56 2020reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20200007info:eu-repo/semantics/openAccessTkachenko,Anton S.Gubina-Vakulyck,Galina I.Onishchenko,Anatolii I.Kalashnyk,Iulii M.Butko,Yaroslava O.Gorbach,Tatyana V.eng2020-03-12T00:00:00Zoai:scielo:S1676-24442020000100400Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2020-03-12T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps
title Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps
spellingShingle Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps
Tkachenko,Anton S.
fascin
nasal polyps
chronic rhinosinusitis
actins
epithelial-mesenchymal transition
title_short Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps
title_full Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps
title_fullStr Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps
title_full_unstemmed Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps
title_sort Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps
author Tkachenko,Anton S.
author_facet Tkachenko,Anton S.
Gubina-Vakulyck,Galina I.
Onishchenko,Anatolii I.
Kalashnyk,Iulii M.
Butko,Yaroslava O.
Gorbach,Tatyana V.
author_role author
author2 Gubina-Vakulyck,Galina I.
Onishchenko,Anatolii I.
Kalashnyk,Iulii M.
Butko,Yaroslava O.
Gorbach,Tatyana V.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Tkachenko,Anton S.
Gubina-Vakulyck,Galina I.
Onishchenko,Anatolii I.
Kalashnyk,Iulii M.
Butko,Yaroslava O.
Gorbach,Tatyana V.
dc.subject.por.fl_str_mv fascin
nasal polyps
chronic rhinosinusitis
actins
epithelial-mesenchymal transition
topic fascin
nasal polyps
chronic rhinosinusitis
actins
epithelial-mesenchymal transition
description ABSTRACT Objective: The aim of our research is to assess fascin expression in nasal tissues of patients with chronic rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps. Methods: Fascin expression in nasal tissues of 11 CRSwNP patients and 10 CRSsNP patients was immunohistochemically evaluated and compared with control subjects. Results: Fascin was found to be strongly expressed in epithelial cells in polyps in CRSwNP and nasal tissue in CRSsNP. Its strong expression was observed both in lamina propria and nasal epithelial cells in CRSsNP. Fascin overexpression in nasal mucosa in CRSwNP was more pronounced compared with CRSsNP. In addition, proliferating epithelial cells in polyp tissue were weakly immunostained, whereas mature cells expressed much more fascin. Conclusion: CRSwNP and CRSsNP are associated with fascin overexpression, which makes fascin a promising target for therapeutic interventions.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100400
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100400
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20200007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.56 2020
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
instacron:SBP
instname_str Sociedade Brasileira de Patologia (SBP)
instacron_str SBP
institution SBP
reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
collection Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
repository.mail.fl_str_mv ||jbpml@sbpc.org.br
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