Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000500007 |
Resumo: | Anxiety is an important component of the psychopathology of the obsessive-compulsive disorder (OCD). So far, most interventions that have proven to be effective for treating OCD are similar to those developed for other anxiety disorders. However, neurobiological studies of OCD came to conclusions that are not always compatible with those previously associated with other anxiety disorders. OBJECTIVES: The aim of this study is to review the degree of overlap between OCD and other anxiety disorders phenomenology and pathophysiology to support the rationale that guides research in this field. RESULTS: Clues about the neurocircuits involved in the manifestation of anxiety disorders have been obtained through the study of animal anxiety models, and structural and functional neuroimaging in humans. These investigations suggest that in OCD, in addition to dysfunction in cortico-striatal pathways, the functioning of an alternative neurocircuitry, which involves amygdalo-cortical interactions and participates in fear conditioning and extinction processes, may be impaired. CONCLUSION: It is likely that anxiety is a relevant dimension of OCD that impacts on other features of this disorder. Therefore, future studies may benefit from the investigation of the expression of fear and anxiety by OCD patients according to their type of obsessions and compulsions, age of OCD onset, comorbidities, and patterns of treatment response. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxietyobsessive-compulsive disorderanxiety disordersfearstress disorders, post-traumaticneuroimagingepidemiologytreatmentAnxiety is an important component of the psychopathology of the obsessive-compulsive disorder (OCD). So far, most interventions that have proven to be effective for treating OCD are similar to those developed for other anxiety disorders. However, neurobiological studies of OCD came to conclusions that are not always compatible with those previously associated with other anxiety disorders. OBJECTIVES: The aim of this study is to review the degree of overlap between OCD and other anxiety disorders phenomenology and pathophysiology to support the rationale that guides research in this field. RESULTS: Clues about the neurocircuits involved in the manifestation of anxiety disorders have been obtained through the study of animal anxiety models, and structural and functional neuroimaging in humans. These investigations suggest that in OCD, in addition to dysfunction in cortico-striatal pathways, the functioning of an alternative neurocircuitry, which involves amygdalo-cortical interactions and participates in fear conditioning and extinction processes, may be impaired. CONCLUSION: It is likely that anxiety is a relevant dimension of OCD that impacts on other features of this disorder. Therefore, future studies may benefit from the investigation of the expression of fear and anxiety by OCD patients according to their type of obsessions and compulsions, age of OCD onset, comorbidities, and patterns of treatment response.Associação Brasileira de Psiquiatria2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000500007Brazilian Journal of Psychiatry v.34 suppl.1 2012reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/S1516-44462012000500007info:eu-repo/semantics/openAccessDiniz,Juliana BeloMiguel,Euripedes ConstantinoOliveira,Amanda Ribeiro deReimer,Adriano EdgarBrandão,Marcus LiraMathis,Maria Alice deBatistuzzo,Marcelo CamargoCosta,Daniel Lucas ConceiçãoHoexter,Marcelo Queirozeng2012-06-19T00:00:00Zoai:scielo:S1516-44462012000500007Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2012-06-19T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety |
title |
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety |
spellingShingle |
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety Diniz,Juliana Belo obsessive-compulsive disorder anxiety disorders fear stress disorders, post-traumatic neuroimaging epidemiology treatment |
title_short |
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety |
title_full |
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety |
title_fullStr |
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety |
title_full_unstemmed |
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety |
title_sort |
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety |
author |
Diniz,Juliana Belo |
author_facet |
Diniz,Juliana Belo Miguel,Euripedes Constantino Oliveira,Amanda Ribeiro de Reimer,Adriano Edgar Brandão,Marcus Lira Mathis,Maria Alice de Batistuzzo,Marcelo Camargo Costa,Daniel Lucas Conceição Hoexter,Marcelo Queiroz |
author_role |
author |
author2 |
Miguel,Euripedes Constantino Oliveira,Amanda Ribeiro de Reimer,Adriano Edgar Brandão,Marcus Lira Mathis,Maria Alice de Batistuzzo,Marcelo Camargo Costa,Daniel Lucas Conceição Hoexter,Marcelo Queiroz |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Diniz,Juliana Belo Miguel,Euripedes Constantino Oliveira,Amanda Ribeiro de Reimer,Adriano Edgar Brandão,Marcus Lira Mathis,Maria Alice de Batistuzzo,Marcelo Camargo Costa,Daniel Lucas Conceição Hoexter,Marcelo Queiroz |
dc.subject.por.fl_str_mv |
obsessive-compulsive disorder anxiety disorders fear stress disorders, post-traumatic neuroimaging epidemiology treatment |
topic |
obsessive-compulsive disorder anxiety disorders fear stress disorders, post-traumatic neuroimaging epidemiology treatment |
description |
Anxiety is an important component of the psychopathology of the obsessive-compulsive disorder (OCD). So far, most interventions that have proven to be effective for treating OCD are similar to those developed for other anxiety disorders. However, neurobiological studies of OCD came to conclusions that are not always compatible with those previously associated with other anxiety disorders. OBJECTIVES: The aim of this study is to review the degree of overlap between OCD and other anxiety disorders phenomenology and pathophysiology to support the rationale that guides research in this field. RESULTS: Clues about the neurocircuits involved in the manifestation of anxiety disorders have been obtained through the study of animal anxiety models, and structural and functional neuroimaging in humans. These investigations suggest that in OCD, in addition to dysfunction in cortico-striatal pathways, the functioning of an alternative neurocircuitry, which involves amygdalo-cortical interactions and participates in fear conditioning and extinction processes, may be impaired. CONCLUSION: It is likely that anxiety is a relevant dimension of OCD that impacts on other features of this disorder. Therefore, future studies may benefit from the investigation of the expression of fear and anxiety by OCD patients according to their type of obsessions and compulsions, age of OCD onset, comorbidities, and patterns of treatment response. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000500007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000500007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-44462012000500007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.34 suppl.1 2012 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
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1754212555928109056 |