Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis

Detalhes bibliográficos
Autor(a) principal: Ferreira, Filipa Fiel
Data de Publicação: 2018
Outros Autores: Ribeiro, Filipa, Rodrigues, Rui S., Sebastião, Ana M, Xapelli, Sara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55355
Resumo: Copyright © 2018 Ferreira, Ribeiro, Rodrigues, Sebastião and Xapelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesisBrain-derived neurotrophic factor (BDNF)Cannabinoid receptorsDentate gyrusPostnatal neurogenesisSubventricular zoneCopyright © 2018 Ferreira, Ribeiro, Rodrigues, Sebastião and Xapelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.The adult mammalian brain can produce new neurons in a process called adult neurogenesis, which occurs mainly in the subventricular zone (SVZ) and in the hippocampal dentate gyrus (DG). Brain-derived neurotrophic factor (BDNF) signaling and cannabinoid type 1 and 2 receptors (CB1R and CB2R) have been shown to independently modulate neurogenesis, but how they may interact is unknown. We now used SVZ and DG neurosphere cultures from early (P1-3) postnatal rats to study the CB1R and CB2R crosstalk with BDNF in modulating neurogenesis. BDNF promoted an increase in SVZ and DG stemness and cell proliferation, an effect blocked by a CB2R selective antagonist. CB2R selective activation promoted an increase in DG multipotency, which was inhibited by the presence of a BDNF scavenger. CB1R activation induced an increase in SVZ and DG cell proliferation, being both effects dependent on BDNF. Furthermore, SVZ and DG neuronal differentiation was facilitated by CB1R and/or CB2R activation and this effect was blocked by sequestering endogenous BDNF. Conversely, BDNF promoted neuronal differentiation, an effect abrogated in SVZ cells by CB1R or CB2R blockade while in DG cells was inhibited by CB2R blockade. We conclude that endogenous BDNF is crucial for the cannabinoid-mediated effects on SVZ and DG neurogenesis. On the other hand, cannabinoid receptor signaling is also determinant for BDNF actions upon neurogenesis. These findings provide support for an interaction between BDNF and endocannabinoid signaling to control neurogenesis at distinct levels, further contributing to highlight novel mechanisms in the emerging field of brain repair.This work was supported by Fundação para a Ciência e Tecnologia (FCT) Portugal (PTDC/DTP-FTO/3346/2014). RR (SFRH/BD/129710/2017) and FR (SFRH/BD/74662/2010) were in receipt of a fellowship from FCT. AS thanks the H2020 Twinning Action from EU (SynaNet 692340). SX is an iFCT researcher (IF/01227/2015). BDNF was kindly given by Regeneron. Funded by LISBOA-01-0145-FEDER-007391, project co-funded by FEDER, through POR Lisboa 2020 – Programa Operacional Regional de Lisboa, PORTUGAL 2020, and Fundação para a Ciência e a Tecnologia.FrontiersRepositório da Universidade de LisboaFerreira, Filipa FielRibeiro, FilipaRodrigues, Rui S.Sebastião, Ana MXapelli, Sara2022-12-06T14:29:07Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55355engFront Cell Neurosci. 2018 Nov 28;12:44110.3389/fncel.2018.004411662-5102info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:18:02Zoai:repositorio.ul.pt:10451/55355Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:18:02Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis
title Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis
spellingShingle Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis
Ferreira, Filipa Fiel
Brain-derived neurotrophic factor (BDNF)
Cannabinoid receptors
Dentate gyrus
Postnatal neurogenesis
Subventricular zone
title_short Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis
title_full Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis
title_fullStr Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis
title_full_unstemmed Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis
title_sort Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis
author Ferreira, Filipa Fiel
author_facet Ferreira, Filipa Fiel
Ribeiro, Filipa
Rodrigues, Rui S.
Sebastião, Ana M
Xapelli, Sara
author_role author
author2 Ribeiro, Filipa
Rodrigues, Rui S.
Sebastião, Ana M
Xapelli, Sara
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ferreira, Filipa Fiel
Ribeiro, Filipa
Rodrigues, Rui S.
Sebastião, Ana M
Xapelli, Sara
dc.subject.por.fl_str_mv Brain-derived neurotrophic factor (BDNF)
Cannabinoid receptors
Dentate gyrus
Postnatal neurogenesis
Subventricular zone
topic Brain-derived neurotrophic factor (BDNF)
Cannabinoid receptors
Dentate gyrus
Postnatal neurogenesis
Subventricular zone
description Copyright © 2018 Ferreira, Ribeiro, Rodrigues, Sebastião and Xapelli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2022-12-06T14:29:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55355
url http://hdl.handle.net/10451/55355
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Cell Neurosci. 2018 Nov 28;12:441
10.3389/fncel.2018.00441
1662-5102
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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