Sleep and circadian rhytms in treatment-resistant depression
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Debates em Psiquiatria (Online) |
DOI: | 10.25118/2763-9037.2014.v4.240 |
Texto Completo: | https://revistardp.org.br/revista/article/view/240 |
Resumo: | Sleep and circadian rhythm disturbances are key features of depression. Changes in sleep-wake cycle are often prodromal symptoms of depressive disorders and play a role in the pathophysiology of mood disorders. They predict the onset of a new episode, increase the risk of relapse and recurrence and can also be correlated with a growth in the risk of suicide. Persistent sleep disorders can increase refractoriness to treatment. Patients with treatment resistantdepression have an important circadian deregulation and decreased delta rhythm amplitude during sleep. The available treatments for sleep disorders include hypnotic medications and non-pharmacological interventions. Drugs such as benzodiazepine receptor agonists, melatonin agonists and serotonin type 2C receptors antagonists have been shown to be effective in the treatment of sleep problems in depressive patients. Nonpharmacological interventions such as cognitive-behavioral therapy and phototherapy are also useful, particularly when associated with antidepressant medication. |
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Debates em Psiquiatria (Online) |
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Sleep and circadian rhytms in treatment-resistant depressionSono e ritmos circadianos na depressão resistenteDepressãoDepressão resistenteTratamento dos transtornos do sonoDepressionTreatment resistant depressionTreatment of sleep disordersSleep and circadian rhythm disturbances are key features of depression. Changes in sleep-wake cycle are often prodromal symptoms of depressive disorders and play a role in the pathophysiology of mood disorders. They predict the onset of a new episode, increase the risk of relapse and recurrence and can also be correlated with a growth in the risk of suicide. Persistent sleep disorders can increase refractoriness to treatment. Patients with treatment resistantdepression have an important circadian deregulation and decreased delta rhythm amplitude during sleep. The available treatments for sleep disorders include hypnotic medications and non-pharmacological interventions. Drugs such as benzodiazepine receptor agonists, melatonin agonists and serotonin type 2C receptors antagonists have been shown to be effective in the treatment of sleep problems in depressive patients. Nonpharmacological interventions such as cognitive-behavioral therapy and phototherapy are also useful, particularly when associated with antidepressant medication.Os distúrbios do sono e do ritmo circadiano constituem características essenciais dos quadros depressivos. As alterações do ciclo vigília-sono são frequentemente sintomas prodrômicos dos transtornos depressivos e desempenham um papel na patofisiologia dos transtornos do humor. Essas alterações predizem um novo episódio, aumentam o risco de recaída e de recorrência e correlacionam com maior risco de suicídio. A permanência de transtornos de sono pode aumentar a refratariedade ao tratamento. Os pacientes com depressões resistentes ao tratamento farmacológico apresentam uma importante desregulação circadiana e diminuição da amplitude do ritmo delta durante o sono. Os tratamentos disponíveis para os distúrbios do sono na depressão resistente incluem medicações com efeitos hipnóticos e intervenções não farmacológicas. Drogas como os agonistas de receptores benzodiazepínicos, agonistas melatoninérgicos e antagonistas dos receptores serotonérgicos do tipo 2C têm demonstrado eficácia na regularização das alterações do sono em pacientes com depressão. Intervenções não farmacológicas como a terapia cognitivo-comportamental e a fototerapia também são úteis, particularmente quando associadas à medicação antidepressiva.Associação Brasileira de Psiquiatria2014-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-ReviewedRevisado por ParesAvaliado Pelos Paresapplication/pdfhttps://revistardp.org.br/revista/article/view/24010.25118/2763-9037.2014.v4.240Debates in Psychiatry; Vol. 4 No. 3 (2014); 6 -11Debates em Psiquiatria; Vol. 4 Núm. 3 (2014); 6 -11Debates em Psiquiatria; v. 4 n. 3 (2014); 6 -112763-90372236-918Xreponame:Debates em Psiquiatria (Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABPporhttps://revistardp.org.br/revista/article/view/240/216Copyright (c) 2014 Dirceu Zorzetto Filhohttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessFilho, Dirceu Zorzetto2022-06-03T01:21:59Zoai:ojs.emnuvens.com.br:article/240Revistahttps://revistardp.org.br/revista/oaiPUBhttps://revistardp.org.br/revista/oairdp@abp.org.br2763-90372236-918Xopendoar:2022-06-03T01:21:59Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
Sleep and circadian rhytms in treatment-resistant depression Sono e ritmos circadianos na depressão resistente |
title |
Sleep and circadian rhytms in treatment-resistant depression |
spellingShingle |
Sleep and circadian rhytms in treatment-resistant depression Sleep and circadian rhytms in treatment-resistant depression Filho, Dirceu Zorzetto Depressão Depressão resistente Tratamento dos transtornos do sono Depression Treatment resistant depression Treatment of sleep disorders Filho, Dirceu Zorzetto Depressão Depressão resistente Tratamento dos transtornos do sono Depression Treatment resistant depression Treatment of sleep disorders |
title_short |
Sleep and circadian rhytms in treatment-resistant depression |
title_full |
Sleep and circadian rhytms in treatment-resistant depression |
title_fullStr |
Sleep and circadian rhytms in treatment-resistant depression Sleep and circadian rhytms in treatment-resistant depression |
title_full_unstemmed |
Sleep and circadian rhytms in treatment-resistant depression Sleep and circadian rhytms in treatment-resistant depression |
title_sort |
Sleep and circadian rhytms in treatment-resistant depression |
author |
Filho, Dirceu Zorzetto |
author_facet |
Filho, Dirceu Zorzetto Filho, Dirceu Zorzetto |
author_role |
author |
dc.contributor.author.fl_str_mv |
Filho, Dirceu Zorzetto |
dc.subject.por.fl_str_mv |
Depressão Depressão resistente Tratamento dos transtornos do sono Depression Treatment resistant depression Treatment of sleep disorders |
topic |
Depressão Depressão resistente Tratamento dos transtornos do sono Depression Treatment resistant depression Treatment of sleep disorders |
description |
Sleep and circadian rhythm disturbances are key features of depression. Changes in sleep-wake cycle are often prodromal symptoms of depressive disorders and play a role in the pathophysiology of mood disorders. They predict the onset of a new episode, increase the risk of relapse and recurrence and can also be correlated with a growth in the risk of suicide. Persistent sleep disorders can increase refractoriness to treatment. Patients with treatment resistantdepression have an important circadian deregulation and decreased delta rhythm amplitude during sleep. The available treatments for sleep disorders include hypnotic medications and non-pharmacological interventions. Drugs such as benzodiazepine receptor agonists, melatonin agonists and serotonin type 2C receptors antagonists have been shown to be effective in the treatment of sleep problems in depressive patients. Nonpharmacological interventions such as cognitive-behavioral therapy and phototherapy are also useful, particularly when associated with antidepressant medication. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-Reviewed Revisado por Pares Avaliado Pelos Pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistardp.org.br/revista/article/view/240 10.25118/2763-9037.2014.v4.240 |
url |
https://revistardp.org.br/revista/article/view/240 |
identifier_str_mv |
10.25118/2763-9037.2014.v4.240 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revistardp.org.br/revista/article/view/240/216 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2014 Dirceu Zorzetto Filho https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2014 Dirceu Zorzetto Filho https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Debates in Psychiatry; Vol. 4 No. 3 (2014); 6 -11 Debates em Psiquiatria; Vol. 4 Núm. 3 (2014); 6 -11 Debates em Psiquiatria; v. 4 n. 3 (2014); 6 -11 2763-9037 2236-918X reponame:Debates em Psiquiatria (Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Debates em Psiquiatria (Online) |
collection |
Debates em Psiquiatria (Online) |
repository.name.fl_str_mv |
Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
rdp@abp.org.br |
_version_ |
1822182011150794752 |
dc.identifier.doi.none.fl_str_mv |
10.25118/2763-9037.2014.v4.240 |