Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases

Detalhes bibliográficos
Autor(a) principal: Torrão,Andréa S.
Data de Publicação: 2012
Outros Autores: Café-Mendes,Cecilia C., Real,Caroline C., Hernandes,Marina S., Ferreira,Ana F. B., Santos,Taisa O., Chaves-Kirsten,Gabriela P., Mazucanti,Caio H. Y., Ferro,Emer S., Scavone,Cristoforo, Britto,Luiz R. G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000600006
Resumo: Neurodegenerative disorders are undoubtedly an increasing problem in the health sciences, given the increase of life expectancy and occasional vicious life style. Despite the fact that the mechanisms of such diseases are far from being completely understood, a large number of studies that derive from both the basic science and clinical approaches have contributed substantial data in that direction. In this review, it is discussed several frontiers of basic research on Parkinson´s and Alzheimer´s diseases, in which research groups from three departments of the Institute of Biomedical Sciences of the University of São Paulo have been involved in a multidisciplinary effort. The main focus of the review involves the animal models that have been developed to study cellular and molecular aspects of those neurodegenerative diseases, including oxidative stress, insulin signaling and proteomic analyses, among others. We anticipate that this review will help the group determine future directions of joint research in the field and, more importantly, set the level of cooperation we plan to develop in collaboration with colleagues of the Nucleus for Applied Neuroscience Research that are mostly involved with clinical research in the same field.
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spelling Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseasesNeurodegenerationNeuroprotectionOxidative StressStreptozotocinNADPHoxidaseNeurodegenerative disorders are undoubtedly an increasing problem in the health sciences, given the increase of life expectancy and occasional vicious life style. Despite the fact that the mechanisms of such diseases are far from being completely understood, a large number of studies that derive from both the basic science and clinical approaches have contributed substantial data in that direction. In this review, it is discussed several frontiers of basic research on Parkinson´s and Alzheimer´s diseases, in which research groups from three departments of the Institute of Biomedical Sciences of the University of São Paulo have been involved in a multidisciplinary effort. The main focus of the review involves the animal models that have been developed to study cellular and molecular aspects of those neurodegenerative diseases, including oxidative stress, insulin signaling and proteomic analyses, among others. We anticipate that this review will help the group determine future directions of joint research in the field and, more importantly, set the level of cooperation we plan to develop in collaboration with colleagues of the Nucleus for Applied Neuroscience Research that are mostly involved with clinical research in the same field.Associação Brasileira de Psiquiatria2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000600006Brazilian Journal of Psychiatry v.34 suppl.2 2012reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1016/j.rbp.2012.08.004info:eu-repo/semantics/openAccessTorrão,Andréa S.Café-Mendes,Cecilia C.Real,Caroline C.Hernandes,Marina S.Ferreira,Ana F. B.Santos,Taisa O.Chaves-Kirsten,Gabriela P.Mazucanti,Caio H. Y.Ferro,Emer S.Scavone,CristoforoBritto,Luiz R. G.eng2013-01-17T00:00:00Zoai:scielo:S1516-44462012000600006Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2013-01-17T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
title Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
spellingShingle Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
Torrão,Andréa S.
Neurodegeneration
Neuroprotection
Oxidative Stress
Streptozotocin
NADPHoxidase
title_short Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
title_full Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
title_fullStr Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
title_full_unstemmed Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
title_sort Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
author Torrão,Andréa S.
author_facet Torrão,Andréa S.
Café-Mendes,Cecilia C.
Real,Caroline C.
Hernandes,Marina S.
Ferreira,Ana F. B.
Santos,Taisa O.
Chaves-Kirsten,Gabriela P.
Mazucanti,Caio H. Y.
Ferro,Emer S.
Scavone,Cristoforo
Britto,Luiz R. G.
author_role author
author2 Café-Mendes,Cecilia C.
Real,Caroline C.
Hernandes,Marina S.
Ferreira,Ana F. B.
Santos,Taisa O.
Chaves-Kirsten,Gabriela P.
Mazucanti,Caio H. Y.
Ferro,Emer S.
Scavone,Cristoforo
Britto,Luiz R. G.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Torrão,Andréa S.
Café-Mendes,Cecilia C.
Real,Caroline C.
Hernandes,Marina S.
Ferreira,Ana F. B.
Santos,Taisa O.
Chaves-Kirsten,Gabriela P.
Mazucanti,Caio H. Y.
Ferro,Emer S.
Scavone,Cristoforo
Britto,Luiz R. G.
dc.subject.por.fl_str_mv Neurodegeneration
Neuroprotection
Oxidative Stress
Streptozotocin
NADPHoxidase
topic Neurodegeneration
Neuroprotection
Oxidative Stress
Streptozotocin
NADPHoxidase
description Neurodegenerative disorders are undoubtedly an increasing problem in the health sciences, given the increase of life expectancy and occasional vicious life style. Despite the fact that the mechanisms of such diseases are far from being completely understood, a large number of studies that derive from both the basic science and clinical approaches have contributed substantial data in that direction. In this review, it is discussed several frontiers of basic research on Parkinson´s and Alzheimer´s diseases, in which research groups from three departments of the Institute of Biomedical Sciences of the University of São Paulo have been involved in a multidisciplinary effort. The main focus of the review involves the animal models that have been developed to study cellular and molecular aspects of those neurodegenerative diseases, including oxidative stress, insulin signaling and proteomic analyses, among others. We anticipate that this review will help the group determine future directions of joint research in the field and, more importantly, set the level of cooperation we plan to develop in collaboration with colleagues of the Nucleus for Applied Neuroscience Research that are mostly involved with clinical research in the same field.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000600006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000600006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.rbp.2012.08.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Brazilian Journal of Psychiatry v.34 suppl.2 2012
reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
collection Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
repository.name.fl_str_mv Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv ||rbp@abpbrasil.org.br
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