Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changes

Detalhes bibliográficos
Autor(a) principal: Santos, Suyan Gehlm Ribeiro dos
Data de Publicação: 2014
Outros Autores: Streit, Carla
Tipo de documento: Artigo
Idioma: por
Título da fonte: Debates em Psiquiatria (Online)
Texto Completo: https://revistardp.org.br/revista/article/view/193
Resumo: The Bipolar Disorder (BD) is a chronic psychiatric disease characterized by mood oscillations or mood cyclic changes. It is classified as Type I (one or more manic episodes), the most severe kind of the disease, and Type II (one or more hypomanic episodes). Its causes clinical variations between individuals, and the contributions may come from environmental, biological and genetic factors, epidemiologic varies among 1% to 2% of general population. The purpose of the present study was to perform a literature review on electronic data base approaching bipolar disorder with the role of Brain Derived Neurotrophic Factor (BDNF) and molecular changes. Due to the high rate of patients affected and the various hypotheses studied by researchers to elucidate the mechanisms involved in the disease, this study is necessary in order to contribute to the understanding of it. It was conclude that, even though there are many studies relating polymorphisms to predisposition do bipolar disorder, the physiopathology of the disease was not elucidated completely yet, and additional researches are needed in order to help understanding its progression.
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spelling Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changesRelação do transtorno de humor bipolar com o fator neurotrófico derivado do cérebro (BDNF) e alterações molecularesTranstorno de Humor BipolarFator Neurotrófico Derivado do Cérebro (BDNF)Alterações GenéticasPolimorfismosBipolar DisorderBrain Derived Neurotrophic Factor (BDNF)Genetic ChangesPolymorphismsThe Bipolar Disorder (BD) is a chronic psychiatric disease characterized by mood oscillations or mood cyclic changes. It is classified as Type I (one or more manic episodes), the most severe kind of the disease, and Type II (one or more hypomanic episodes). Its causes clinical variations between individuals, and the contributions may come from environmental, biological and genetic factors, epidemiologic varies among 1% to 2% of general population. The purpose of the present study was to perform a literature review on electronic data base approaching bipolar disorder with the role of Brain Derived Neurotrophic Factor (BDNF) and molecular changes. Due to the high rate of patients affected and the various hypotheses studied by researchers to elucidate the mechanisms involved in the disease, this study is necessary in order to contribute to the understanding of it. It was conclude that, even though there are many studies relating polymorphisms to predisposition do bipolar disorder, the physiopathology of the disease was not elucidated completely yet, and additional researches are needed in order to help understanding its progression.O Transtorno de Humor Bipolar (THB) é uma doença psiquiátrica crônica caracterizada por oscilações ou mudanças cíclicas de humor. Classificado em Tipo I (predomínio de episódios maníacos) forma mais severa da doença e o Tipo II (predomínio de episódios hipomaníacos). Possui origem multifatorial, incluindo influências ambientais, biológicas e genéticas acometendo cerca de 1% a 2 % da população geral. O objetivo deste estudo foi realizar uma revisão da literatura nas bases de dados eletrônicos abordando o transtorno de humor bipolar com o papel do Fator Neurotrófico Derivado do Cérebro (BDNF) e alterações moleculares. Devido ao elevado índice de pacientes acometidos e as diversas hipóteses estudadas por pesquisadores para elucidar os mecanismos envolvidos na doença, este estudo faz-se necessário a fim de contribuir na compreensão da mesma. Conclui-se, que embora haja diversos estudos relacionando polimorfismos à predisposição do THB a fisiopatologia da doença ainda não foi elucidada completamente, necessitando de pesquisas adicionais com o intuito de auxiliar na compreensão e progressão da mesma.Associação Brasileira de Psiquiatria2014-04-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-ReviewedRevisado por ParesAvaliado Pelos Paresapplication/pdfhttps://revistardp.org.br/revista/article/view/19310.25118/2236-918X-4-2-2Debates in Psychiatry; Vol. 4 No. 2 (2014); 16-23Debates em Psiquiatria; Vol. 4 Núm. 2 (2014); 16-23Debates em Psiquiatria; v. 4 n. 2 (2014); 16-232763-90372236-918Xreponame:Debates em Psiquiatria (Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABPporhttps://revistardp.org.br/revista/article/view/193/170https://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessSantos, Suyan Gehlm Ribeiro dosStreit, Carla2023-06-07T23:33:30Zoai:ojs.emnuvens.com.br:article/193Revistahttps://revistardp.org.br/revista/oaiPUBhttps://revistardp.org.br/revista/oairdp@abp.org.br2763-90372236-918Xopendoar:2023-06-07T23:33:30Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changes
Relação do transtorno de humor bipolar com o fator neurotrófico derivado do cérebro (BDNF) e alterações moleculares
title Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changes
spellingShingle Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changes
Santos, Suyan Gehlm Ribeiro dos
Transtorno de Humor Bipolar
Fator Neurotrófico Derivado do Cérebro (BDNF)
Alterações Genéticas
Polimorfismos
Bipolar Disorder
Brain Derived Neurotrophic Factor (BDNF)
Genetic Changes
Polymorphisms
title_short Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changes
title_full Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changes
title_fullStr Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changes
title_full_unstemmed Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changes
title_sort Relationship of mood disorder bipolar with brain-derived neurotrophic factor (BDNF) and molecular changes
author Santos, Suyan Gehlm Ribeiro dos
author_facet Santos, Suyan Gehlm Ribeiro dos
Streit, Carla
author_role author
author2 Streit, Carla
author2_role author
dc.contributor.author.fl_str_mv Santos, Suyan Gehlm Ribeiro dos
Streit, Carla
dc.subject.por.fl_str_mv Transtorno de Humor Bipolar
Fator Neurotrófico Derivado do Cérebro (BDNF)
Alterações Genéticas
Polimorfismos
Bipolar Disorder
Brain Derived Neurotrophic Factor (BDNF)
Genetic Changes
Polymorphisms
topic Transtorno de Humor Bipolar
Fator Neurotrófico Derivado do Cérebro (BDNF)
Alterações Genéticas
Polimorfismos
Bipolar Disorder
Brain Derived Neurotrophic Factor (BDNF)
Genetic Changes
Polymorphisms
description The Bipolar Disorder (BD) is a chronic psychiatric disease characterized by mood oscillations or mood cyclic changes. It is classified as Type I (one or more manic episodes), the most severe kind of the disease, and Type II (one or more hypomanic episodes). Its causes clinical variations between individuals, and the contributions may come from environmental, biological and genetic factors, epidemiologic varies among 1% to 2% of general population. The purpose of the present study was to perform a literature review on electronic data base approaching bipolar disorder with the role of Brain Derived Neurotrophic Factor (BDNF) and molecular changes. Due to the high rate of patients affected and the various hypotheses studied by researchers to elucidate the mechanisms involved in the disease, this study is necessary in order to contribute to the understanding of it. It was conclude that, even though there are many studies relating polymorphisms to predisposition do bipolar disorder, the physiopathology of the disease was not elucidated completely yet, and additional researches are needed in order to help understanding its progression.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed
Revisado por Pares
Avaliado Pelos Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistardp.org.br/revista/article/view/193
10.25118/2236-918X-4-2-2
url https://revistardp.org.br/revista/article/view/193
identifier_str_mv 10.25118/2236-918X-4-2-2
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistardp.org.br/revista/article/view/193/170
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Debates in Psychiatry; Vol. 4 No. 2 (2014); 16-23
Debates em Psiquiatria; Vol. 4 Núm. 2 (2014); 16-23
Debates em Psiquiatria; v. 4 n. 2 (2014); 16-23
2763-9037
2236-918X
reponame:Debates em Psiquiatria (Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Debates em Psiquiatria (Online)
collection Debates em Psiquiatria (Online)
repository.name.fl_str_mv Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv rdp@abp.org.br
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