Sleep and circadian rhytms in treatment-resistant depression

Detalhes bibliográficos
Autor(a) principal: Filho, Dirceu Zorzetto
Data de Publicação: 2014
Tipo de documento: Artigo
Idioma: por
Título da fonte: Debates em Psiquiatria (Online)
DOI: 10.25118/2763-9037.2014.v4.240
Texto Completo: https://revistardp.org.br/revista/article/view/240
Resumo: Sleep and circadian rhythm disturbances are key features of depression. Changes in sleep-wake cycle are often prodromal symptoms of depressive disorders and play a role in the pathophysiology of mood disorders. They predict the onset of a new episode, increase the risk of relapse and recurrence and can also be correlated with a growth in the risk of suicide. Persistent sleep disorders can increase refractoriness to treatment. Patients with treatment resistantdepression have an important circadian deregulation and decreased delta rhythm amplitude during sleep. The available treatments for sleep disorders include hypnotic medications and non-pharmacological interventions. Drugs such as benzodiazepine receptor agonists, melatonin agonists and serotonin type 2C receptors antagonists have been shown to be effective in the treatment of sleep problems in depressive patients. Nonpharmacological interventions such as cognitive-behavioral therapy and phototherapy are also useful, particularly when associated with antidepressant medication.
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spelling Sleep and circadian rhytms in treatment-resistant depressionSono e ritmos circadianos na depressão resistenteDepressãoDepressão resistenteTratamento dos transtornos do sonoDepressionTreatment resistant depressionTreatment of sleep disordersSleep and circadian rhythm disturbances are key features of depression. Changes in sleep-wake cycle are often prodromal symptoms of depressive disorders and play a role in the pathophysiology of mood disorders. They predict the onset of a new episode, increase the risk of relapse and recurrence and can also be correlated with a growth in the risk of suicide. Persistent sleep disorders can increase refractoriness to treatment. Patients with treatment resistantdepression have an important circadian deregulation and decreased delta rhythm amplitude during sleep. The available treatments for sleep disorders include hypnotic medications and non-pharmacological interventions. Drugs such as benzodiazepine receptor agonists, melatonin agonists and serotonin type 2C receptors antagonists have been shown to be effective in the treatment of sleep problems in depressive patients. Nonpharmacological interventions such as cognitive-behavioral therapy and phototherapy are also useful, particularly when associated with antidepressant medication.Os distúrbios do sono e do ritmo circadiano constituem características essenciais dos quadros depressivos. As alterações do ciclo vigília-sono são frequentemente sintomas prodrômicos dos transtornos depressivos e desempenham um papel na patofisiologia dos transtornos do humor. Essas alterações predizem um novo episódio, aumentam o risco de recaída e de recorrência e correlacionam com maior risco de suicídio. A permanência de transtornos de sono pode aumentar a refratariedade ao tratamento. Os pacientes com depressões resistentes ao tratamento farmacológico apresentam uma importante desregulação circadiana e diminuição da amplitude do ritmo delta durante o sono. Os tratamentos disponíveis para os distúrbios do sono na depressão resistente incluem medicações com efeitos hipnóticos e intervenções não farmacológicas. Drogas como os agonistas de receptores benzodiazepínicos, agonistas melatoninérgicos e antagonistas dos receptores serotonérgicos do tipo 2C têm demonstrado eficácia na regularização das alterações do sono em pacientes com depressão. Intervenções não farmacológicas como a terapia cognitivo-comportamental e a fototerapia também são úteis, particularmente quando associadas à medicação antidepressiva.Associação Brasileira de Psiquiatria2014-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-ReviewedRevisado por ParesAvaliado Pelos Paresapplication/pdfhttps://revistardp.org.br/revista/article/view/24010.25118/2763-9037.2014.v4.240Debates in Psychiatry; Vol. 4 No. 3 (2014); 6 -11Debates em Psiquiatria; Vol. 4 Núm. 3 (2014); 6 -11Debates em Psiquiatria; v. 4 n. 3 (2014); 6 -112763-90372236-918Xreponame:Debates em Psiquiatria (Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABPporhttps://revistardp.org.br/revista/article/view/240/216Copyright (c) 2014 Dirceu Zorzetto Filhohttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessFilho, Dirceu Zorzetto2022-06-03T01:21:59Zoai:ojs.emnuvens.com.br:article/240Revistahttps://revistardp.org.br/revista/oaiPUBhttps://revistardp.org.br/revista/oairdp@abp.org.br2763-90372236-918Xopendoar:2022-06-03T01:21:59Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Sleep and circadian rhytms in treatment-resistant depression
Sono e ritmos circadianos na depressão resistente
title Sleep and circadian rhytms in treatment-resistant depression
spellingShingle Sleep and circadian rhytms in treatment-resistant depression
Sleep and circadian rhytms in treatment-resistant depression
Filho, Dirceu Zorzetto
Depressão
Depressão resistente
Tratamento dos transtornos do sono
Depression
Treatment resistant depression
Treatment of sleep disorders
Filho, Dirceu Zorzetto
Depressão
Depressão resistente
Tratamento dos transtornos do sono
Depression
Treatment resistant depression
Treatment of sleep disorders
title_short Sleep and circadian rhytms in treatment-resistant depression
title_full Sleep and circadian rhytms in treatment-resistant depression
title_fullStr Sleep and circadian rhytms in treatment-resistant depression
Sleep and circadian rhytms in treatment-resistant depression
title_full_unstemmed Sleep and circadian rhytms in treatment-resistant depression
Sleep and circadian rhytms in treatment-resistant depression
title_sort Sleep and circadian rhytms in treatment-resistant depression
author Filho, Dirceu Zorzetto
author_facet Filho, Dirceu Zorzetto
Filho, Dirceu Zorzetto
author_role author
dc.contributor.author.fl_str_mv Filho, Dirceu Zorzetto
dc.subject.por.fl_str_mv Depressão
Depressão resistente
Tratamento dos transtornos do sono
Depression
Treatment resistant depression
Treatment of sleep disorders
topic Depressão
Depressão resistente
Tratamento dos transtornos do sono
Depression
Treatment resistant depression
Treatment of sleep disorders
description Sleep and circadian rhythm disturbances are key features of depression. Changes in sleep-wake cycle are often prodromal symptoms of depressive disorders and play a role in the pathophysiology of mood disorders. They predict the onset of a new episode, increase the risk of relapse and recurrence and can also be correlated with a growth in the risk of suicide. Persistent sleep disorders can increase refractoriness to treatment. Patients with treatment resistantdepression have an important circadian deregulation and decreased delta rhythm amplitude during sleep. The available treatments for sleep disorders include hypnotic medications and non-pharmacological interventions. Drugs such as benzodiazepine receptor agonists, melatonin agonists and serotonin type 2C receptors antagonists have been shown to be effective in the treatment of sleep problems in depressive patients. Nonpharmacological interventions such as cognitive-behavioral therapy and phototherapy are also useful, particularly when associated with antidepressant medication.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed
Revisado por Pares
Avaliado Pelos Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistardp.org.br/revista/article/view/240
10.25118/2763-9037.2014.v4.240
url https://revistardp.org.br/revista/article/view/240
identifier_str_mv 10.25118/2763-9037.2014.v4.240
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistardp.org.br/revista/article/view/240/216
dc.rights.driver.fl_str_mv Copyright (c) 2014 Dirceu Zorzetto Filho
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2014 Dirceu Zorzetto Filho
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Debates in Psychiatry; Vol. 4 No. 3 (2014); 6 -11
Debates em Psiquiatria; Vol. 4 Núm. 3 (2014); 6 -11
Debates em Psiquiatria; v. 4 n. 3 (2014); 6 -11
2763-9037
2236-918X
reponame:Debates em Psiquiatria (Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Debates em Psiquiatria (Online)
collection Debates em Psiquiatria (Online)
repository.name.fl_str_mv Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv rdp@abp.org.br
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dc.identifier.doi.none.fl_str_mv 10.25118/2763-9037.2014.v4.240