Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000600006 |
Resumo: | Neurodegenerative disorders are undoubtedly an increasing problem in the health sciences, given the increase of life expectancy and occasional vicious life style. Despite the fact that the mechanisms of such diseases are far from being completely understood, a large number of studies that derive from both the basic science and clinical approaches have contributed substantial data in that direction. In this review, it is discussed several frontiers of basic research on Parkinson´s and Alzheimer´s diseases, in which research groups from three departments of the Institute of Biomedical Sciences of the University of São Paulo have been involved in a multidisciplinary effort. The main focus of the review involves the animal models that have been developed to study cellular and molecular aspects of those neurodegenerative diseases, including oxidative stress, insulin signaling and proteomic analyses, among others. We anticipate that this review will help the group determine future directions of joint research in the field and, more importantly, set the level of cooperation we plan to develop in collaboration with colleagues of the Nucleus for Applied Neuroscience Research that are mostly involved with clinical research in the same field. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseasesNeurodegenerationNeuroprotectionOxidative StressStreptozotocinNADPHoxidaseNeurodegenerative disorders are undoubtedly an increasing problem in the health sciences, given the increase of life expectancy and occasional vicious life style. Despite the fact that the mechanisms of such diseases are far from being completely understood, a large number of studies that derive from both the basic science and clinical approaches have contributed substantial data in that direction. In this review, it is discussed several frontiers of basic research on Parkinson´s and Alzheimer´s diseases, in which research groups from three departments of the Institute of Biomedical Sciences of the University of São Paulo have been involved in a multidisciplinary effort. The main focus of the review involves the animal models that have been developed to study cellular and molecular aspects of those neurodegenerative diseases, including oxidative stress, insulin signaling and proteomic analyses, among others. We anticipate that this review will help the group determine future directions of joint research in the field and, more importantly, set the level of cooperation we plan to develop in collaboration with colleagues of the Nucleus for Applied Neuroscience Research that are mostly involved with clinical research in the same field.Associação Brasileira de Psiquiatria2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000600006Brazilian Journal of Psychiatry v.34 suppl.2 2012reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1016/j.rbp.2012.08.004info:eu-repo/semantics/openAccessTorrão,Andréa S.Café-Mendes,Cecilia C.Real,Caroline C.Hernandes,Marina S.Ferreira,Ana F. B.Santos,Taisa O.Chaves-Kirsten,Gabriela P.Mazucanti,Caio H. Y.Ferro,Emer S.Scavone,CristoforoBritto,Luiz R. G.eng2013-01-17T00:00:00Zoai:scielo:S1516-44462012000600006Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2013-01-17T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases |
title |
Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases |
spellingShingle |
Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases Torrão,Andréa S. Neurodegeneration Neuroprotection Oxidative Stress Streptozotocin NADPHoxidase |
title_short |
Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases |
title_full |
Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases |
title_fullStr |
Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases |
title_full_unstemmed |
Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases |
title_sort |
Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases |
author |
Torrão,Andréa S. |
author_facet |
Torrão,Andréa S. Café-Mendes,Cecilia C. Real,Caroline C. Hernandes,Marina S. Ferreira,Ana F. B. Santos,Taisa O. Chaves-Kirsten,Gabriela P. Mazucanti,Caio H. Y. Ferro,Emer S. Scavone,Cristoforo Britto,Luiz R. G. |
author_role |
author |
author2 |
Café-Mendes,Cecilia C. Real,Caroline C. Hernandes,Marina S. Ferreira,Ana F. B. Santos,Taisa O. Chaves-Kirsten,Gabriela P. Mazucanti,Caio H. Y. Ferro,Emer S. Scavone,Cristoforo Britto,Luiz R. G. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Torrão,Andréa S. Café-Mendes,Cecilia C. Real,Caroline C. Hernandes,Marina S. Ferreira,Ana F. B. Santos,Taisa O. Chaves-Kirsten,Gabriela P. Mazucanti,Caio H. Y. Ferro,Emer S. Scavone,Cristoforo Britto,Luiz R. G. |
dc.subject.por.fl_str_mv |
Neurodegeneration Neuroprotection Oxidative Stress Streptozotocin NADPHoxidase |
topic |
Neurodegeneration Neuroprotection Oxidative Stress Streptozotocin NADPHoxidase |
description |
Neurodegenerative disorders are undoubtedly an increasing problem in the health sciences, given the increase of life expectancy and occasional vicious life style. Despite the fact that the mechanisms of such diseases are far from being completely understood, a large number of studies that derive from both the basic science and clinical approaches have contributed substantial data in that direction. In this review, it is discussed several frontiers of basic research on Parkinson´s and Alzheimer´s diseases, in which research groups from three departments of the Institute of Biomedical Sciences of the University of São Paulo have been involved in a multidisciplinary effort. The main focus of the review involves the animal models that have been developed to study cellular and molecular aspects of those neurodegenerative diseases, including oxidative stress, insulin signaling and proteomic analyses, among others. We anticipate that this review will help the group determine future directions of joint research in the field and, more importantly, set the level of cooperation we plan to develop in collaboration with colleagues of the Nucleus for Applied Neuroscience Research that are mostly involved with clinical research in the same field. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000600006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000600006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.rbp.2012.08.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.34 suppl.2 2012 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
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1754212555937546240 |