A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss

Detalhes bibliográficos
Autor(a) principal: Yu,Gun Hee
Data de Publicação: 2019
Outros Autores: Choi,Yong-Jun, Jung,Hahn Jin, Lim,Yun-Sung, Park,Seok-Won, Cho,Chang Gun, Park,Joo Hyun
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Otorhinolaryngology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942019000600733
Resumo: Abstract Introduction: Glucocorticoids are considered the first-line therapy for sudden sensorineural hearing loss. But there is currently no consensus on administering them as a single dose versus multiple divided daily doses. Objective: We aim to evaluate the treatment outcome of sudden sensorineural hearing loss between a single-dose and multiple divided daily doses of steroid treatment. Methods: A total of 94 patients who were diagnosed and treated for sudden sensorineural hearing loss and followed up for more than three months were reviewed retrospectively. Patients were divided into single-dose and multiple divided-dose groups, based on their medication regimens. Hearing thresholds were repeatedly measured: on the initial visit and 1 week, 1 month, and 3 months after the initial treatment. Treatment outcomes were analyzed by comparing hearing recovery rates and post-treatment audiometric changes. Results: The hearing threshold was significantly reduced at three months post-treatment in both groups. The hearing recovery rate of the single-dose group was significantly higher than that of the multiple divided-dose groups. Audiometric changes showed no statistical difference either in pure tone threshold or speech discrimination. Conclusion: When oral steroids are indicated for sudden sensorineural hearing loss, both a single dose and multiple divided doses can be effective for treatment and have comparable results. However, the single-dose regimen seems to be more efficacious than the divided-dose regimen.
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spelling A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing lossSudden sensorineural hearing lossSteroidDoseRegimenAbstract Introduction: Glucocorticoids are considered the first-line therapy for sudden sensorineural hearing loss. But there is currently no consensus on administering them as a single dose versus multiple divided daily doses. Objective: We aim to evaluate the treatment outcome of sudden sensorineural hearing loss between a single-dose and multiple divided daily doses of steroid treatment. Methods: A total of 94 patients who were diagnosed and treated for sudden sensorineural hearing loss and followed up for more than three months were reviewed retrospectively. Patients were divided into single-dose and multiple divided-dose groups, based on their medication regimens. Hearing thresholds were repeatedly measured: on the initial visit and 1 week, 1 month, and 3 months after the initial treatment. Treatment outcomes were analyzed by comparing hearing recovery rates and post-treatment audiometric changes. Results: The hearing threshold was significantly reduced at three months post-treatment in both groups. The hearing recovery rate of the single-dose group was significantly higher than that of the multiple divided-dose groups. Audiometric changes showed no statistical difference either in pure tone threshold or speech discrimination. Conclusion: When oral steroids are indicated for sudden sensorineural hearing loss, both a single dose and multiple divided doses can be effective for treatment and have comparable results. However, the single-dose regimen seems to be more efficacious than the divided-dose regimen.Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942019000600733Brazilian Journal of Otorhinolaryngology v.85 n.6 2019reponame:Brazilian Journal of Otorhinolaryngologyinstname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)instacron:ABORL-CCF10.1016/j.bjorl.2018.06.001info:eu-repo/semantics/openAccessYu,Gun HeeChoi,Yong-JunJung,Hahn JinLim,Yun-SungPark,Seok-WonCho,Chang GunPark,Joo Hyuneng2019-12-09T00:00:00Zoai:scielo:S1808-86942019000600733Revistahttp://www.bjorl.org.br/https://old.scielo.br/oai/scielo-oai.phprevista@aborlccf.org.br||revista@aborlccf.org.br1808-86861808-8686opendoar:2019-12-09T00:00Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)false
dc.title.none.fl_str_mv A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss
title A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss
spellingShingle A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss
Yu,Gun Hee
Sudden sensorineural hearing loss
Steroid
Dose
Regimen
title_short A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss
title_full A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss
title_fullStr A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss
title_full_unstemmed A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss
title_sort A comparison of single-dose and multiple divided daily-dose oral steroids for sudden sensorineural hearing loss
author Yu,Gun Hee
author_facet Yu,Gun Hee
Choi,Yong-Jun
Jung,Hahn Jin
Lim,Yun-Sung
Park,Seok-Won
Cho,Chang Gun
Park,Joo Hyun
author_role author
author2 Choi,Yong-Jun
Jung,Hahn Jin
Lim,Yun-Sung
Park,Seok-Won
Cho,Chang Gun
Park,Joo Hyun
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Yu,Gun Hee
Choi,Yong-Jun
Jung,Hahn Jin
Lim,Yun-Sung
Park,Seok-Won
Cho,Chang Gun
Park,Joo Hyun
dc.subject.por.fl_str_mv Sudden sensorineural hearing loss
Steroid
Dose
Regimen
topic Sudden sensorineural hearing loss
Steroid
Dose
Regimen
description Abstract Introduction: Glucocorticoids are considered the first-line therapy for sudden sensorineural hearing loss. But there is currently no consensus on administering them as a single dose versus multiple divided daily doses. Objective: We aim to evaluate the treatment outcome of sudden sensorineural hearing loss between a single-dose and multiple divided daily doses of steroid treatment. Methods: A total of 94 patients who were diagnosed and treated for sudden sensorineural hearing loss and followed up for more than three months were reviewed retrospectively. Patients were divided into single-dose and multiple divided-dose groups, based on their medication regimens. Hearing thresholds were repeatedly measured: on the initial visit and 1 week, 1 month, and 3 months after the initial treatment. Treatment outcomes were analyzed by comparing hearing recovery rates and post-treatment audiometric changes. Results: The hearing threshold was significantly reduced at three months post-treatment in both groups. The hearing recovery rate of the single-dose group was significantly higher than that of the multiple divided-dose groups. Audiometric changes showed no statistical difference either in pure tone threshold or speech discrimination. Conclusion: When oral steroids are indicated for sudden sensorineural hearing loss, both a single dose and multiple divided doses can be effective for treatment and have comparable results. However, the single-dose regimen seems to be more efficacious than the divided-dose regimen.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942019000600733
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942019000600733
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjorl.2018.06.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
publisher.none.fl_str_mv Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
dc.source.none.fl_str_mv Brazilian Journal of Otorhinolaryngology v.85 n.6 2019
reponame:Brazilian Journal of Otorhinolaryngology
instname:Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron:ABORL-CCF
instname_str Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron_str ABORL-CCF
institution ABORL-CCF
reponame_str Brazilian Journal of Otorhinolaryngology
collection Brazilian Journal of Otorhinolaryngology
repository.name.fl_str_mv Brazilian Journal of Otorhinolaryngology - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
repository.mail.fl_str_mv revista@aborlccf.org.br||revista@aborlccf.org.br
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